New hope for tough leukemia: first human trial of ziftomenib underway
NCT ID NCT04067336
First seen Nov 10, 2025 · Last updated May 15, 2026 · Updated 22 times
Summary
This study tests a new drug called ziftomenib for people with acute myeloid leukemia (AML) that has come back or not responded to treatment. The trial includes about 263 participants and aims to find the safest dose and see if the drug can control the disease. It also looks at how the drug works in people with certain genetic changes.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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AZ Delta - Campus Rumbeke
Roeselare, 8800, Belgium
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Banner MD Anderson Cancer Center
Gilbert, Arizona, 85234, United States
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Centre Hospitalier Lyon Sud
Pierre-Bénite, 69310, France
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Centre Hospitalier Universitaire de Lille
Lille, 59037, France
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Centre Hospitalier Universitaire de Nantes
Nantes, 44093, France
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Duke Cancer Institute
Durham, North Carolina, 27710, United States
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Fred Hutchinson Cancer Research Center
Seattle, Washington, 98109, United States
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Hackensack University Medical Center - John Theurer Cancer Center
Hackensack, New Jersey, 07601, United States
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Harold C. Simmons Comprehensive Cancer Center - UT Southwestern Medical Center
Dallas, Texas, 75390, United States
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Hopital Maisonneuve-Rosemont
Montreal, Quebec, H1T 2M4, Canada
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Hopital Saint Louis
Paris, 75475, France
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Hopital de l'Enfant-Jesus - Centre Integre en Cancerologie du CHU de Quebec - Universite Laval
Québec, Quebec, G1J 1Z4, Canada
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Hospital Universitari Vall d'Hebron
Barcelona, 08035, Spain
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Hospital Universitari i Politecnic La Fe
Valencia, 46026, Spain
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Hospital Universitario Central de Asturias
Oviedo, 33011, Spain
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Hospital Universitario HM Sanchinarro
Madrid, 28050, Spain
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Hospital Universitario Virgen del Rocio
Seville, 41013, Spain
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IRCCS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori"
Meldola, 47014, Italy
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Institut Gustave Roussy
Villejuif, 94800, France
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Institute of Hematology and Medical Oncology "L. and A. Seragnoli"
Bologna, 40138, Italy
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Institution Fondazione Policlinico Tor Vergata
Roma, Italy
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Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
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MD Anderson Cancer Center
Madrid, 28033, Spain
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Magendie Hopital Haut-Leveque
Pessac, 33600, France
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Mayo Clinic
Jacksonville, Florida, 32224, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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Medizinische Hochsschule Hannover
Hanover, 30625, Germany
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Oklahoma University Health - Stephenson Cancer Center
Oklahoma City, Oklahoma, 73117, United States
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Queen Elizabeth II Health Sciences Centre
Halifax, Nova Scotia, B3H 1V7, Canada
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Robert H. Lurie Comprehensive Cancer Center of Northwestern University
Chicago, Illinois, 60611, United States
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Roswell Park Comprehensive Cancer Center
Buffalo, New York, 14203, United States
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The Mount Sinai Hospital
New York, New York, 10029, United States
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UCLA Ronald Reagan Medical Center
Los Angeles, California, 90095, United States
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UO Ematologia Ospedale di Ravenna
Ravenna, 48121, Italy
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UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, 15232, United States
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Universitat de Barcelona
Barcelona, 08035, Spain
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University Medicine Greifswald
Greifswald, 17475, Germany
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University of Maryland Greenebaum Comprehensive Cancer Center
Baltimore, Maryland, 21201, United States
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University of Michigan Hospitals
Ann Arbor, Michigan, 48109, United States
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Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, 37232, United States
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Weill Cornell Medical College - NY Presbyterian Hospital
New York, New York, 10021, United States
Conditions
Explore the condition pages connected to this study.