Hope for rare amyloidosis: new combo shows promise in Late-Stage trial

NCT ID NCT01659658

Terminated Disease control Sponsor: Millennium Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 09, 2026 · Updated 23 times

Summary

This study tested a new drug, ixazomib, combined with dexamethasone against standard treatments for people with relapsed or refractory AL amyloidosis, a rare disease where abnormal proteins damage organs. The trial included 177 adults and aimed to see if the new combination improved blood markers and slowed heart or kidney damage. The study was terminated early, but results help guide future research.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for RELAPSED OR REFRACTORY SYSTEMIC LIGHT CHAIN AMYLOIDOSIS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Locations

Alexandra Hospital

Athens, 11528, Greece
Arhus Universitetshospital Arhus Sygehus

Aahus, 800, Denmark
Boston Medical Center

Boston, Massachusetts, 02118, United States
Box Hill Hospital

Box Hill, Victoria, 3128, Australia
Cedars Sinai Medical Center

Los Angeles, California, 90048, United States
Centre Hospitalier et Universitaire de Limoges

Limoges, 87042, France
Centro de Pesquisas Oncologicas

Florianópolis, Santa Catarina, 88034-000, Brazil
Chaim Sheba Medical Center

Ramat Gan, 52621, Israel
Charite - Universitatsmedizin Berlin

Berlin, 12200, Germany
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Clinica Universidad de Navarra

Pamplona, Navarre, 31008, Spain
Columbia University Medical Center

New York, New York, 10032, United States
Cross Cancer Institute

Edmonton, Alberta, T6G 1Z, Canada
Fakultni nemocnice Ostrava

Ostrava, Moravskoslezsk Kraj, 708 52, Czechia
Fondazione IRCCS Policlinico San Matteo di Pavia

Pavia, 2710, Italy
Froedtert and The Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Gachon University Gil Medical Center

Incheon, 405-760, South Korea
Hadasit Medical Research Services and Development Ltd

Jerusalem, 911, Israel
Hopital Claude Huriez

Lille, 5903, France
Hopital Saint Louis

Paris, 75010, France
Hopital de Rangueil

Toulouse, 31059, France
Hospital Clinic de Barcelona

Barcelona, 8036, Spain
Hospital Israelita Albert Einstein

São Paulo, 05652-900, Brazil
Hospital Universitario Clementino Fraga Filho (UFRJ)

Rio de Janeiro, 21941-913, Brazil
Hospital Universitario Puerta de Hierro - Majadahonda

Majadahonda, 28222, Spain
Hospital Universitario de La Princesa

Madrid, 28006, Spain
Hospital Universitario de Salamanca

Salamanca, 37007, Spain
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo

São Paulo, 5403000, Brazil
Hotel Dieu

Nantes, Loire-Atlantique, 44093, France
Indiana University School of Medicine

Indianapolis, Indiana, 46202, United States
Institute of Hematology "Seragnoli" University of Bologna

Bologna, 40138, Italy
Irmandade Da Santa Casa de Misericordia de Sao Paulo

São Paulo, 01223-001, Brazil
Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Maastricht University Medical Center

AZ Maastricht, 620, Netherlands
Manchester Royal Infirmary

Manchester, MI3 9WL, United Kingdom
Mayo Clinic

Rochester, Minnesota, 05590, United States
Meir Medical Center

Kfar Saba, 44281, Israel
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Oxford University Hospitals NHS Trust

Oxford, OX3 7L, United Kingdom
Princess Alexandra Hospital

Woolloongabba, Queensland, 4102, Australia
Princess Margaret Hospital

Toronto, Ontario, M5G2M9, Canada
Queen Elizabeth Hospital

Birmingham, B152TH, United Kingdom
Rabin Medical Center - PPDS

Petah Tikva, 49100, Israel
Rambam Health Corporation

Haifa, 31096, Israel
Rigshospitalet

Copenhagen, 2100, Denmark
Royal Free and University College Medical School

London, NW3 2P, United Kingdom
Samsung Medical Center - PPDS

Seoul, 135-710, South Korea
Seoul National University Hospital

Seoul, 110744, South Korea
Severance Hospital at Yonsei University Health System - PPDS

Seoul, 120-752, South Korea
Sir Charles Gairdner Hospital

Nedlands, Western Australia, 6009, Australia
The Catholic University of Korea, Seoul St Mary's Hospital

Seoul, 137-70, South Korea
Tom Baker Cancer Centre

Calgary, Alberta, T2N 4N2, Canada
Tufts Medical Center

Boston, Massachusetts, 00211, United States
Universitair Medisch Centrum Utrecht

Utrecht, 3508, Netherlands
Universitat Heidelberg

Heidelberg, 69120, Germany
Universitatsklinikum Hamburg Eppendorf

Hamburg, 20246, Germany
University General Hospital of Patras

Pátrai, Achaia, 26500, Greece
University of Chicago

Chicago, Illinois, 60637, United States
University of Cincinnati

Cincinnati, Ohio, 45267, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States
VU Medisch Centrum

Amsterdam, North Holland, 1081 HV, Netherlands
Vancouver General Hospital

Vancouver, British Columbia, V5Z 1M, Canada
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Vseobecna fakultni nemocnice v Praze

Prague, Praha, Hlavni Mesto, 128 08, Czechia
Washington University

St Louis, Missouri, 63110, United States
Westmead Hospital

Westmead, New South Wales, 214, Australia

Conditions

Explore the condition pages connected to this study.

RELAPSED OR REFRACTORY SYSTEMIC LIGHT CHAIN AMYLOIDOSIS