New shot targets debilitating itch of skin condition

NCT ID NCT03816891

Completed Symptom relief Sponsor: Genentech, Inc. Source: ClinicalTrials.gov ↗

Summary

This study tested whether an injectable drug called vixarelimab (KPL-716) could safely reduce severe itching and improve skin lesions in adults with prurigo nodularis. About 240 participants with moderate to severe symptoms received either the drug or a placebo for 8 to 16 weeks to compare results. The main goal was to see how much the drug could lower participants' daily itch scores and improve their quality of life.

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Contacts and locations

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Locations

A.O.U. Policlinico Vittorio Emanuele

Catania, Sicily, 95123, Italy
ALLCUTIS Research, LLC

Beverly, Massachusetts, 01915, United States
ActivMed Practices & Research, Inc.

Methuen, Massachusetts, 01844, United States
Advanced Clinical Research Institute

Tampa, Florida, 33607, United States
Advanced Medical Research PC

Sandy Springs, Georgia, 30328, United States
Alberta DermaSurgery Centre

Edmonton, Alberta, T6G 1C3, Canada
Alliance Clinical Research of Tampa

Tampa, Florida, 33615, United States
Arizona Research Center

Phoenix, Arizona, 85053, United States
Asan Medical Center

Seoul, 05505, South Korea
Asst Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia

Brescia, 25123, Italy
Austin Institute for Clinical Research, Inc.

Pflugerville, Texas, 78660, United States
Barts Health NHS Trust, Whipps Cross Hospital

Leytonstone, E11 1NR, United Kingdom
Bobby Buka MD, PC

New York, New York, 10012, United States
Broadgreen Hospital

Liverpool, L14 3AB, United Kingdom
Brunswick Dermatology Center

Fredericton, New Brunswick, E3B 1G9, Canada
CCR Czech a.s.

Pardubice, 53 002, Czechia
CHU Nantes - Service de Dermatologie

Nantes, 44093, France
CHU de Liège

Liège, 4000, Belgium
CLINTRIAL s.r.o.

Prague, 10000, Czechia
Center for Dermatology Clinical Research, Inc.

Fremont, California, 94538, United States
Central Alberta Research Clinic (CARe Clinic)

Red Deer, Alberta, T4N6V7, Canada
Chang Gung Memorial Hospital

Taoyuan, 333, Taiwan
Cliniques Universitaires Saint-Luc (UCL St-Luc)

Brussels, 1200, Belgium
Colorado Center for Dermatology, PLLC

Centennial, Colorado, 80111, United States
DS Research

New Albany, Indiana, 47150, United States
DS Research

Louisville, Kentucky, 40241, United States
Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States
DermEffects

London, Ontario, N6H 5L5, Canada
Dermatology Research Associates

Los Angeles, California, 90045, United States
Dermatology Specialists of Spokane

Spokane, Washington, 99202, United States
Drc Angélique Gagné-Henley MD Inc.

Saint-Jérôme, Quebec, J7Z 7E2, Canada
Eberhard-Karls-University

Tübingen, 72076, Germany
Fachklinik Bad Bentheim

Bad Bentheim, Lower Saxony, 48455, Germany
First OC Dermatology

Fountain Valley, California, 92708, United States
George Washington University Medical Faculty Associates

Washington D.C., District of Columbia, 20037, United States
George-August-Universität Göttingen

Göttingen, 37075, Germany
Grażyna Pulka Centrum Medyczne All-Med

Krakow, 30-033, Poland
Grekin Skin Institute

Warren, Michigan, 08088, United States
Hamzavi Dermatology

Fort Gratiot, Michigan, 48059, United States
Hautarztpraxis Dr. Hoffmann

Witten, 58453, Germany
Hôpital Morvan - CHU Brest

Brest, 29609, France
Hôpital Saint André - CHU de Bordeaux

Bordeaux, 33075, France
Integrated Clinical Research

West Palm Beach, Florida, 33406, United States
Investigate MD, LLC

Scottsdale, Arizona, 85255, United States
Kliniczny Szpital Wojewódzki Nr 1 im. Fryderyka Chopina w Rzeszowie, Klinika Dermatologii

Rzeszów, 35-055, Poland
Klinikum Bielefeld Rosenhöhe

Bielefeld, North Rhine-Westphalia, 33647, Germany
Kyclinic Przychodnia Lekarsko-Psychologiczna Matusiak Spółka Partnerska

Wroclaw, 50-367, Poland
Lynderm Research Inc.

Markham, Ontario, L3P 1X2, Canada
Medical University of Graz

Graz, 8036, Austria
Medical University of South Carolina, Department of Dermatology and Dermatological Surgery

Charleston, South Carolina, 29425, United States
Medical University of Vienna

Vienna, 1090, Austria
Michigan Center for Skin Care Research

Clinton Township, Michigan, 48038, United States
National Taiwan University Hospital

Taipei, 10002, Taiwan
Olympian Clinical Research

Largo, Florida, 33770, United States
Olympian Clinical Research

St. Petersburg, Florida, 33709, United States
Olympian Clinical Research

Tampa, Florida, 33614, United States
Paddington Testing Co., Inc.

Philadelphia, Pennsylvania, 19103, United States
Palm Harbor Dermatology

Tampa, Florida, 33609, United States
Premier Specialists Pty Ltd

Kogarah, New South Wales, 2217, Australia
Progressive Clinical Research, PA

San Antonio, Texas, 78213, United States
Riverchase Dermatology

Pembroke Pines, Florida, 33028, United States
Royal Infirmary of Edinburgh at Little France

Edinburgh, EH16 4SA, United Kingdom
Rybear, Inc.

Fort Lauderdale, Florida, 33316, United States
Seoul National University Hospital

Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System

Seoul, 03722, South Korea
SimcoDerm Medical and Surgical Dermatology Center

Barrie, Ontario, L4M 7G1, Canada
Skin Specialists, PC

Omaha, Nebraska, 68144, United States
Somerset Skin Centre

Troy, Michigan, 48084, United States
St. George Dermatology & Skin Cancer Centre

Kogarah, New South Wales, 2217, Australia
Stratica Medical

Edmonton, Alberta, T5K 1X3, Canada
Studienzentrale Entzündliche Hauterkrankungen

Erlangen, 91054, Germany
Taipei Medical University Shuang Ho Hospital, Ministry of Health and Welfare

New Taipei City, 23561, Taiwan
Taipei Veterans General Hospital

Taipei, 11217, Taiwan
The Catholic University of Korea, Incheon St. Mary's Hospital

Incheon, 21431, South Korea
The Royal Melbourne Hospital

Parkville, Victoria, 3050, Australia
University Hospital Dresden

Dresden, 01307, Germany
University Hospital Muenster, Department of Dermatology

Münster, 48149, Germany
University Hospital Southampton NHS Foundation Trust

Southampton, SO16 6YD, United Kingdom
University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States
University of Florida, Department of Dermatology

Gainesville, Florida, 32610, United States
University of Miami Itch Center

Miami, Florida, 33136, United States
University of Rochester Dermatology at College Town

Rochester, New York, 14620, United States
Velocity Clinical Research - North Hollywood

North Hollywood, California, 91606, United States
Veracity Clinical Research

Woolloongabba, Queensland, 4102, Australia
Wallace Medical Group, Inc.

Los Angeles, California, 90056, United States
Wright State Physicians

Fairborn, Ohio, 45324, United States

Conditions

Explore the condition pages connected to this study.

PRURIGO NODULARIS PRURITIS