Bile duct cancer combo trial stopped early – only safety results available
NCT ID NCT05921760
First seen Feb 15, 2026 · Last updated May 14, 2026 · Updated 11 times
Summary
This early-stage trial tested a combination of ivosidenib (a targeted drug) with two immunotherapy drugs (nivolumab and ipilimumab) in people with advanced bile duct cancer that has a specific IDH1 gene mutation. The study was stopped by the sponsor before the expansion phase, so only 7 participants were enrolled in the safety lead-in part. The main goal was to check safety and find the right dose, but no conclusions about effectiveness can be drawn.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Sidney Kimmel Comprehensive Cancer Center At Johns Hopkins
Baltimore, Maryland, 21231, United States
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UCLH
London, NW1 2PG, United Kingdom
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UCSF - Medical Center at Mission Bay
San Francisco, California, 94158, United States
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Ucsf Helen Diller Family Comprehensive Cancer Center
San Francisco, California, 94158, United States
Conditions
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