New study explores ivosidenib dosing for cancer patients with organ issues
NCT ID NCT07006688
First seen Jun 25, 2026 · Last updated Aug 07, 2026 · Updated 3 times
Summary
This early-stage study is testing the safety and how the body handles ivosidenib in 30 adults with IDH1-mutated cancers who also have liver or kidney problems. Participants take a daily ivosidenib pill and are monitored closely with blood tests and check-ups. The goal is to learn how organ impairment affects the drug, not to treat the cancer directly.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ivosidenib (oral tablet)
- What this could lead to
- If successful, this could help doctors understand how to safely dose ivosidenib in patients with liver or kidney problems, potentially expanding treatment access.
- What could go wrong
- This is a very early, small Phase 1 study with only 30 participants. It focuses on safety and drug levels, not on curing cancer. Results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Asan Medical Center
RECRUITINGSeoul, 5505, South Korea
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Emory University
RECRUITINGAtlanta, Georgia, 30322, United States
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Fakultni nemocnice Ostrava
RECRUITINGOstrava, 70800, Czechia
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Fakultni nemocnice v Motole FN Motol
RECRUITINGPrague, HlavnÃ- Mesto Praha, 15000, Czechia
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Hospital Universitari Vall d'Hebron
NOT_YET_RECRUITINGBarcelona, 8035, Spain
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Hospital Universitario 12 de Octubre
RECRUITINGMadrid, 28050, Spain
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Hospital de Base de Sao Jose do Rio Preto
RECRUITINGSão José do Rio Preto, São Paulo, 15090-000, Brazil
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Icon Cancer Centre
RECRUITINGSouth Brisbane, Queensland, 4101, Australia
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Instituto do Cancer do Estado de Sao Paulo
RECRUITINGSão Paulo, 01246-000, Brazil
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MD Anderson
RECRUITINGHouston, Texas, 77030, United States
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Royal Adelaide Hospital
RECRUITINGAdelaide, South Australia, 5000, Australia
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START - Hospital HM Nou Delfos
RECRUITINGBarcelona, 8023, Spain
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START Madrid - Fundacion Jimenez Diaz
RECRUITINGMadrid, 28040, Spain
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START Madrid Centro Oncologico Clara Campal Sanchinarro Univesrity Hospital
RECRUITINGMadrid, 28050, Spain
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Seoul National University Bundang Hospital
RECRUITINGSeongnam-si, Gyeonggi-do, 13620, South Korea
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Seoul National University Hospital
RECRUITINGSeoul, 3080, South Korea
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Severence Hospital, Yonsei University Health Systems
RECRUITINGSeoul, 3722, South Korea
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The Ohio State University Wexner Medical Center, The James Cancer Hospital & Solove Research Institute
NOT_YET_RECRUITINGColumbus, Ohio, 43210, United States
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University Hospital Brno
WITHDRAWNBrno, 62500, Czechia
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Vseobecna fakultni nemocnice v Praze
RECRUITINGPrague, 128 00, Czechia
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