New cocktail of drugs shows promise for tough liver cancer

NCT ID NCT05211323

First seen Nov 01, 2025 · Last updated Apr 24, 2026 · Updated 19 times

Summary

This study tests whether adding two immunotherapy drugs (atezolizumab and bevacizumab) to standard chemotherapy works better than chemotherapy plus just one immunotherapy drug for people with a rare, advanced liver cancer that cannot be surgically removed. About 88 adults with this cancer type will be randomly assigned to one of two treatment groups. The main goal is to see which combination helps patients live longer without their cancer growing.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Alta Bates Summit Medical Center-Herrick Campus

    Berkeley, California, 94704, United States

  • Atrium Medical Center-Middletown Regional Hospital

    Franklin, Ohio, 45005-1066, United States

  • California Pacific Medical Center-Pacific Campus

    San Francisco, California, 94115, United States

  • Carle Cancer Center

    Urbana, Illinois, 61801, United States

  • Carle Physician Group-Effingham

    Effingham, Illinois, 62401, United States

  • Carle Physician Group-Mattoon/Charleston

    Mattoon, Illinois, 61938, United States

  • Carle at The Riverfront

    Danville, Illinois, 61832, United States

  • Iowa Methodist Medical Center

    Des Moines, Iowa, 50309, United States

  • Marshfield Medical Center - Minocqua

    Minocqua, Wisconsin, 54548, United States

  • Marshfield Medical Center-EC Cancer Center

    Eau Claire, Wisconsin, 54701, United States

  • Memorial Hospital of South Bend

    South Bend, Indiana, 46601, United States

  • Memorial Medical Center

    Modesto, California, 95355, United States

  • Mercy Medical Center - Des Moines

    Des Moines, Iowa, 50314, United States

  • Miami Valley Cancer Care and Infusion

    Greenville, Ohio, 45331, United States

  • Miami Valley Hospital

    Dayton, Ohio, 45409, United States

  • Miami Valley Hospital North

    Dayton, Ohio, 45415, United States

  • Miami Valley Hospital South

    Centerville, Ohio, 45459, United States

  • Palo Alto Medical Foundation Health Care

    Palo Alto, California, 94301, United States

  • Palo Alto Medical Foundation-Camino Division

    Mountain View, California, 94040, United States

  • Palo Alto Medical Foundation-Fremont

    Fremont, California, 94538, United States

  • Palo Alto Medical Foundation-Santa Cruz

    Santa Cruz, California, 95065, United States

  • Palo Alto Medical Foundation-Sunnyvale

    Sunnyvale, California, 94086, United States

  • Parkland Memorial Hospital

    Dallas, Texas, 75235, United States

  • Premier Blood and Cancer Center

    Dayton, Ohio, 45409, United States

  • Sutter Auburn Faith Hospital

    Auburn, California, 95602, United States

  • Sutter Medical Center Sacramento

    Sacramento, California, 95816, United States

  • Sutter Roseville Medical Center

    Roseville, California, 95661, United States

  • Sutter Solano Medical Center/Cancer Center

    Vallejo, California, 94589, United States

  • The Carle Foundation Hospital

    Urbana, Illinois, 61801, United States

  • UI Health Care Mission Cancer and Blood - Ankeny Clinic

    Ankeny, Iowa, 50023, United States

  • UI Health Care Mission Cancer and Blood - Des Moines Clinic

    Des Moines, Iowa, 50309, United States

  • UT Southwestern Clinical Center at Richardson/Plano

    Richardson, Texas, 75080, United States

  • UT Southwestern/Simmons Cancer Center-Dallas

    Dallas, Texas, 75390, United States

  • UT Southwestern/Simmons Cancer Center-Fort Worth

    Fort Worth, Texas, 76104, United States

  • Upper Valley Medical Center

    Troy, Ohio, 45373, United States

  • VCU Massey Cancer Center at Stony Point

    Richmond, Virginia, 23235, United States

  • VCU Massey Comprehensive Cancer Center

    Richmond, Virginia, 23298, United States

Conditions

Explore the condition pages connected to this study.