Could a freezing device loosen stiff muscles? new trial begins

NCT ID NCT06340451

Ongoing Symptom relief Sponsor: Pacira Pharmaceuticals, Inc Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 07, 2026 · Updated 3 times

Summary

This study tests a device called iovera® that uses cold to calm overactive nerves causing muscle tightness in the arm and shoulder. About 132 adults with spasticity from a brain or spinal condition will get either the real device or a sham (fake) treatment. Researchers will measure changes in muscle stiffness over time to see if the device helps.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: iovera® system (a device that delivers cold therapy to nerves to reduce muscle tightness)
What this could lead to: If it works, this could offer a non-drug option to reduce arm and shoulder stiffness in people with spasticity from brain or spinal conditions.
What could go wrong: This is an early-stage study with only 132 people, and it uses a sham comparison, so the real benefit may be small or no better than placebo. The device is temporary and may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Muscle Spasticity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SPASTICITY, CEREBRAL OR SPINAL CONDITION

Contacts and locations

Locations

Center for Neurological Disorders - Gamma Therapeutic Center

Greenfield, Wisconsin, 53228, United States
Cooper University Healthcare

Camden, New Jersey, 08103, United States
Froedtert and Medical College of Wisconsin - Milwaukee

Milwaukee, Wisconsin, 53226-3548, United States
Kansas Institute of Research - Kansas City Bone & Joint Clinic

Overland Park, Kansas, 66211, United States
Moss Rehab Physical Medicine Associates

Elkins Park, Pennsylvania, 19027, United States
Mount Sinai Health System - Faculty Practice Associates (FPA)

New York, New York, 10029-6501, United States
Nova Clinical Research, LLC

Bradenton, Florida, 34209, United States
Rancho Los Amigos National Rehabilitation Center

Downey, California, 90242, United States
Sarasota Memorial Hospital (SMH)

Sarasota, Florida, 34239-2921, United States
Shepherd Center

Atlanta, Georgia, 30309, United States
Source Healthcare - Santa Monica

Santa Monica, California, 90403, United States
St. Luke's Rehabilitation Institute/Main Campus

Spokane, Washington, 99202, United States
University of Missouri Health Care - University Hospital

Columbia, Missouri, 65212-0001, United States
University of Pittsburgh Medical Center (UPMC) - Presbyterian Hospital

Pittsburgh, Pennsylvania, 15213, United States
University of Texas Health Houston/TIRR

Houston, Texas, 77030, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States
Virginia iSpine Physicians, PC

Richmond, Virginia, 23238, United States
Washington University School of Medicine

St Louis, Missouri, 63110-1032, United States