Can a simple fertility procedure break the cycle of unexplained pregnancy loss?
NCT ID NCT07759609
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This trial asks whether intrauterine insemination (IUI) can improve the chances of a successful pregnancy for couples who have experienced unexplained pregnancy loss. It will enroll 558 couples, randomly assigning them to either IUI or natural conception, and track outcomes like early miscarriage, clinical pregnancy, and live birth rates. The goal is to provide clearer evidence on whether IUI should be a standard option for these couples.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Intrauterine insemination (IUI), a procedure where processed sperm is placed directly into the uterine cavity around ovulation to increase the chance of conception.
- What this could lead to
- If IUI proves effective, it could offer couples with unexplained pregnancy loss a simple, low-tech option to improve their chances of a successful pregnancy.
- What could go wrong
- This is an early-stage question; IUI may not improve outcomes over natural conception, and the trial's success depends on many factors, including the couple's specific fertility profile.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Beijing Amcare Beisanhuan Women's & Children's Hospital
NOT_YET_RECRUITINGBeijing, Beijing Municipality, China
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Hebei Reproductive Health Hospital
NOT_YET_RECRUITINGShijiazhuang, Hebei, China
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Lanzhou university second hosipital
RECRUITINGLanzhou, Gansu, China