New targeted pill shows promise for rare bile duct cancer in small trial
NCT ID NCT06081829
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a daily pill called ivosidenib in 12 Japanese patients with advanced bile duct cancer that has an IDH1 mutation and has already been treated with other therapies. The goal is to see if the drug can stop the cancer from growing for at least 6 months. Participants take the pill once a day and are monitored with scans, blood tests, and checkups.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ivosidenib (a targeted cancer pill)
- What this could lead to
- If successful, this could provide a new oral treatment option for people with a specific genetic subtype of bile duct cancer that has stopped responding to other therapies.
- What could go wrong
- This is a small, early-phase study with only 12 participants, so results may not apply broadly. The drug may not control the cancer for long or could cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hokkaido University Hospital (JPN-006)
Sapporo, 060-8648, Japan
-
Kanagawa Cancer Center (JPN-003)
Yokohama, 241-8515, Japan
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Kumamoto University Hospital (JPN-004)
Kumamoto, 860-8556, Japan
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National Cancer Center Hospital (JPN-001)
Tokyo, Japan
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National Cancer Center Hospital East (JPN-002)
Kashiwa, 277-8577, Japan
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National Hospital Organization Shikoku Cancer Center (JPN-007)
Matsuyama, 791-0280, Japan
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Osaka International Cancer Institute (JPN-005)
Osaka, 541-8567, Japan
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Triple attack on bile duct cancer: chemo, targeted drug, and immunotherapy aim to make the inoperable operable
- New drug CT-95 targets tough cancers in early trial
- Triple therapy takes on bile duct cancer: hope for unresectable cases
- Blood tests and patient surveys could improve bile duct cancer monitoring
- Blocking blood flow before surgery may help remove inoperable bile duct cancer
- Liver-targeted chemo shows promise for tough bile duct cancer