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Can a toothpaste whiten teeth in 90 seconds?

NCT ID NCT06800443

Symptom relief Sponsor: Unilever R&D Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time

Summary

Researchers test several silica-based fluoride toothpastes that contain whitening ingredients like blue covarine, green covarine, clay, and charcoal. Adults with natural upper front teeth brush with one toothpaste at each visit, and cameras measure tooth colour before and right after brushing. The study compares these prototypes with a control toothpaste to see which, if any, change tooth whiteness.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
silica-based fluoride toothpastes with whitening ingredients such as blue covarine, green covarine, clay, and charcoal
What this could lead to
If the whitening prototypes work, they could offer a quick way to make teeth look whiter immediately after brushing.
What could go wrong
This is a small, short-term cosmetic study. Any colour change may be slight, temporary, and not noticeable in everyday life, and results may not apply to all tooth types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

68 people

The number who actually took part.

Started

Dec 2018

Finished

Jan 2019

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Two upper central incisors must be natural. * The two upper central incisors must be within the colours of 2M2, 3R1.5, 2R2.5, 3L1.5, 2L2.5, 4M1, 2M3, 3M2, 4R1.5, 4L1.5, 3L2.5, 3R2.5, 5M1, 4M2, 3M3 from VITA 3D-MASTER Shade Guide. * The two upper central incisors must be free of intrinsic stain e.g. caused by tetracycline, fluorosis etc. * The two upper central incisors must be extrinsic stain free. * Willing to sign an informed consent form and complete a medical history questionnaire. Exclusion Criteria: * Two upper central incisors have any caps, crowns, veneers or cracks in the teeth, have excessive gum recession, or have restorations on the distal, mesial, buccal, incisor edge in the opinion of the dentist and technician. * Smoker (including e-cigarettes) or chews tobacco. * Are diabetic * Currently pregnant or breast feeding. * Currently having orthodontics bands, partial removable dentures. * Currently experiencing severe oral problems such as untreated caries, gingivitis or periodontal disease. * Regular use of medication, which in the opinion of the study dentist, could interfere with study objectives. * Known allergies to the toothpaste ingredients or to any dental materials. * Use of tooth bleaching products in the past 6 months. * Have been using whitening oral care products in the last 12 weeks or had a scale and polish in the last 3 months. * Have or have had a medical condition that in the opinion of the study dentist would make them unsuitable for inclusion.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Tooth color

Contacts and locations

Locations

  • SPRIM China

    Shanghai, China

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