New ointment shows promise for stubborn hand eczema
NCT ID NCT02664805
First seen May 07, 2026 · Last updated Jun 22, 2026 · Updated 8 times
Summary
This phase 2a trial tested whether a new ointment called LEO 124249 can improve chronic hand eczema when applied twice daily for up to 8 weeks. 91 adults with hand eczema that didn't respond well to steroid creams took part. The study compared the active ointment to an inactive vehicle to see if it reduces redness, scaling, and itching.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Allergie-Centrum-Charité Klinik für Dermatologie, Venerologie und Allergologie
Berlin, 10117, Germany
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
LEO 124249 ointment
What this could lead to
If it works, this could point toward a new topical treatment option for chronic hand eczema that is not adequately controlled by steroids.
What could go wrong
This is an early proof-of-concept trial with only 91 participants, so results may not apply to everyone. The ointment may not prove more effective than the vehicle (inactive base).
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.