Can a monthly shot tame Sky-High cholesterol in children?
NCT ID NCT07102511
First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time
Summary
This trial tests whether a monthly injection of lerodalcibep can safely lower LDL cholesterol in children aged 6 to 17 with heterozygous familial hypercholesterolemia, an inherited condition that causes dangerously high cholesterol. Participants receive either the drug or a placebo injection every month for about six months, alongside their usual diet and cholesterol-lowering medications. The study measures changes in LDL levels at 12 and 24 weeks to see if the drug offers additional benefit.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- an experimental drug called lerodalcibep (Lerochol), given as a monthly injection
- What this could lead to
- If it works, this could offer a new monthly injection option to help children with inherited high cholesterol lower their LDL levels.
- What could go wrong
- This is a phase 3 trial, so earlier results are promising but not definitive. The drug may cause side effects or not work as well in younger patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for FAMILIAL HYPERCHOLESTEROLEMIA - HETEROZYGOUS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Ege Universitesi Tip Fakultesi
Izmir, 35100, Turkey (Türkiye)
-
Iatros International
Bloemfontein, Free State, South Africa
-
Lipid Clinic Hadassah Medical Center
Jerusalem, Israel
-
Lipid Clinic Wits University
Johannesburg, Gauteng, 2193, South Africa
-
Metabolic & Atherosclerosis Research Center
Cincinnati, Ohio, 45227, United States
-
New Zealand Clinical Research
Christchurch, 8011, New Zealand
-
The Lipid Clinic Oslo University Hospital
Oslo, 0586, Norway
More trials for these conditions
Other studies related to the condition(s) this trial covers.