Cure My Disease

Don't miss your cure!

 Log in / Sign up

Can a common asthma drug help kids with exercise breathing problems?

NCT ID NCT07394036

Symptom relief Sponsor: Cook Children's Health Care System Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a single dose of ipratropium bromide, a drug often used for asthma, can reduce shortness of breath during exercise in 50 children and teens with Exercise-Induced Laryngeal Obstruction (EILO). Participants will inhale the drug or a placebo before intense exercise, and researchers will measure their breathlessness and throat obstruction. The goal is to see if this treatment can make exercise easier for kids with this condition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ipratropium bromide
What this could lead to
If it works, this could point toward a treatment to reduce breathlessness during exercise for children with EILO.
What could go wrong
This is a small, early-phase trial with only 50 participants. The drug may not work better than placebo, and results may not apply to all children with EILO.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

8 to 17 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients must be diagnosed with EILO confirmed by Continuous Laryngoscopy During Exercise * Patients must be able to complete exercise testing * Patients must report dyspnea * Patients must have given assent with parental consent, understand all study procedures, and comply with them for the entire length of the study. Exclusion Criteria: * Patients that do not have EILO. * Patients who did not undergo diagnostic CPET with CLE. * Patients with hypersensitivity to atropine or its derivatives due to structural similarity with ipratropium bromide. * Patients with a history of atrial flutter and/or fibrillation * Patients taking anticholinergic medications that cannot be paused for 24 hours. * Unable to perform exercise tests * Current drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements. * Inability or unwillingness of patient or parent/legally authorized representative to give written informed consent.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Dyspnea during activity are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dyspnea during activity Exercise-induced laryngeal obstruction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Cook Children's Pulmonology (Exercise Respiratory Center)

    Prosper, Texas, 75078, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.