New hope for KRAS lung cancer: targeted pill plus immunotherapy vs. chemo in major trial

NCT ID NCT07190248

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 08, 2026 · Updated 20 times

Summary

This study tests whether a new targeted pill (MK-1084) combined with an immunotherapy (pembrolizumab) can help people with a specific KRAS-mutated advanced lung cancer live longer without their cancer growing, compared to standard chemo plus immunotherapy. About 675 adults with non-squamous non-small cell lung cancer that has spread and has the KRAS G12C mutation will take part. The goal is to find a more effective first treatment that may delay disease progression.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

A.O.R.N. Antonio Cardarelli ( Site 1810)
RECRUITING

Naples, 80131, Italy

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AFFILIATED CANCER HOSPITAL AND INSTITUTE OF GUANGZHOU MEDICAL UNIVERSITY ( Site 2743)
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Guangzhou, Guangdong, 510095, China

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AOU Careggi ( Site 1801)
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Florence, Tuscany, 50134, Italy

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AOU Renato Dulbecco ( Site 1804)
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Catanzaro, 88100, Italy

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Affiliated Cancer Hospital of Guangxi Medical University ( Site 2704)
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Nanning, Guangxi, 530021, China

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Agios Andreas Hospital Patras ( Site 1407)
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Pátrai, Achaia, 263 35, Greece

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Amphia Ziekenhuis, locatie Breda Molengracht ( Site 1907)
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Breda, North Brabant, 4818 CK, Netherlands

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Anhui Provincial Cancer Hospital ( Site 2708)
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Hefei, Anhui, 230031, China

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Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento ( Site 1809)
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Verona, 37126, Italy

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Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII ( Site 1811)
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Bergamo, Lombardy, 24127, Italy

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Beijing Cancer hospital-Thoracic Cancer Department A ( Site 2700)
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Beijing, Beijing Municipality, 100142, China

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Beijing Peking Union Medical College Hospital ( Site 2702)
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Beijing, Beijing Municipality, 100730, China

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Blue Ridge Cancer Care ( Site 0144)
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Roanoke, Virginia, 24014, United States

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Bradfordhill ( Site 0501)
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Santiago, Region M. de Santiago, 8420383, Chile

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CEMAIC ( Site 0309)
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Córdoba, X5008AAC, Argentina

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CEPEN - Centro de Pesquisa e Ensino em Oncologia de Santa Catarina ( Site 0410)
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Florianópolis, Santa Catarina, 88020-210, Brazil

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CHU Caen ( Site 1212)
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Caen, Calvados, 14000, France

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CRIO - CENTRO REGIONAL INTEGRADO DE ONCOLOGIA ( Site 0412)
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Fortaleza, Ceará, 60336-232, Brazil

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Central Alabama Research ( Site 0108)
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Birmingham, Alabama, 35209, United States

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Centre Hospitalier Metropole Savoie Site de Chambery ( Site 1208)
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Chambéry, Savoie, 73011, France

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Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois ( Site 1209)
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Vandœuvre-lès-Nancy, Meurthe-et-Moselle, 54500, France

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Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa ( Site 0400)
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Porto Alegre, Rio Grande do Sul, 90110-270, Brazil

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Centro de Estudios Clínicos SAGA ( Site 0503)
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Santiago, Region M. de Santiago, 7500653, Chile

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Centrul de Oncologie "Sfântul Nectarie" ( Site 2107)
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Craiova, Dolj, 200347, Romania

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Chang Gung Memorial Hospital- Chiayi ( Site 3611)
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Chiayi City, Chiayi, 613, Taiwan

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Chiba University Hospital ( Site 2812)
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Chiba, 260-8677, Japan

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Chongqing University Cancer Hospital ( Site 2736)
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Chongqing, Sichuan, 400030, China

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Chonnam National University Hwasun Hospital ( Site 3502)
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Jeollanam-do, Jeonranamdo, 58128, South Korea

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Chungnam National University Hospital ( Site 3503)
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Daejeon, Taejon-Kwangyokshi, 35015, South Korea

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Clinique de l'Europe ( Site 1213)
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Amiens, Somme, 80000, France

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Communal noncommercial enterprise of Lviv regional council "Lviv oncological regional therapeutical ( Site 2507)
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Lviv, Lviv Oblast, 79031, Ukraine

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Complejo Hospitalario Universitario A Coruna ( Site 2207)
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A Coruña, La Coruna, 15006, Spain

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Delta Health Care SRL ( Site 2108)
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Bucharest, 014142, Romania

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Errikos Dunant Hospital Center ( Site 1408)
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Athens, Attica, 115 26, Greece

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Faculdade de Medicina do ABC ( Site 0411)
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Santo André, São Paulo, 09060-870, Brazil

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Fujian Provincial Cancer Hospital ( Site 2706)
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Fuzhou, Fujian, 350014, China

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Fujita Health University Hospital ( Site 2807)
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Toyoake, Aichi-ken, 470-1192, Japan

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General Hospital of Athens "Laiko" ( Site 1402)
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Athens, Attica, 11526, Greece

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Genesis Care- Campbelltown ( Site 2907)
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Campbelltown, New South Wales, 2560, Australia

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Groupe Hospitalier Paris Saint Joseph ( Site 1215)
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Paris, 75014, France

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HOSPITAL CLÍNIC DE BARCELONA ( Site 2201)
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Barcelona, Catalonia, 08036, Spain

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HOSPITAL UNIVERSITARIO PUERTA DE HIERRO MAJADAHONDA ( Site 2202)
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Majadahonda, Madrid, Comunidad de, 28220, Spain

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Henan Cancer Hospital ( Site 2746)
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Zhengzhou, Henan, 450008, China

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Hirosaki University Hospital ( Site 2818)
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Hirosaki, Aomori, 036-8563, Japan

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Hiroshima City Hiroshima Citizens Hospital ( Site 2821)
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Hiroshima, 730-8518, Japan

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Hopital Europeen Marseille ( Site 1207)
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Marseille, Bouches-du-Rhone, 13003, France

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Hospital Alemao Oswaldo Cruz ( Site 0413)
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São Paulo, São Paulo, 01327-001, Brazil

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Hospital General Universitario de Valencia ( Site 2204)
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Valencia, Valenciana, Comunitat, 46014, Spain

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Hospital Italiano de Cordoba ( Site 0308)
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Córdoba, X5004BAL, Argentina

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Hospital Pulau Pinang ( Site 3108)
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George Town, Pulau Pinang, 10990, Malaysia

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Hospital Santa Rita de Cassia ( Site 0403)
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Vitória, Espírito Santo, 29043-260, Brazil

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Hospital Tengku Ampuan Afzan ( Site 3109)
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Kuantan, Pahang, 25100, Malaysia

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Hospital Universitario Ramon y Cajal ( Site 2203)
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Madrid, 28034, Spain

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Hospital Universitario Virgen de Valme ( Site 2205)
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Seville, 41014, Spain

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Hospital Wanita and Kanak Kanak Sabah ( Site 3110)
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Kota Kinabalu, Sabah, 88996, Malaysia

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Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto USP ( Site 0419)
RECRUITING

Ribeirão Preto, São Paulo, 14048-900, Brazil

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Hubei Cancer Hospital ( Site 2721)
RECRUITING

Wuhan, Hubei, 430079, China

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Hôpital Européen Georges Pompidou ( Site 1214)
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Paris, 75015, France

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IBCC - Núcleo de Pesquisa e Ensino ( Site 0417)
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São Paulo, 04014-002, Brazil

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IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" ( Site 1807)
RECRUITING

Meldola, Forli-Cesena, 47014, Italy

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Indiana University Health Arnett Cancer Center ( Site 0116)
RECRUITING

Lafayette, Indiana, 47904, United States

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Institut Català d'Oncologia (ICO) - Badalona ( Site 2200)
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Badalona, Catalonia, 08916, Spain

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Instituto Alexander Fleming ( Site 0311)
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Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426ANZ, Argentina

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Instituto de Investigaciones Clinicas Mar del Plata ( Site 0300)
RECRUITING

Mar del Plata, Buenos Aires, B7600FZO, Argentina

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Institutul Oncologic Prof. Dr. I Chiricuta ( Site 2103)
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Cluj-Napoca, Cluj, 400015, Romania

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Istituto Clinico Humanitas ( Site 1812)
RECRUITING

Rozzano, Milano, 20089, Italy

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JIAMUSI TUBERCULOSIS HOSPITAL(CANCER HOSPITAL) ( Site 2745)
RECRUITING

Jiamusi, Heilongjiang, 154007, China

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Jiangxi Cancer Hospital ( Site 2725)
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Nanchang, Jiangxi, 330029, China

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Kanagawa Cancer Center ( Site 2820)
RECRUITING

Yokohama, Kanagawa, 241-8515, Japan

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Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 1001)
RECRUITING

Vienna, 1210, Austria

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Kobe City Medical Center General Hospital ( Site 2811)
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Kobe, Hyōgo, 650-0047, Japan

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Korea University Guro Hospital ( Site 3505)
RECRUITING

Seoul, 08308, South Korea

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Kyung Hee University Medical Center ( Site 3500)
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Seoul, 02447, South Korea

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Lancaster General Hospital - Ann B Barshinger Cancer Institute ( Site 0111)
RECRUITING

Lancaster, Pennsylvania, 17601, United States

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Leicester Royal Infirmary ( Site 2610)
RECRUITING

Leicester, LE1 5WW, United Kingdom

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LinYi Cancer Hospital ( Site 2737)
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Linyi, Shandong, 276000, China

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ME RIVNE REGIONAL ANTITUMOR CENTER ( Site 2517)
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Rivne, Rivne Oblast, 33010, Ukraine

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MacKay Memorial Hospital ( Site 3609)
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Taipei, 10449, Taiwan

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Mater Hospital Brisbane ( Site 2906)
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South Brisbane, Queensland, 4101, Australia

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Medizinische Universität Graz-Klinische Abteilung für Pulmonologie ( Site 1005)
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Graz, Styria, 8036, Austria

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Meir Medical Center. ( Site 1702)
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Kfar Saba, 4428164, Israel

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Metropolitan General Hospital ( Site 1400)
RECRUITING

Athens, Attica, 155 62, Greece

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Mount Sinai Cancer Center ( Site 0137)
COMPLETED

Miami Beach, Florida, 33140, United States
Municipal Enterprise "Bukovinian сlinical oncology сenter" ( Site 2504)
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Chernivtsi, Chernivetska Oblast, 58013, Ukraine

Contact Phone: •••-•••-••••
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School ( Site 2715)
ACTIVE_NOT_RECRUITING

Nanjing, Jiangsu, 210000, China
Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 2012)
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Gliwice, Silesian Voivodeship, 44-102, Poland

Contact Phone: •••-•••-••••
National Center for Global Health and Medicine ( Site 2806)
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Shinjuku, Tokyo, 162-8655, Japan

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National Cheng Kung University Hospital ( Site 3604)
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Tainan, 704, Taiwan

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National Hospital Organization Himeji Medical Center ( Site 2827)
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Himeji, Hyōgo, 670-8520, Japan

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National Hospital Organization Kinki-chuo Chest Medical Center ( Site 2822)
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Sakai, Osaka, 591-8555, Japan

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National Hospital Organization Kyushu Medical Center ( Site 2801)
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Fukuoka, 810-8563, Japan

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National Hospital Organization Ureshino Medical Center ( Site 2817)
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Ureshino, Saga-ken, 843-0393, Japan

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New England Cancer Specialists ( Site 0139)
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Westbrook, Maine, 04092, United States

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New York Oncology Hematology, P.C. ( Site 0119)
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Albany, New York, 12206, United States

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Nippon Medical School Hospital ( Site 2819)
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Bunkyo, Tokyo, 113-8603, Japan

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Northern Beaches Hospital ( Site 2905)
RECRUITING

Frenchs Forest, New South Wales, 2086, Australia

Contact Phone: •••-•••-••••
Orszagos Koranyi Pulmonologiai Intezet ( Site 1501)
RECRUITING

Budapest, Pest County, 1121, Hungary

Contact Phone: •••-•••-••••
Osaka Medical and Pharmaceutical University Hospital ( Site 2810)
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Takatsuki, Osaka, 569-8686, Japan

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Osaka Metropolitan University Hospital ( Site 2826)
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Osaka, 545-8586, Japan

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Ospedale San Giuseppe Moscati ( Site 1816)
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Statte, Taranto, 74010, Italy

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Papageorgiou General Hospital of Thessaloniki ( Site 1403)
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Thessaloniki, 564 29, Greece

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Policlinico San Matteo ( Site 1802)
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Pavia, 27100, Italy

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Pusan National University Hospital ( Site 3501)
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Busan, Pusan-Kwangyokshi, 49241, South Korea

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Pusan National University Yangsan Hospital ( Site 3504)
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Yangsan, Kyongsangnam-do, 50612, South Korea

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Real Hospital Portugues ( Site 0418)
RECRUITING

Recife, Pernambuco, 52010075, Brazil

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Reformatus Pulmonologiai Centrum ( Site 1503)
RECRUITING

Törökbálint, Pest County, 2045, Hungary

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Royal Cornwall Hospital ( Site 2614)
RECRUITING

Truro, Cornwall, TR1 2LJ, United Kingdom

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Royal Free Hospital ( Site 2601)
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London, London, City of, NW3 2QG, United Kingdom

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SC MNT Healthcare Europe SRL ( Site 2105)
RECRUITING

Bucharest, 013975, Romania

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SC ONCO CARD SRL ( Site 2109)
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Brasov, 500052, Romania

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SC Radiotherapy Center Cluj SRL-Oncologie Medicala ( Site 2101)
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Florești, Cluj, 407280, Romania

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Saiseikai Kumamoto Hospital ( Site 2816)
RECRUITING

Kumamoto, 861-4193, Japan

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Saiseikai Matsusaka Municipal Hospital ( Site 2808)
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Matsusaka, Mie-ken, 515-8544, Japan

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Sarawak General Hospital ( Site 3101)
RECRUITING

Kuching, Sarawak, 93586, Malaysia

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Shaare Zedek Medical Center ( Site 1706)
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Jerusalem, 9103102, Israel

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Shalimov Institute of Surgery and Transplantation Oncology department ( Site 2512)
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Kyiv, 02000, Ukraine

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Shanghai Pulmonary Hospital-Oncology Department ( Site 2723)
RECRUITING

Shanghai, Shanghai Municipality, 200433, China

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Shanxi Cancer Hospital ( Site 2728)
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Taiyuan, Shanxi, 030013, China

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Sheba Medical Center ( Site 1700)
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Ramat Gan, 5265601, Israel

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Sichuan Cancer Hospital. ( Site 2739)
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Chengdu, Sichuan, 610213, China

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Sir Run Run Shaw Hospital ( Site 2731)
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Hangzhou, Zhejiang, 310015, China

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Sourasky Medical Center ( Site 1705)
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Tel Aviv, 6423906, Israel

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Spitalul Clinic Colțea ( Site 2102)
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Bucharest, Bucharest, 030171, Romania

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Spitalul Municipal Schuller Ploiești ( Site 2106)
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Ploieşti, Prahova, 100337, Romania

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Stamford Hospital ( Site 0126)
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Stamford, Connecticut, 06902, United States

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Sunway Medical Centre ( Site 3106)
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Petaling Jaya, Selangor, 47500, Malaysia

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Taipei Medical University Shuang Ho Hospital ( Site 3602)
RECRUITING

New Taipei City, 235, Taiwan

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Taizhou Hospital of Zhejiang Province-Respiratory ( Site 2724)
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Taizhou, Zhejiang, 317000, China

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Takarazuka City Hospital ( Site 2828)
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Takarazuka, Hyōgo, 665-0827, Japan

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The First Affiliated Hospital of Fujian Medical University ( Site 2701)
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Fujian, Fujian, 350005, China

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The First Affiliated Hospital of Xi'an Jiaotong University ( Site 2729)
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Xi'an, Shaanxi, 710061, China

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The First Affiliated Hospital of Xiamen University ( Site 2717)
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Fuzhou, Fujian, 361003, China

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The First Affiliated Hospital.Sun Yat-sen University ( Site 2714)
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Guangzhou, Guangdong, 510080, China

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The Prince Charles Hospital ( Site 2903)
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Brisbane, Queensland, 4032, Australia

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Tohoku University Hospital ( Site 2804)
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Sendai, Miyagi, 980-8574, Japan

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Tokyo Medical University Hospital ( Site 2829)
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Shinjuku, Tokyo, 160-0023, Japan

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Tongji Hospital Tongji Medical,Science & Technology ( Site 2722)
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Wuhan, Hubei, 430030, China

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Tri-Service General Hospital ( Site 3603)
RECRUITING

Taipei, 114, Taiwan

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Universal Clinic Oberig ( Site 2506)
RECRUITING

Kyiv, 03057, Ukraine

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Warminsko-Mazurskie Centrum Chorob Pluc w Olsztynie ( Site 2004)
RECRUITING

Olsztyn, Warmian-Masurian Voivodeship, 10-357, Poland

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West China Hospital Sichuan University ( Site 2735)
RECRUITING

Chengdu, Sichuan, 611135, China

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Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 2008)
RECRUITING

Przemyśl, Podkarpackie Voivodeship, 37-700, Poland

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Xiangya Hospital Central South University ( Site 2741)
RECRUITING

Changsha, Hunan, 410008, China

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Yitzhak Shamir Medical Center. ( Site 1709)
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Beer Ya Akov, 7033001, Israel

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Yokohama Municipal Citizen's Hospital ( Site 2824)
RECRUITING

Yokohama, Kanagawa, 221-0855, Japan

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Yunnan Province Cancer Hospital ( Site 2734)
RECRUITING

Kunming, Yunnan, 650118, China

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Zhejiang Cancer Hospital ( Site 2727)
RECRUITING

Hangzhou, Zhejiang, 310022, China

Contact Phone: •••-•••-••••
Zhujiang Hospital of Southern Medical University ( Site 2744)
RECRUITING

Guangzhou, Guangdong, 510280, China

Contact Phone: •••-•••-••••
Ziekenhuis Oost-Limburg, Campus St.-Jan ( Site 3903)
RECRUITING

Genk, Limburg, 3600, Belgium

Contact Phone: •••-•••-••••

Conditions

Explore the condition pages connected to this study.

NON-SMALL CELL LUNG CANCER