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A shot against the shakes: could a Low-Dose drug stop Post-Surgery shivering?

NCT ID NCT07787702

Symptom relief Sponsor: Shaheed Mohtarma Benazir Bhutto Institue of Trauma Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 26, 2026 · Last updated Aug 27, 2026 · Updated 1 time

Summary

This trial tests whether a small dose of ketamine or tramadol, given right after spinal anesthesia, can prevent the shivering that often follows. It includes adults aged 18 to 60 undergoing orthopedic surgery. The study compares how often and how severely shivering occurs with each drug, aiming to find a better way to keep patients comfortable.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Low-dose intravenous ketamine or tramadol given right after spinal anesthesia to prevent shivering.
What this could lead to
If effective, this could identify a better preventive option for post-anesthesia shivering, improving patient comfort during recovery.
What could go wrong
This is a small, early-stage trial, and results may not apply broadly. Both drugs carry potential side effects, and the optimal dose or benefit may not be confirmed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 106 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * \* ASA I and II patients aged 18-60 years. * Both genders. * Patients undergoing orthopedic surgery under spinal anesthesia. Exclusion Criteria: * \* Patient refusal. * ASA III and ASA IV. * Prolonged surgical procedures expected to be more than 90 minutes. * Patients who received blood transfusion or study drugs other than for the study purpose.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Post-spinal anesthesia shivering

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Shaheed Mohtarma Benazir Bhutto Institute of Trauma (SMBBIT)

    Karachi, Sindh, 74200, Pakistan