Knee replacement pain relief showdown: which numbing cocktail wins?
NCT ID NCT07509866
First seen Apr 10, 2026
Summary
This study tests three different numbing medicine combinations for pain after total knee replacement. 90 adults having knee surgery will get one of three options: a long-acting numbing drug, or a standard numbing drug plus one of two additives. The goal is to see which approach reduces the need for opioid painkillers and helps people get moving sooner.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for OSTEOARTHRITIS are added.
By submitting, you agree to our Terms of use
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
RECRUITINGWuhan, Hubei, 430022, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Liposomal bupivacaine, ropivacaine with dexamethasone, ropivacaine with dexmedetomidine
What this could lead to
If successful, this could identify the most effective numbing approach for knee replacement surgery, leading to less pain, less opioid use, and faster recovery.
What could go wrong
This is a small, early-stage trial with only 90 participants, so results may not apply to everyone. The different numbing methods may work similarly, and unexpected side effects are possible.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.