Could a common gut drug help fight colorectal cancer?
NCT ID NCT03796884
First seen Oct 31, 2025 · Last updated May 14, 2026 · Updated 30 times
Summary
This study tests whether linaclotide, a drug that helps the intestines release water and salt, can slow or prevent colorectal cancer. About 230 people with colorectal adenomas (precancerous growths) or early-stage colorectal cancer will take the drug or a placebo before surgery. Researchers will measure changes in cell signals and tumor growth to see if the drug has a protective effect.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111, United States
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Sidney Kimmel Cancer Center at Thomas Jefferson University
Philadelphia, Pennsylvania, 19126, United States
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VA Puget Sound Health Care Sysem
Seattle, Washington, 98108, United States
Conditions
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