Could a freezing device loosen stiff muscles? new trial begins
NCT ID NCT06340451
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a device called iovera® that uses cold to calm overactive nerves causing muscle tightness in the arm and shoulder. About 132 adults with spasticity from a brain or spinal condition will get either the real device or a sham (fake) treatment. Researchers will measure changes in muscle stiffness over time to see if the device helps.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
iovera® system (a device that delivers cold therapy to nerves to reduce muscle tightness)
What this could lead to
If it works, this could offer a non-drug option to reduce arm and shoulder stiffness in people with spasticity from brain or spinal conditions.
What could go wrong
This is an early-stage study with only 132 people, and it uses a sham comparison, so the real benefit may be small or no better than placebo. The device is temporary and may not work for everyone.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Center for Neurological Disorders - Gamma Therapeutic Center
RECRUITINGGreenfield, Wisconsin, 53228, United States
Contact
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Cooper University Healthcare
RECRUITINGCamden, New Jersey, 08103, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Froedtert and Medical College of Wisconsin - Milwaukee
RECRUITINGMilwaukee, Wisconsin, 53226-3548, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Kansas Institute of Research - Kansas City Bone & Joint Clinic
RECRUITINGOverland Park, Kansas, 66211, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Moss Rehab Physical Medicine Associates
RECRUITINGElkins Park, Pennsylvania, 19027, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mount Sinai Health System - Faculty Practice Associates (FPA)
ACTIVE_NOT_RECRUITINGNew York, New York, 10029-6501, United States
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Nova Clinical Research, LLC
RECRUITINGBradenton, Florida, 34209, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Rancho Los Amigos National Rehabilitation Center
RECRUITINGDowney, California, 90242, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Sarasota Memorial Hospital (SMH)
RECRUITINGSarasota, Florida, 34239-2921, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shepherd Center
RECRUITINGAtlanta, Georgia, 30309, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Source Healthcare - Santa Monica
RECRUITINGSanta Monica, California, 90403, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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St. Luke's Rehabilitation Institute/Main Campus
RECRUITINGSpokane, Washington, 99202, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Missouri Health Care - University Hospital
RECRUITINGColumbia, Missouri, 65212-0001, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Pittsburgh Medical Center (UPMC) - Presbyterian Hospital
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Texas Health Houston/TIRR
RECRUITINGHouston, Texas, 77030, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Texas Southwestern Medical Center
RECRUITINGDallas, Texas, 75390, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Virginia iSpine Physicians, PC
RECRUITINGRichmond, Virginia, 23238, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Washington University School of Medicine
ACTIVE_NOT_RECRUITINGSt Louis, Missouri, 63110-1032, United States