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New eye drop aims to heal persistent corneal defects

NCT ID NCT05727878

Terminated Disease control Sponsor: Combangio, Inc Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 24, 2026 · Updated 27 times

Summary

This study tested an experimental eye drop called KPI-012 for people with a persistent corneal epithelial defect (PCED), a stubborn wound on the eye's surface that hasn't healed for at least a week. The goal was to see if the drops could safely help the wound heal completely. The study enrolled 103 participants but was terminated early.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Principal Investigator

    Dothan, Alabama, 36301, United States

  • Principal Investigator

    Irvine, California, 92897, United States

  • Principal Investigator

    La Jolla, California, 92037, United States

  • Principal Investigator

    Loma Linda, California, 92354, United States

  • Principal Investigator

    Los Angeles, California, 90013, United States

  • Principal Investigator

    Los Angeles, California, 90095, United States

  • Principal Investigator

    Pasadena, California, 91107, United States

  • Principal Investigator

    Rancho Cordova, California, 95670, United States

  • Principal Investigator

    Aurora, Colorado, 80045, United States

  • Principal Investigator

    Fort Collins, Colorado, 80528, United States

  • Principal Investigator

    Littleton, Colorado, 80120, United States

  • Principal Investigator

    Miami, Florida, 33136, United States

  • Principal Investigator

    Miami, Florida, 33143, United States

  • Principal Investigator

    Orange City, Florida, 32763, United States

  • Principal Investigator

    Atlanta, Georgia, 30339, United States

  • Principal Investigator

    Carmel, Indiana, 46290, United States

  • Principal Investigator

    Indianapolis, Indiana, 46260, United States

  • Principal Investigator

    Louisville, Kentucky, 40206, United States

  • Principal Investigator

    Boston, Massachusetts, 02111, United States

  • Principal Investigator

    Boston, Massachusetts, 02114, United States

  • Principal Investigator

    Chesterfield, Missouri, 63017, United States

  • Principal Investigator

    Kansas City, Missouri, 64111, United States

  • Principal Investigator

    Kansas City, Missouri, 64133, United States

  • Principal Investigator

    St Louis, Missouri, 63131, United States

  • Principal Investigator

    Palisades Park, New Jersey, 07650, United States

  • Principal Investigator

    New York, New York, 10036, United States

  • Principal Investigator

    Rockville Centre, New York, 11570, United States

  • Principal Investigator

    Garner, North Carolina, 27529, United States

  • Principal Investigator

    Powell, Ohio, 43065, United States

  • Principal Investigator

    Philadelphia, Pennsylvania, 19107, United States

  • Principal Investigator

    Pittsburgh, Pennsylvania, 15219, United States

  • Principal Investigator

    Rapid City, South Dakota, 57701, United States

  • Principal Investigator

    Memphis, Tennessee, 38119, United States

  • Principal Investigator

    Nashville, Tennessee, 37215, United States

  • Principal Investigator

    Austin, Texas, 78712, United States

  • Principal Investigator

    Austin, Texas, 78731, United States

  • Principal Investigator

    Houston, Texas, 77030, United States

  • Principal Investigator

    San Antonio, Texas, 78212, United States

  • Principal Investigator

    Norfolk, Virginia, 23502, United States

  • Principal Investigator

    Seattle, Washington, 98119, United States

  • Principal Investigator

    Morgantown, West Virginia, 25606, United States

  • Principal Investigator

    Kenosha, Wisconsin, 53142, United States

  • Principal Investigator

    Caba, Buenos Aires, C1428ARF, Argentina

  • Principal Investigator

    Rosario, Santa Fe Province, S2000, Argentina

  • Principal Investigator

    San Juan, 00921, Puerto Rico

  • Principal investigator

    Durham, North Carolina, 27710, United States

Conditions

Explore the condition pages connected to this study.

PERSISTENT CORNEAL EPITHELIAL DEFECT