New pill may ease daily struggles of muscle weakness disease

NCT ID NCT06517758

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Oct 31, 2025 · Last updated May 14, 2026 · Updated 29 times

Summary

This study tests an oral drug called iptacopan in people with generalized myasthenia gravis (gMG), a condition causing muscle weakness. About 146 adults with a specific antibody (AChR+) will receive either iptacopan or a placebo for 6 months, alongside their usual treatments. The goal is to see if iptacopan improves daily activities and reduces symptoms like droopy eyelids, trouble swallowing, and limb weakness.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Augusta University Georgia
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Augusta, Georgia, 30912, United States

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California Pacific Medical Center
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Sacramento, California, 94115, United States

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Center for Neurological Disorders G
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Greenfield, Wisconsin, 53228-1321, United States

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Central TX Neuro Consultants P A
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Round Rock, Texas, 78681, United States

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Duke University Medical Center
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Durham, North Carolina, 27710, United States

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Fullerton Neuro and Headache Ctr
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Fullerton, California, 92835, United States

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Hawaii Pacific Neuroscience LLC
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Honolulu, Hawaii, 96817, United States
Honor Health Research Institute
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Scottsdale, Arizona, 85258, United States

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Mid Atlantic Epilepsy and Sleep Ctr
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Bethesda, Maryland, 20817-1807, United States

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Nerve and Muscle Center of Texas
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Houston, Texas, 77030, United States

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Neurology Offices Of South Florida
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Boca Raton, Florida, 33428, United States
Neuroscience Research Ctr
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Canton, Ohio, 44718, United States
Novartis Investigative Site
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Buenos Aires, C1012AAR, Argentina
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Córdoba, X5004AOA, Argentina
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Porto Alegre, Rio Grande do Sul, 90560-030, Brazil
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Joinville, Santa Catarina, 89202-165, Brazil
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São Paulo, 04038-002, Brazil
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Hefei, Anhui, 230001, China
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Guangzhou, Guangdong, 510515, China
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Shenzhen, Guangdong, 518053, China
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Shijiazhuang, Hebei, 50030, China
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Changsha, Hunan, 410008, China
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Suzhou, Jiangsu, 215004, China
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Nanchang, Jiangxi, 330006, China
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Xi'an, Shaanxi, 710075, China
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Xianyang, Shaanxi, 712000, China
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Beijing, 065001, China
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Beijing, 100034, China
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Beijing, 100730, China
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Fujian, 350001, China
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Jinan, 250012, China
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Copenhagen, DK-2100, Denmark
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Limoges, Haute Vienne, 87000, France
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Garches, 92380, France
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Nice, 06001, France
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Paris, 75013, France
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Paris, 75940, France
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Würzburg, Bavaria, 97070, Germany
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Frankfurt am Main, Hesse, 60590, Germany
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Bochum, 44789, Germany
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Athens, 115 28, Greece
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Chaïdári, 124 62, Greece
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Larissa, 411 10, Greece
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Pátrai, 265 04, Greece
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Thessaloniki, 54636, Greece
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Haifa, 3109601, Israel
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Jerusalem, 9112001, Israel
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Bologna, BO, 40139, Italy
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Florence, FI, 50134, Italy
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Genova, GE, 16132, Italy
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Milan, MI, 20133, Italy
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Palermo, PA, 90127, Italy
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Palermo, PA, 90146, Italy
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Roma, RM, 00133, Italy
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Roma, RM, 00135, Italy
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Roma, RM, 00189, Italy
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Orbassano, TO, 10043, Italy
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Naples, 80131, Italy
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Narita, Chiba, 286-8520, Japan
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Sapporo, Hokkaido, 0630005, Japan
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Nishinomiya, Hyōgo, 6638501, Japan
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Hanamaki, Iwate, 0250082, Japan
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Sendai, Miyagi, 9838520, Japan
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Suita, Osaka, 565-0871, Japan
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Higashi-Matsuyama, Saitama, 355-0005, Japan
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Shinjuku Ku, Tokyo, 160-0023, Japan
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Chiba, 2608677, Japan
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Fukuoka, 8128582, Japan
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Fukushima, 9601295, Japan
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Hiroshima, 7348551, Japan
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Lublin, Lublin Voivodeship, 20-064, Poland
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Warsaw, Masovian Voivodeship, 02-676, Poland
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Krakow, POL, 31-505, Poland
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Katowice, Silesian Voivodeship, 40-650, Poland
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Bydgoszcz, 85-065, Poland
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Katowice, 40-689, Poland
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Krakow, 31-870, Poland
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Lublin, 20-410, Poland
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Poznan, 61-731, Poland
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Rzeszów, 35-055, Poland
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Warsaw, 01-684, Poland
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Lisbon, 1349-019, Portugal
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Lisbon, 1649-035, Portugal
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Porto, 4099-001, Portugal
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Vila Nova de Gaia, 4434 502, Portugal
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Belgrade, 11000, Serbia
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Niš, 18108, Serbia
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Daegu, 41404, South Korea
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Gwangju, 61469, South Korea
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Seoul, 03722, South Korea
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Seoul, 04763, South Korea
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Santiago Compostela, A Coruna, 15706, Spain
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L'Hospitalet de Llobregat, Barcelona, 08907, Spain
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Alicante, 03010, Spain
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Barcelona, 08036, Spain
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Lleida, 25198, Spain
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Madrid, 28006, Spain
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Málaga, 29010, Spain
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Valencia, 46026, Spain
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Inverness, Invernesshire, IV2 3RE, United Kingdom
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Ilford, London, IG1 4HP, United Kingdom
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Swinton, Manchester, M27 8FF, United Kingdom
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Birmingham, West Midlands, B15 2TH, United Kingdom
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Liverpool, L9 7LT, United Kingdom
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London, SW17 0QT, United Kingdom
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Southampton, SO16 6YD, United Kingdom
Ohio State University Medical Center
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Columbus, Ohio, 43210, United States
Penn Presbyterian Medical Center
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Philadelphia, Pennsylvania, 19104, United States

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Prairie Heart Institute
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Springfield, Illinois, 62769, United States

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SC3 Research Pasadena
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Pasadena, California, 91105, United States

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Superior Associates in Research LLC
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Hialeah, Florida, 33012, United States
University of Chicago Medical Centr
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Chicago, Illinois, 60637, United States

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Vanderbilt University Medical CenterX
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Nashville, Tennessee, 37221, United States

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Conditions

Explore the condition pages connected to this study.

GENERALIZED MYASTHENIA GRAVIS