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Could a gas calm kids on ventilators and cut delirium?

NCT ID NCT05867472

Recruiting now Symptom relief Sponsor: Sunnybrook Health Sciences Centre Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tests whether using inhaled sedatives (like isoflurane gas) instead of standard IV sedatives can reduce delirium—extreme confusion—in children who need a breathing machine. The study will enroll 60 children aged 1 month to 18 years in intensive care. The main goal is to see if families and healthcare teams accept the study plan, not yet to prove the treatment works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Isoflurane (inhaled sedative)
What this could lead to
If this pilot shows the study plan works, it could lead to a larger trial testing whether inhaled sedatives reduce delirium and improve brain outcomes in critically ill children.
What could go wrong
This is a small pilot study (60 participants) focused on feasibility, not on proving the treatment works. The results may not apply to all children, and there are risks like drug allergy or equipment issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Respiratory Aspiration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANESTHETICS, INHALATION INTENSIVE CARE UNITS, PEDIATRIC MECHANICALLY VENTILATED, CRITICALLY ILL CHILDREN

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Children's Hospital - London Health Sciences Centre

    RECRUITING

    London, Ontario, N6A 5W9, Canada

  • McMaster Children's Hospital

    RECRUITING

    Hamilton, Ontario, L8N 3Z5, Canada

  • The Hospital for Sick Children (SickKids)

    RECRUITING

    Toronto, Ontario, M5G 1X8, Canada

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