New hope for rare bone cancer: targeted pill slows tumor growth?

NCT ID NCT06127407

Recruiting now Disease control Sponsor: Servier Bio-Innovation LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tests ivosidenib, a daily pill that targets a specific genetic mutation (IDH1), in 136 adults with advanced or metastatic conventional chondrosarcoma that cannot be surgically removed. Participants are randomly assigned to receive either ivosidenib or a placebo. The main goal is to see if the drug delays cancer progression, especially in lower-grade tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ivosidenib
What this could lead to: If successful, this could provide a targeted treatment option to slow tumor growth in people with a rare bone cancer that has few effective therapies.
What could go wrong: This is an early Phase 3 trial with only 136 participants, so results may not apply to all patients. The drug may not improve survival or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chondrosarcoma Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED OR METASTATIC CONVENTIONAL CHONDROSARCOMA WITH AN IDH1 MUTATION, UNTREATED OR PREVIOUSLY TREATED WITH 1 SYSTEMIC TREATMENT REGIMEN

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Aarhus Universitetshospital
RECRUITING

Aarhus, 8200, Denmark
Alberta Health Services
RECRUITING

Calgary, Alberta, T2N-5G2, Canada
Aou Policlinico Paolo Giaccone
RECRUITING

Palermo, 90127, Italy
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Beijing Cancer Hospital
RECRUITING

Beijing, 100142, China
Beijing Jishuitan Hospital
RECRUITING

Beijing, 102208, China
CIONC
RECRUITING

Curitiba, 80810-050, Brazil
Cancer Institute Hospital of Jfcr
RECRUITING

Koto-Ku, Tokyo, 135-8550, Japan
Centre Multidisciplinaire de Oncologie Medicale
RECRUITING

Liège, 4000, Belgium
Centre Oscar Lambret
RECRUITING

Lille, 59020, France
Cepon - Centro de Pesquisas Oncologicas
RECRUITING

Florianópolis, 88034-000, Brazil
Charite Universitatsmedizin
RECRUITING

Berlin, 13353, Germany
Chris O'Brien Lifehouse
NOT_YET_RECRUITING

Camperdown, 2050, Australia
Chris O'Brien Lifehouse
RECRUITING

Camperdown, 2050, Australia
Christie Hospital
RECRUITING

Manchester, M20 4BX, United Kingdom
Churchill Hospital
RECRUITING

Oxford, United Kingdom
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States

Contact Email: •••••@•••••
Cliniques Universitaires St. Luc
RECRUITING

Brussels, 1200, Belgium
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Duke University
RECRUITING

Durham, North Carolina, 27710, United States
Emory Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30308, United States
Flinders Medical Centre
RECRUITING

Bedford Park, 5042, Australia
Fukushima Medical University Hospital
RECRUITING

Fukushima, 960-1295, Japan
Fundação Amaral Carvalho - Jaú/ Sp
RECRUITING

Jaú, 17210-080, Brazil
Helios Klinikum Bad Saarow
RECRUITING

Bad Saarow, 15526, Germany
Henan Cancer Hospital
RECRUITING

Guangzhou, 450003, China
Herlev & Gentofte Hospital
RECRUITING

Herlev, 2730, Denmark
Hokkaido Cancer Center
RECRUITING

Sapporo, Hokkaido, 003-0804, Japan
Hopital de La Timone
RECRUITING

Marseille, 13005, France
Hospital A C Camargo
RECRUITING

São Paulo, 01509-010, Brazil
Hospital Albert Einstein
RECRUITING

São Paulo, 05652-900, Brazil
Hospital Das Clínicas Da Ufmg
RECRUITING

Belo Horizonte, 30130-100, Brazil
Hospital General Universitario Gregorio
RECRUITING

Madrid, 28007, Spain
Hospital Universitario Fundación Jiménez Díaz
RECRUITING

Madrid, 28040, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Valle de Hebrón - Vhio
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario Y Politecnico La Fe
RECRUITING

Valencia, 46026, Spain
Hospital de Amor - Barretos
RECRUITING

Barretos, 14784-400, Brazil
Hospital de Bellvitge - Ico
RECRUITING

L'Hospitalet de Llobregat, 08908, Spain
Hospital de La Santa Creu I Sant Pau
RECRUITING

Barcelona, 08041, Spain
Hôpital Cochin
RECRUITING

Paris, 75014, France
Hôpital Léon Bérard
RECRUITING

Lyon, 69008, France
INSTITUT de CANCEROLOGIE de l'Ouest
RECRUITING

Saint-Herblain, 44805, France
Icesp - Instituto Do Câncer Do Estado de São Paulo
RECRUITING

São Paulo, 01246-000, Brazil
Impar Serviços Hospitalares S.A. - Hospital Nove de Julho
RECRUITING

São Paulo, 01409-902, Brazil
Institut Bergonié
RECRUITING

Bordeaux, 33076, France
Institut Gustave Roussy
RECRUITING

Villejuif, 94800, France
Instituto Nacional Do Câncer - Inca
RECRUITING

Rio de Janeiro, 20220-410, Brazil
Irccs Fondazione Istituto Nazionale Dei Tumori
RECRUITING

Milan, 20133, Italy
Irccs Istituto Ortopedico Rizzoli
RECRUITING

Bologna, 40136, Italy
Istituti Fisioterapici Ospitalieri (Ifo) - Istituto Nazionale Tumori Regina Elena (Ire)
RECRUITING

Roma, 00144, Italy
Istituto Oncologico Veneto Iov - Irccs
RECRUITING

Padova, 35128, Italy
Iuct-Oncopole Institut Universitaire Du Cancer
RECRUITING

Toulouse, 31059, France
Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21287, United States
Kanazawa University Hospital
RECRUITING

Kanazawa, Ishikawa-ken, 920-8641, Japan
Kyushu University Hospital
RECRUITING

Higashi, 812-8582, Japan
Leids Universitair Medisch Centrum
RECRUITING

Leiden, 2333 ZA, Netherlands
Liga Norte Riograndense Contra O Cancer
RECRUITING

Natal, Rio Grande do Norte, 59062-000, Brazil
Lmu Klinikum
RECRUITING

München, 81377, Germany
Mayo Clinic - Jacksonville, Fl
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic - Rochester, Mn
RECRUITING

Rochester, Minnesota, 55905, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Muhc Glen Site
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Nagoya University Hospital
RECRUITING

Shōwaku, Nagoya-shi, Aichi, 466-8560, Japan
National Cancer Center Hospital
RECRUITING

Chuo-ku, Tokyo, 104-0045, Japan
National Taiwan University Hospital
RECRUITING

Taipei, 100225, Taiwan
Nebraska Methodist Hospital
RECRUITING

Omaha, Nebraska, 68118, United States
Niigata University Medical and Dental General Hospital
RECRUITING

Chūōku, Niigata City, 951-8510, Japan
Oita University Hospital
RECRUITING

Yufu-Shi, Oita Prefecture, 879-5593, Japan
Okayama University Hospital
RECRUITING

Okayama, 700-8558, Japan
Oregon Health & Science University Knight Cancer Institute
RECRUITING

Portland, Oregon, 97239, United States
Osaka International Cancer Institute
RECRUITING

Chūōku, Osaka-shi, Osaka, 700-8558, Japan
Ospedale Santo Stefano
RECRUITING

Prato, 59100, Italy
Pan American Center For Oncology Trials, LLC
RECRUITING

Rio Piedras, 00935, Puerto Rico
Policlinico Universitario Campus Biomedico
RECRUITING

Roma, 00128, Italy
Princess Alexandra Hospital
RECRUITING

Woolloongabba, 4102, Australia
Radboud Umc
RECRUITING

Nijmegen, 6525 GA, Netherlands
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
RECRUITING

Chicago, Illinois, 60611-5975, United States
Royal Marsden Hospital
RECRUITING

London, United Kingdom
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
San Luigi Gonzaga University Hospital of Turin
RECRUITING

Orbassano, 10043, Italy
Sarcoma Oncology Research Center
RECRUITING

Santa Monica, California, 90403, United States
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Severance Hospital
RECRUITING

Seoul, 03722, South Korea
Shanghai Changzheng Hospital
RECRUITING

Shang'ai, Shanghai Municipality, 200000, China
Shanghai General Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200080, China
Shanghai Ruijin Hospital
RECRUITING

Shanghai, Shanghai Municipality, 200025, China
Sir Charles Gairdner Hospital
RECRUITING

Nedlands, 6009, Australia
St Vincent'S Hospital Melbourne
RECRUITING

Fitzroy, 3065, Australia
Taipei Veterans General Hospital
RECRUITING

Taipei, 112201, Taiwan
The First Affiliated Hospital of Sun Yat-Sen University
RECRUITING

Guangzhou, Guangdong, 510080, China
The Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
The Second Affiliated Hospital Zhejiang University School of Medical
RECRUITING

Hangzhou, Zhejiang, 310025, China
The Univeristy of Texas Md Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
The Washington University
RECRUITING

St Louis, Missouri, 63110, United States
U.Z. Gent
RECRUITING

Ghent, 9000, Belgium
UCLH
RECRUITING

London, United Kingdom
Ukm - Sarkom-Zentrum
RECRUITING

Münster, 48149, Germany
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
RECRUITING

Wuhan, Hubei, 430023, China
Universitaetsklinikum Ulm
RECRUITING

Ulm, 89081, Germany
Universitair Medisch Centrum Groningen (Umcg)
RECRUITING

Groningen, 9713 GZ, Netherlands

Contact Email: •••••@•••••
Universitatsklinikum Hamburg-Eppendorf
RECRUITING

Hamburg, 20246, Germany
University Health Network
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
University of Colorado Cancer Center
RECRUITING

Aurora, Colorado, 80045, United States
University of Iowa Hospitals & Clinics- Holden Comprehensive Cancer Center
RECRUITING

Iowa City, Iowa, 52242, United States
University of Miami
RECRUITING

Miami, Florida, 33136-1002, United States
University of Pittsburgh Medical Center-Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
Universitätsklinikum Carl Gustav Carus Dresden
RECRUITING

Dresden, 01307, Germany

Contact Email: •••••@•••••
Universitätsmedizin Mannheim (Umm)
RECRUITING

Mannheim, 68167, Germany
Usc Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
West China Hopital of Sichuan University
RECRUITING

Chengdu, Sichuan, 610041, China
Western General Hospital
RECRUITING

Edinburgh, United Kingdom
Yale Cancer Center
RECRUITING

New Haven, Connecticut, 06511, United States