New hope for leukemia patients too frail for chemo: targeted combo under study
NCT ID NCT05907057
First seen May 10, 2026 · Last updated May 12, 2026 · Updated 1 time
Summary
This study tests the safety of combining ivosidenib and azacitidine in adults newly diagnosed with a specific genetic subtype of acute myeloid leukemia (IDH1-mutated) who cannot receive intensive chemotherapy. About 245 participants will receive the drug combination. The goal is to see if this targeted approach can control the disease with fewer side effects than standard strong chemo.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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AKH - Medizinische Universität Wien
COMPLETEDVienna, 1090, Austria
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Amsterdam UMC
RECRUITINGAmsterdam, 1105 AZ, Netherlands
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Azienda Ospedaliera di Perugia Ospedale S. Maria della Misericordia
RECRUITINGPerugia, 06135, Italy
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Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)
RECRUITINGBrescia, 25123, Italy
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CHU Angers - Hôpital Hôtel Dieu
NOT_YET_RECRUITINGAngers, Liore, 49100, France
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CHU CAEN - Hôpital de la Côte de Nacre
RECRUITINGCaen, Calvados, 14033, France
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CHU Rennes - Hopital Pontchaillou
NOT_YET_RECRUITINGRennes, Ille Et Vilaine, 35033, France
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CHU de Toulouse pt
RECRUITINGToulouse, Haute Garonne, 31059, France
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IRCCS Istituto Scientifico Romagnolo Per Lo Studio Dei Tumori "Dino Amadori" - IRST
RECRUITINGMeldola, Forli-Cesena, 47014, Italy
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IRCCS Ospedale Policlinico San Martino
RECRUITINGGenova, 16132, Italy
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Institut Paoli Calmettes
RECRUITINGMarseille, Bouches-du-Rhône, 13273, France
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Klinikum Wels-Grieskirchen GmbH
COMPLETEDWels, 4600, Austria
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Meander Medisch Centrum
RECRUITINGAmersfoort, 3818 AZ, Netherlands
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Rijnstate
NOT_YET_RECRUITINGArnhem, 6815 AD, Netherlands
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Universitair Medisch Centrum Groningen
RECRUITINGGroningen, 9713 GZ, Netherlands
Conditions
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