Major Alzheimer's drug trial aims to slow memory loss

NCT ID NCT03887455

Ongoing Disease control Sponsor: Eisai Inc. Source: ClinicalTrials.gov ↗

Summary

This large, late-stage study is testing whether the drug lecanemab can slow the progression of early Alzheimer's disease. Nearly 2,000 participants with mild memory problems will receive either the drug or a placebo for 18 months, followed by an optional long-term extension phase. The main goal is to see if the drug helps people maintain their daily function and thinking skills better than a placebo.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Locations

ANI Neurology, PLLC d/b/a Alzheimer's Memory Center

Charlotte, North Carolina, 28270, United States
ASST-Monza, Ospedale San Gerardo

Monza, 20900, Italy
ActivMed Practices & Research

Methuen, Massachusetts, 01844, United States
Advanced Clinical Research Network

Coral Gables, Florida, 33134, United States
Advanced Memory Research Institute of NJ, PC

Toms River, New Jersey, 08755, United States
Advanced Research Consultants, Inc.

Palm Beach Gardens, Florida, 33410, United States
Advocate Lutheran General Hospital

Park Ridge, Illinois, 60068, United States
Albany Medical College

Albany, New York, 12208, United States
Alliance for Multispecialty Research LLC, New Orleans Center for Clinical Research / Volunteer Research Group, an AMR company

Knoxville, Tennessee, 37920, United States
Allied Biomedical Research (Clinical Trial)

Miami, Florida, 33155, United States
Alzheimer's Research and Treatment Center

Lake Worth, Florida, 33449, United States
Alzheimer's Research and Treatment Center

Stuart, Florida, 34997, United States
Apex Research Institute

Santa Ana, California, 92705, United States
Asan Medical Center

Seoul, 05505, South Korea
Associated Neurologists of Southern Connecticut

Fairfield, Connecticut, 06824, United States
Austin Health - Medical and Cognitive Research Unit

Ivanhoe, Victoria, 3081, Australia
Australian Alzheimer's Research Foundation

Nedlands, Western Australia, 6009, Australia
Azienda Ospedaliero Universitaria Pisana

Pisa, 56126, Italy
Banner Alzheimer's Institute- Clinical Trials Department

Phoenix, Arizona, 85006, United States
Banner Sun Health Research

Sun City, Arizona, 85351, United States
Baotou Central Hospital

Baotou, Inner Mongolia, 014040, China
Baylor College of Medicine AD and Memory Disorders Center

Houston, Texas, 77030, United States
Beijing Friendship Hospital, Capital Medical University

Beijing, Beijing Municipality, 100050, China
Beijing Tiantan Hospital, Capital Medical University

Beijing, Beijing Municipality, 100070, China
Bio Behavioral Health

Toms River, New Jersey, 08755, United States
BioMed Research Institute

Miami, Florida, 33126, United States
Bioclinica Research

Orlando, Florida, 32806, United States
Bioclinica Research

The Villages, Florida, 32162, United States
Boston Center for Memory

Newton, Massachusetts, 02459, United States
Bradenton Research Center, Inc.

Bradenton, Florida, 34205, United States
Brain Matters Research

Delray Beach, Florida, 33445, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
Butler Hospital - Memory and Aging Program

Providence, Rhode Island, 02906, United States
CCM Clinical Research Group

Miami, Florida, 33133, United States
Central Adelaide Local Health Network, The Queen Elizabeth Hospital and the Royal Adelaide Hospital

Woodville South, Adelaid, South Australia, 5011, Australia
Centre de Recherche Clinique du Gérontopôle

Toulouse, Haute Garonne, 31059, France
Centro CAE Oroitu

Getxo, Bizkaia, 48993, Spain
Charing Cross Hospital

London, W6 8RF, United Kingdom
Charter Research

Lady Lake, Florida, 32159, United States
Chonnam National University Hospital

Gwangju, Jeolla-do, 61469, South Korea
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Cleveland Clinic Lou Ruvo Center for Brain Health

Las Vegas, Nevada, 89106, United States
Clincloud, LLC

Maitland, Florida, 32751, United States
Clinica Neurologica, IRCCS Ospedale Policlinico San Martino, Genova

Genova, 16132, Italy
Clinical Trial Network

Houston, Texas, 77074, United States
Coastal Neurology, P.A.

Port Royal, South Carolina, 29935, United States
Columbs Neuroscience, LLC

Columbus, Ohio, 43020, United States
Columbus Memory Center

Columbus, Georgia, 31909, United States
Complejo Hospitalario Ruber Juan Bravo

Madrid, 28006, Spain
DBA The Memory Clinic

Bennington, Vermont, 05201, United States
Donald S. Marks, MD. P.C.

Plymouth, Massachusetts, 02360, United States
Dong-A University Hospital

Busan, 49201, South Korea
Eisai Trial Site #1

Bielefeld, 33647, Germany
Eisai Trial Site #1

Fujioka-shi, Gunma, 3750017, Japan
Eisai Trial Site #10

Shinjuku-ku, Tokyo, 160-8582, Japan
Eisai Trial Site #11

Osaka, 5458586, Japan
Eisai Trial Site #12

Musashino-shi, Tokyo, 180-8610, Japan
Eisai Trial Site #13

Hachioji-shi, Tokyo, 193-0998, Japan
Eisai Trial Site #14

Ube-shi, Yamaguchi, 755-8505, Japan
Eisai Trial Site #15

Chiba, Chiba, 260-8656, Japan
Eisai Trial Site #16

Kurashiki-shi, Okayama-ken, 7100813, Japan
Eisai Trial Site #17

Fujisawa-shi, Kanagawa, 2510038, Japan
Eisai Trial Site #18

Saitama-shi, Saitama, 338-8577, Japan
Eisai Trial Site #19

Kobe, Hyōgo, 6500017, Japan
Eisai Trial Site #2

Mannheim, Baden-Wurttemberg, D-68159, Germany
Eisai Trial Site #2

Yokohama, Kanagawa, 2350012, Japan
Eisai Trial Site #20

Kawasaki-shi, Kanagawa, 2118533, Japan
Eisai Trial Site #21

Hōfu, Yamaguchi, 7470802, Japan
Eisai Trial Site #22

Niigata, Niigata, 9500983, Japan
Eisai Trial Site #23

Shinagawa-ku, Tokyo, 142-0054, Japan
Eisai Trial Site #24

Toride-shi, Ibaraki, 302-0004, Japan
Eisai Trial Site #25

Shinjuku-ku, Tokyo, 160-0023, Japan
Eisai Trial Site #26

Suita-shi, Osaka, 565-0871, Japan
Eisai Trial Site #27

Osaka, 5560017, Japan
Eisai Trial Site #28

Himeji-shi, Hyōgo, 6700981, Japan
Eisai Trial Site #29

Bunkyo-ku, Tokyo, 180-8610, Japan
Eisai Trial Site #3

München, 81675, Germany
Eisai Trial Site #3

Yamagata, Yamagata, 9900834, Japan
Eisai Trial Site #30

Sapporo, Hokkaido, 650033, Japan
Eisai Trial Site #31

Ōtsu, Shiga, 520-2192, Japan
Eisai Trial Site #32

Ōtake, Hiroshima, 7390696, Japan
Eisai Trial Site #33

Higashimorokatagun, Miyazaki, 880-1111, Japan
Eisai Trial Site #4

Erbach im Odenwald, 64711, Germany
Eisai Trial Site #4

Obu-shi, Aichi-ken, 4748511, Japan
Eisai Trial Site #5

Günzburg, Baden-Wurttemberg, 89312, Germany
Eisai Trial Site #5

Bunkyo-ku, Tokyo, 113-0034, Japan
Eisai Trial Site #6

Berlin, 12203, Germany
Eisai Trial Site #6

Yoshida-gun, Fukui, 9101193, Japan
Eisai Trial Site #7

Atsugi-shi, Kanagawa, 2438551, Japan
Eisai Trial Site #8

Hirakata, Osaka, 5731121, Japan
Eisai Trial Site #9

Kahoku, Ishikawa-ken, 920-0293, Japan
Emory University Cognitive Neurology Clinic & ADRC

Atlanta, Georgia, 30329, United States
Finlay Medical Research

Miami, Florida, 33126, United States
First Moscow State Medical University n.a. I.M. Sechenov

Moscow, 119991, Russia
Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico - U.O.S.D. Malattie Neurodegenerative

Milan, 20122, Italy
Fondazione Istituto G.Giglio di Cefalù

Cefalù, Palermo, 90015, Italy
Fondazione Policlinico Agostino Gemelli - UCSC

Roma, 00168, Italy
Fort Wayne Neurological Center

Fort Wayne, Indiana, 46804, United States
Fundacion ACE, Barcelona

Barcelona, 08028, Spain
Fundación CITA-alzheimer Findazioa

Donostia / San Sebastian, Gipuzkoa, 20009, Spain
Galiz Research

Miami Springs, Florida, 33016, United States
Georgetown University Hospital

Washington D.C., District of Columbia, 20057, United States
Gonzalez MD & Aswad MD Health Services

Miami, Florida, 33125, United States
Great Lakes Clinical Trials

Chicago, Illinois, 60640, United States
Groupe Hospitalier Pitie-Salpetriere

Paris, Cedex, 75013, France
Guangdong Provincial People's Hospital

Guangzhou, Guangzhou, 510080, China
Guangzhou First People's Hospital

Guangzhou, Guangdong, 510180, China
Guangzhou Huiai Hospital

Guangzhou, Guangdong, 510450, China
HammondCare Malvern Clinical Trials Unit

Malvern, Victoria, 3144, Australia
Hanyang University Seoul Hospital

Seoul, 04763, South Korea
Hattiesburg Clinic

Hattiesburg, Mississippi, 39401, United States
Hawaii Pacific Neuroscience

Honolulu, Hawaii, 96817, United States
Health Research

West Vancouver, British Columbia, V7T 1C5, Canada
Henan Provincial People's Hospital

Zhengzhou, Henan, 450003, China
Hopital Guillaume et RenÃ LaÃnnec

Nantes, Cedex, 44093, France
Hopital de la Timone

Marseille, Cedex 05, 13385, France
Hospital Clinic i Provincial de Barcelona

Barcelona, 08036, Spain
Hospital General de Catalunya

Sant Cugat del Vallès, Barcelona, 08195, Spain
Hospital Santa Cruz y San Pablo

Barcelona, 8025, Spain
Hospital Universitari i Politècnic La Fe

Valencia, 46026, Spain
Hospital Universitario Reina Sofía

Córdoba, 14011, Spain
Hospital Victoria Eugenia - Cruz Roja

Seville, 41009, Spain
Hospital de Salamanca

Salamanca, 37005, Spain
Hôpital Gui de Chauliac

Montpellier, Cedex 5, 34295, France
Hôpital Lariboisière

Paris, Paris, 75010, France
Hôpital de Hautepierre

Strasbourg, Bas Rhin, 67200, France
Hôpital neurologique Pierre Wertheimer

Bron, 69500, France
IMIC, Inc.

Palmetto Bay, Florida, 33157, United States
ImmunoE Research Center

Centennial, Colorado, 80112, United States
Indiana University School of Medicine

Indianapolis, Indiana, 46202, United States
Infinity Clinical Research

Hollywood, Florida, 33024, United States
Infinity Clinical Research, LLC

Sunrise, Florida, 33351, United States
Inha University Hospital

Incheon, 22332, South Korea
Institute for Neurodegenerative Disorders

New Haven, Connecticut, 06510, United States
Irvine Clinical Research

Irvine, California, 92614, United States
JEM Research Institute

Atlantis, Florida, 33462, United States
Jinan Central Hospital

Jinan, Shandong, 250013, China
KU Wichita Center for Clinical Research

Wichita, Kansas, 67214, United States
KaRa Institute of Neurological Diseases

Macquarie Park, New South Wales, 2229, Australia
Karolinska University Hospital

Stockholm, 141 86, Sweden
Kawartha Centre - Redefining Healthy Aging

Peterborough, Ontario, K9H 2P4, Canada
Kerwin Research Center

Dallas, Texas, 75231, United States
Keystone Clinical Studies, LLC

Norristown, Pennsylvania, 19403, United States
Kingfisher Cooperative LLC

Spokane, Washington, 99202, United States
Konkuk University Medical Center

Seoul, 05030, South Korea
Las Vegas Medical Research

Las Vegas, Nevada, 89113, United States
Linfritz Research Institute, Inc.

Coral Gables, Florida, 33134, United States
Lynn Health Science Institute

Oklahoma City, Oklahoma, 73112, United States
Memory Assessment & Research Centre (MARC),

Southampton, Hampshire, SO30 3JB, United Kingdom
Memory Clinic, Malmö University Hospital

Malmo, 20502, Sweden
Miami Jewish Health Systems

Miami, Florida, 33137, United States
Mile High Research Center

Denver, Colorado, 80218, United States
MoCA Clinic and Institute/NeuroSearch Developpements Inc.

Greenfield Park, Quebec, J4V 2J2, Canada
Nanjing Brain Hospital, Affiliated to Nanjing Medical University

Nanjing, Jiangsu, 210029, China
Nanjing Drum Tower Hospital

Nanjing, Jiangsu, 210008, China
National Clinical Research Inc.-Richmond

Richmond, Virginia, 23294, United States
National University Hospital

Singapore, 119228, Singapore
Neural Net Research, LLC

Portland, Oregon, 97225, United States
NeuroStudies.net, LLC

Decatur, Georgia, 30033, United States
Neurological Associates of Albany, PC

Albany, New York, 12208, United States
Neurological Associates of Tucson dba Center for Neurosciences

Tucson, Arizona, 85718, United States
Neurological Institute of New York

New York, New York, 10032, United States
Neurology Associates of Ormond Beach

Ormond Beach, Florida, 32174, United States
Neurology Center of North Orange County

Fullerton, California, 92835, United States
Neurology Clinic, P.C.

Cordova, Tennessee, 38018, United States
Neuropsychiatric Research Center of Southwest FL

Fort Myers, Florida, 33912, United States
Neurostudies, Inc.

Port Charlotte, Florida, 33952, United States
New York University Medical Center PRIME

New York, New York, 10016, United States
North Bay Neuroscience Research Institute

Sebastopol, California, 95472, United States
OH Clinical Research Partners

Canton, Ohio, 44718, United States
Ohio State University

Columbus, Ohio, 43221, United States
Okanagan Clinical Trials

Kelowna, British Columbia, V1Y 1Z9, Canada
Oregon Health & Science University

Portland, Oregon, 97239, United States
Ospedale "Card. G. Panico" -

Tricase, LE, 73039, Italy
Ospedale S. Maria della Misericordia, S. Andrea delle Fratte

Perugia, 06132, Italy
PMG Research of Winston Salem

Winston-Salem, North Carolina, 27103, United States
Pacific Neuroscience Medical Group

Oxnard, California, 93030, United States
Pacific Research Network, Inc

San Diego, California, 92103, United States
Partners Population Health

Belmont, Massachusetts, 02478, United States
Pharmax Research of South Florida, Inc

Miami, Florida, 33175, United States
Policlinica Guipuzcoa

Donostia / San Sebastian, Guipuzcoa, 20014, Spain
Premiere Research Institute, West Palm

West Palm Beach, Florida, 33407, United States
Prima Clinica Neurologica, Primo Policlinico AOU "L. Vanvitelli"

Naples, 80138, Italy
Progressive Medical Research

Port Orange, Florida, 32127, United States
Q&T Research Sherbrooke Inc.

Sherbrooke, Quebec, J1J 2G2, Canada
Qinghai Provincial People's Hospital

Xining, Qinghai, 810007, China
Quantum Laboratories Inc.

Pompano Beach, Florida, 33064, United States
Raleigh Neurology Associates, P.A. - Research Department

Raleigh, North Carolina, 27607, United States
Re:Cognition Health

Plymouth, Devon, PL6 8BT, United Kingdom
Re:Cognition Health Ltd

Birmingham, B16 8LT, United Kingdom
Re:Cognition Health Ltd

Guildford, GU2 7YD, United Kingdom
Re:Cognition Health Ltd

London, W1G 9JF, United Kingdom
Recherches Neuro-Hippocampe Inc. d/b/a Clinique de la Mémoire de l'Outaouais

Gatineau, Quebec, J8T 8JI, Canada
Recherches Neuro-Hippocampe, Inc., d/b/a Ottawa Memory Clinic

Ottawa, Ontario, K1Z 1G3, Canada
Renji Hospital Shanghai Jiaotong Universtiy School of Medicine

Shanghai, Shanghai Municipality, 200215, China
Renstar Medical Research

Ocala, Florida, 34470, United States
Research Center for Clinical Studies, Inc.

Norwalk, Connecticut, 06851, United States
Rhode Island Hospital

Providence, Rhode Island, 02903, United States
Rhode Island Mood & Memory Research Institute

East Providence, Rhode Island, 02914, United States
Rios Medical Center, Inc.

Miami, Florida, 33135, United States
Roper St. Francis Healthcare

North Charleston, South Carolina, 29406, United States
Sahlgrenska University Hospital

Gothenburg, Västra Götalandslän, 43141, Sweden
Samsung Medical Center

Seoul, 06351, South Korea
Senior Adult Specialty Research

Austin, Texas, 78757, United States
Seoul National University Boramae Medical Center

Seoul, 07061, South Korea
Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, 13620, South Korea
Seoul National University Bundang Hospital

Seongnam-si, Seoul, 13620, South Korea
Seoul National University Hospital

Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System

Seoul, 03722, South Korea
Shanghai Sixth People's Hospital

Shanghai, Shanghai Municipality, 200233, China
Shanghai Tongji Hospital

Shanghai, Shanghai Municipality, 200065, China
Sharp Mesa Vista Hospital

San Diego, California, 92123, United States
Sheffield Memory Service

Sheffield, South Yorkshire, S5 7JT, United Kingdom
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine

Hangzhou, Zhejiang, 310016, China
St Joseph Heritage Healthcare

Santa Rosa, California, 95403, United States
St Vincent's Hospital - Translational Research Centre

Darlinghurst, New South Wales, 2010, Australia
St. Joseph's HC- Parkwood Institute

London, Ontario, N6C 0A7, Canada
St. Pancras Clinical Research

London, EC2Y 8 EA, United Kingdom
Stanford University Medical Center

Palo Alto, California, 94304, United States
Stedman Clinical Trials, LLC

Tampa, Florida, 33613, United States
Summit Research Network (OR) Inc.

Portland, Oregon, 97210, United States
Sun Yat-Sent Memorial Hospital of Sun Yat-Sen University

Guangzhou, Guangdong, 510120, China
Texas Neurology, PA

Dallas, Texas, 75214, United States
The Catholic University of Korea, Seoul ST. Mary's Hospital

Seoul, 06591, South Korea
The First Bethune Hospital of Jilin University

Changchun, Jilin, 130000, China
The Prince Charles Hospital/Internal Medicine & Dementia Research Unit

Chermside Brisbane, Queensland, 4032, Australia
The Second Hospital of Hebei Medical University

Shijiazhuang, Hebei, 50000, China
Tianjin Huanhu Hospital

Tianjin, Tianjin Municipality, 300350, China
Toronto Memory Program (Neurology Research Inc.)

Toronto, Ontario, M3B 2S7, Canada
True North Clinical Research Halifax, Inc.

Halifax, Nova Scotia, B3S 1M7, Canada
True North Clinical Research Kentville, Inc.

Kentville, Nova Scotia, B4N 4K9, Canada
UCSF Memory and Aging Center

San Francisco, California, 94158, United States
USF Suncoast Gerontology Center

Tampa, Florida, 33613, United States
Universita' Sapienza di Roma - Dipartimento di Neuroscienze Umane

Roma, 00185, Italy
University of California - Los Angeles

Los Angeles, California, 90045, United States
University of Kansas Medical Center Research Institute

Kansas City, Kansas, 66160, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University of Rochester

Rochester, New York, 14620, United States
Uppsala University Hospital, Uppsala

Uppsala, 751 85, Sweden
Visionary Investigators Network

Miami, Florida, 33137, United States
Visionary Investigators Network

Miami, Florida, 33180, United States
Vitae Research Center

Miami, Florida, 33135, United States
Washington University

St Louis, Missouri, 63108, United States
Xiangya Hospital Central South University

Changsha, Hunan, 410008, China
Xuanwu Hospital Capital Medical University

Beijing, Beijing Municipality, 100053, China
Yale University School Of Medicine

New Haven, Connecticut, 06510, United States
iResearch Atlanta, LLC

Decatur, Georgia, 30030, United States

Conditions

Explore the condition pages connected to this study.

EARLY ALZHEIMER'S DISEASE