New drug duo aims to outsmart advanced kidney cancer

NCT ID NCT05928806

First seen Jan 03, 2026 · Last updated May 14, 2026 · Updated 22 times

Summary

This study tests whether a new combination of immunotherapy drugs (botensilimab and balstilimab) works better than the current standard treatment for advanced kidney cancer. About 120 people with untreated metastatic clear cell renal cell carcinoma will take part. The goal is to see if the new combo shrinks tumors more effectively and for longer.

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Contacts and locations

Locations

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • Columbia University Irving Medical Center

    New York, New York, 10032, United States

  • Cornell University

    Ithaca, New York, 14850, United States

  • Dana-Farber - Partners Cancer Care, Inc

    Boston, Massachusetts, 02215, United States

  • Georgetown University

    Washington D.C., District of Columbia, 20057, United States

  • Indiana University Melvin and Bren Simon Comprehensive Cancer Center

    Indianapolis, Indiana, 46202, United States

  • John Theurer Cancer Center

    Hackensack, New Jersey, 07601, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

  • Penn Medicine Abramson Cancer Center

    Philadelphia, Pennsylvania, 19104, United States

  • University of California San Diego

    La Jolla, California, 92093, United States

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75390, United States

  • Winship Cancer Institute of Emory University

    Atlanta, Georgia, 30322, United States

  • Yale University, Yale Cancer Center

    New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.