New drug combo tested to tame dangerous transplant complication

NCT ID NCT03139604

Completed Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

Summary

This study tested whether adding the drug itacitinib to standard steroid treatment works better for controlling acute graft-versus-host disease (GVHD) in people who recently had a stem cell transplant. It involved 439 participants who developed moderate to severe GVHD. The goal was to see if the combination improves response rates and reduces the need for long-term steroid use.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Locations

A.O.U. Città della Salute e della Scienza di Torino

Torino, 10126, Italy
ASST Grande Ospedale Metropolitano Niguarda

Milan, 20162, Italy
AZ Delta

Roeselare, 8800, Belgium
Addenbrooke's Hospital

Cambridge, CB2 0QQ, United Kingdom
Advocate Lutheran General Hospital - Oncology Specialists SC

Park Ridge, Illinois, 60028, United States
Auckland District Health Board

Auckland, 1023, New Zealand
Azienda Ospedaliera Bianchi-Melacrino-Morelli Ospedali Riuniti

Reggio Calabria, 89124, Italy
Azienda Ospedaliero Universitaria (AOU) Policlinico - Vittorio Emanuele - Presidio Ospedaliero Ferrarotto Alessi

Catania, 95124, Italy
Azienda Ospedaliero Universitaria Careggi

Florence, 50134, Italy
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII

Bergamo, 24127, Italy
Azienda Unità Sanitaria Locale di Reggio Emilia

Reggio Emilia, 42123, Italy
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
C.T.M.O. Ospedale Roberto Binaghi ATS Cagliari

Cagliari, 09126, Italy
CHRU de Lille-Hopital Claude Huriez

Lille, 59037, France
CHU Amiens Picardie - Hopital Sud

Amiens, 80054, France
CHU de Nancy

Vandœuvre-lès-Nancy, 54500, France
Casa di Cura La Maddalena

Palermo, 90146, Italy
Centro Hospitalar Lisboa Norte - Hospital de Santa Maria

Lisbon, 1649-035, Portugal
Centrum Onkologii- Instytut w Gliwicach

Gliwice, 44-101, Poland
Chaim Sheba Medical Center

Ramat Gan, 5262160, Israel
China Medical University Hospital

Taichung, 40447 ROC, Taiwan
Clinica Ematologica CTA, Ospedale "San Gerardo" di Monza

Monza, 20900, Italy
Cliniques Universitaires Saint-Luc

Brussels, 1200, Belgium
Columbia University

New York, New York, 10032, United States
Complejo Hospitalario Universitario de Granada - Hospital Universitario Virgen de las Nieves

Granada, 18014, Spain
Dana Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States
Florida Hospital Cancer Institute

Orlando, Florida, 32804, United States
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico di Milano

Milan, 20122, Italy
Fondazione IRCCS Policlinco San Matteo

Pavia, 27100, Italy
General Hospital Sint-Jan Brugge-Oostend

Bruges, 8000, Belgium
General Hospital of Thessaloniki G. Papanikolaou - Hematology Department

Chortiatis, 57010, Greece
Greenville Health System

Greenville, South Carolina, 29615, United States
Hadassah Hebrew University Medical Center Ein Karem

Jerusalem, 9112001, Israel
Hammersmith Hospital

London, W12 0HS, United Kingdom
Helsinki University Central Hospital

Helsinki, 00290, Finland
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Hopital Haut Leveque - CHU Bordeaux - Maladies du sang

Pessac, 33604, France
Hopital Saint Louis

Paris, 75010, France
Hopital de Hautepierre

Strasbourg, 67098, France
Hopital universitaire du Sart Tilman de Liege

Liège, 4000, Belgium
Hopitaux Universitaires de Geneve

Geneva, 1211, Switzerland
Hospital Clinic i Provincial de Barcelona

Barcelona, 08036, Spain
Hospital Clinico Universitario de Valencia

Valencia, 46010, Spain
Hospital Clinico de Santiago de Compostela

Santiago de Compostela, 15706, Spain
Hospital General Universitario Gregorio Maranon

Madrid, 28007, Spain
Hospital Universitari i Politecnic La Fe

Valencia, 46026, Spain
Hospital Universitario La Paz

Madrid, 28046, Spain
Hospital Universitario Marques de Valdecilla

Santander, 39008, Spain
Hospital Universitario Puerta de Hierro Majadahonda

Madrid, 28222, Spain
Hospital Universitario Ramon y Cajal

Madrid, 28034, Spain
Hospital Universitario Vall d'Hebron

Barcelona, 08035, Spain
Hospital Universitario Virgen del Rocio

Seville, 41013, Spain
Hospital Universitario de Donostia

San Sebastián, 20014, Spain
Hospital Universitario de Salamanca

Salamanca, 37007, Spain
Hospital de la Santa Creu i Sant Pau - Servei de Hematologia Clinica

Barcelona, 08025, Spain
Hotel Dieu Hospital - Hematologie

Nantes, 44000, France
IRCCS Ospedale San Raffaele

Milan, 20132, Italy
Indiana Blood and Marrow Transplant

Indianapolis, Indiana, 46237, United States
Indiana University (IU) Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202, United States
Institut Claudius Regaud-Universitaire du Cancer Toulouse Oncopol

Toulouse, 31059, France
Institut Jules Bordet

Brussels, 1000, Belgium
Instituto Catalan de Oncologia - Hospital Duran i Reynals

Barcelona, 08907, Spain
Instituto Portugues de Oncologia de Lisboa Francisco Gentil EPE (IPO-Lisboa)

Lisbon, 1099-023, Portugal
Instituto Portugues de Oncologia do Porto Francisco Gentil, EPE

Porto, 4200-072, Portugal
Istituto Clinico Humanitas

Rozzano, 20089, Italy
Jessa Ziekenhuis

Hasselt, 3500, Belgium
John Theurer Cancer Center At Hackensack UMC

Hackensack, New Jersey, 07601, United States
Klinika Transplantacji Komorek Krwiotworczych - Instytut Hematologii i Transfuzjologii

Warsaw, 02-776, Poland
Levine Cancer Institute

Charlotte, North Carolina, 28204, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Methodist Healthcare Foundation

Memphis, Tennessee, 38104, United States
Northwell Health

Lake Success, New York, 11042, United States
Nottingham University Hospitals

Nottingham, NG5 1PB, United Kingdom
Oncology Hematology in Cincinnati

Cincinnati, Ohio, 45236, United States
Ordensklinikum Linz GmbH Elisabethinen

Linz, 4020, Austria
Oregon Health & Science University (OHSU)

Portland, Oregon, 97239-3098, United States
Presidio Ospedaliero Pescara

Pescara, 65124, Italy
Rambam Health Care Campus

Haifa, 3109601, Israel
Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903-2681, United States
SOC Clinica Ematologica, Azienda Ospediero-Universitaria di Udine

Udine, 33100, Italy
Sarah Cannon Research Institute, LLC (SCRI)

Nashville, Tennessee, 37203, United States
Seoul National University Hospital

Seoul, 3080, South Korea
Spectrum Health

Grand Rapids, Michigan, 49503, United States
St Vincents Hospital Sydney Limited

Darlinghurst, NSW 2010, Australia
Stanford Cancer Center

Stanford, California, 94305, United States
Stony Brook University Medical Center

Stony Brook, New York, 11794, United States
Tel Aviv Sourasky Medical Center

Tel Aviv, 6423906, Israel
Texas Transplant Institute

San Antonio, Texas, 78229, United States
The Ohio State University (OSU)

Columbus, Ohio, 43210, United States
Thomas Jefferson University

Philadelphia, Pennsylvania, 19107, United States
Tufts Medical Center

Boston, Massachusetts, 02111, United States
Tulane University Medical Center

New Orleans, Louisiana, 70112, United States
UHKT Prague - Institute of Hematology and Blood Transfusion

Prague, 128 20, Czechia
UKGM Marburg Innere Medizin: Haematologie Onkolog

Marburg, 35043, Germany
Universitaet zu Koln - Universitaetsklinikum Koeln (Uniklinik Koeln)

Cologne, 50924, Germany
Universitaetsklinikum Leipzig

Leipzig, 4103, Germany
Universitaetsmedizin der Johannes Gutenberg

Mainz, 55131, Germany
Universitaetsspital Zuerich - Klinik fuer Haematology

Zurich, CH-8091, Switzerland
Universitair Ziekenhuis Gent (UZG)

Ghent, 9000, Belgium
Universitatsklinikum Freiburg - Klinik fur Innere Medizin I

Freiburg im Breisgau, 79106, Germany
Universitatsklinikum Hamburg - Eppendorf

Hamburg, 20246, Germany
University Clinic Carl Gustav Carus, Technical University Dresden

Dresden, 1307, Germany
University Hospital of Wales

Cardiff, CF14 4XW, United Kingdom
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
University of California, Los Angeles (UCLA) - Medical Center

Los Angeles, California, 90095-1678, United States
University of California, San Diego (UCSD) - Moores Cancer Center

La Jolla, California, 92093-0698, United States
University of Chicago

Chicago, Illinois, 60637, United States
University of Colorado - Aurora Cancer Center

Aurora, Colorado, 80045, United States
University of Florida (UF) - Division of Hematology & Oncology

Gainesville, Florida, 32610, United States
University of Illinois at Chicago

Chicago, Illinois, 60612, United States
University of Iowa

Iowa City, Iowa, 52242, United States
University of Kansas Cancer Center

Westwood, Kansas, 66205, United States
University of Maryland Medical Center

Baltimore, Maryland, 21201, United States
University of Miami - Sylvester Cancer Center

Miami, Florida, 33136, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198-7680, United States
University of Oklahoma - Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Pittsburgh Medical Center (UPMC) - Hillman Cancer Center

Pittsburgh, Pennsylvania, 15232, United States
University of Rome La Sapienza

Roma, 00161, Italy
University of Southern California

Los Angeles, California, 90033, United States
University of Virginia Medical Center

Charlottesville, Virginia, 22908, United States
Universtity Hospital Basel - Haematology

Basel, 4031, Switzerland
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Wake Forest Baptist Medical Center - Wake Forest University School of Medicine

Winston-Salem, North Carolina, 27157, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
ZNA Stuivenberg

Antwerp, 2060, Belgium

Conditions

Explore the condition pages connected to this study.

GRAFT-VERSUS-HOST DISEASE (GVHD)