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Could a simple injection combo replace the dreaded dental nerve block?

NCT ID NCT07771452

Symptom relief Sponsor: Herat University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 18, 2026 · Last updated Aug 20, 2026 · Updated 2 times

Summary

This pilot study tests whether a combination of lidocaine injections—given just under the gum and around the tooth—can fully numb lower molars for dental procedures like fillings, root canals, or extractions, without needing the standard inferior alveolar nerve block. About 60 people aged 16 to 60 who need dental work on lower molars will receive this injection technique. The main question is whether it provides enough pain relief to complete the procedure comfortably, and whether it can be repeated if needed.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
2% lidocaine with epinephrine, given as a combination of supraperiosteal, subperiosteal, and periodontal ligament injections
What this could lead to
If effective, this technique could offer a less invasive alternative to the standard inferior alveolar nerve block for numbing lower molars, potentially reducing discomfort and complications.
What could go wrong
This is a small pilot study, so results may not apply broadly. The technique may not reliably numb the tooth, and there is a risk of needing additional anesthesia or experiencing side effects from lidocaine and epinephrine.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Mar 2025

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 16-60 years. * Patients requiring dental treatment involving mandibular molars. * Patients requiring local anesthesia for the planned dental procedure. * Patients able and willing to provide informed consent. * For participants younger than 18 years, informed consent was obtained from a - parent or legal guardian. Exclusion Criteria: * Known allergy or hypersensitivity to lidocaine or epinephrine. * Medical conditions contraindicating the use of lidocaine with epinephrine. * Presence of acute infection or significant swelling at the injection site. * Patients unable to cooperate with the dental procedure or assessment of anesthetic effectiveness. * Patients who declined to participate or provide informed consent.

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Conditions

The condition(s) this trial relates to.

Pain, Procedural

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Local anesthesia for mandibular molar dental procedure Procedural pain

Contacts and locations

Locations

  • Erfan specialized dental center

    Herat, Herāt, 3002, Afghanistan

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