New hope for men with advanced prostate cancer: drug combo trial launches

NCT ID NCT06991556

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 03, 2026 · Updated 25 times

Summary

This study tests whether adding a new drug, JSB462 (luxdegalutamide), to standard hormone therapy (abiraterone) works better than current treatments for men whose prostate cancer has spread and still responds to hormones. About 150 men will receive either the combination or standard care. The goal is to see if the combination lowers PSA levels more effectively and to find the right dose for future studies.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for METASTATIC HORMONE-SENSITIVE PROSTATE CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Advanced Urology Ins Daytona Beach
RECRUITING

Daytona Beach, Florida, 32114, United States

Contact

Contact Email: •••••@•••••
American Oncology Partners PA Center for Cancer and Blood Disorders
RECRUITING

Bethesda, Maryland, 20817, United States

Contact

Contact Email: •••••@•••••
Associated Med Professionals of NY
RECRUITING

Syracuse, New York, 13210, United States

Contact Email: •••••@•••••

Contact
Associated Urological Specialists
RECRUITING

Chicago Ridge, Illinois, 60415, United States

Contact

Contact Email: •••••@•••••
Carolina Urologic Research Center
RECRUITING

Myrtle Beach, South Carolina, 29572, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Emory University School of Medicine-Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Fred Hutch Cancer Research
RECRUITING

Seattle, Washington, 98109, United States

Contact Email: •••••@•••••

Contact
Mass General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States

Contact Email: •••••@•••••

Contact
Michigan Institute of Urology
RECRUITING

West Bloomfield, Michigan, 48322, United States

Contact

Contact Email: •••••@•••••
MidLantic Urology
RECRUITING

Bala-Cynwyd, Pennsylvania, 19004, United States

Contact Email: •••••@•••••

Contact
Novartis Investigative Site
RECRUITING

Adelaide, South Australia, 5000, Australia
Novartis Investigative Site
RECRUITING

Clayton, Victoria, 3168, Australia
Novartis Investigative Site
RECRUITING

São Paulo, São Paulo, 01221-020, Brazil
Novartis Investigative Site
RECRUITING

Vancouver, British Columbia, V5Z 1M9, Canada
Novartis Investigative Site
RECRUITING

Halifax, Nova Scotia, B3H 2Y9, Canada
Novartis Investigative Site
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Novartis Investigative Site
RECRUITING

Beijing, Chaoyang, 100021, China
Novartis Investigative Site
RECRUITING

Beijing, 100034, China
Novartis Investigative Site
RECRUITING

Brno, 656 53, Czechia
Novartis Investigative Site
RECRUITING

Olomouc, 779 00, Czechia
Novartis Investigative Site
RECRUITING

Prague, 150 06, Czechia
Novartis Investigative Site
RECRUITING

Nice, Alpes Maritimes, 06189, France
Novartis Investigative Site
RECRUITING

Marseille, 13273, France
Novartis Investigative Site
RECRUITING

Quint-Fonsegrives, 31130, France
Novartis Investigative Site
RECRUITING

Suresnes, 92150, France
Novartis Investigative Site
RECRUITING

Düsseldorf, North Rhine-Westphalia, 40225, Germany
Novartis Investigative Site
RECRUITING

Hamburg, 20246, Germany
Novartis Investigative Site
RECRUITING

Lübeck, 23538, Germany
Novartis Investigative Site
RECRUITING

Nürtingen, 72622, Germany
Novartis Investigative Site
RECRUITING

Asti, AT, 14100, Italy
Novartis Investigative Site
RECRUITING

Padova, PD, 35128, Italy
Novartis Investigative Site
RECRUITING

Trento, TN, 38122, Italy
Novartis Investigative Site
RECRUITING

Orbassano, TO, 10043, Italy
Novartis Investigative Site
RECRUITING

Verona, VR, 37134, Italy
Novartis Investigative Site
RECRUITING

Zwolle, Overijssel, 8025 AB, Netherlands
Novartis Investigative Site
RECRUITING

Dordrecht, South Holland, 3318 AT, Netherlands
Novartis Investigative Site
RECRUITING

Hoofddorp, 2134 TM, Netherlands
Novartis Investigative Site
RECRUITING

Schiedam, 3118 JH, Netherlands
Novartis Investigative Site
RECRUITING

Kielce, 25-640, Poland
Novartis Investigative Site
RECRUITING

Olsztyn, 10-288, Poland
Novartis Investigative Site
RECRUITING

Oświęcim, 32-600, Poland
Novartis Investigative Site
RECRUITING

Skorzewo, 60-185, Poland
Novartis Investigative Site
RECRUITING

Singapore, 119074, Singapore
Novartis Investigative Site
RECRUITING

Singapore, 169608, Singapore
Novartis Investigative Site
RECRUITING

Singapore, S308433, Singapore
Novartis Investigative Site
RECRUITING

Seoul, 03080, South Korea
Novartis Investigative Site
RECRUITING

Seoul, 06351, South Korea
Novartis Investigative Site
RECRUITING

Santander, Cantabria, 39008, Spain
Novartis Investigative Site
RECRUITING

Badajoz, Extremadura, 06080, Spain
Novartis Investigative Site
RECRUITING

Lugo, Galicia, 27003, Spain
Novartis Investigative Site
RECRUITING

Pamplona, Navarre, 31008, Spain
Novartis Investigative Site
RECRUITING

Barcelona, 08036, Spain
Novartis Investigative Site
RECRUITING

Córdoba, 14004, Spain
Novartis Investigative Site
RECRUITING

Kaohsiung City, 83301, Taiwan
Novartis Investigative Site
RECRUITING

Tainan, 704302, Taiwan
Perlmutter Cancer Centre
RECRUITING

New York, New York, 10016, United States

Contact

Contact Email: •••••@•••••
Rocky Mountain Cancer Centers
RECRUITING

Denver, Colorado, 80218, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Saint Johns Cancer Institute
RECRUITING

Santa Monica, California, 90404, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Tennessee Oncology
RECRUITING

Nashville, Tennessee, 37203, United States

Contact

Contact Email: •••••@•••••
University of California San Diego - Moores Cancer Center
RECRUITING

La Jolla, California, 92093-0658, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Urology San Antonio
RECRUITING

San Antonio, Texas, 78229, United States

Contact

Contact Email: •••••@•••••
Virginia Oncology Associates
RECRUITING

Norfolk, Virginia, 23502, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
XCancer Omaha LLC
RECRUITING

Omaha, Nebraska, 68130, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Yale Cancer Center
RECRUITING

New Haven, Connecticut, 06520, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

METASTATIC HORMONE-SENSITIVE PROSTATE CANCER