New inhaled treatment aims to halt deadly lung scarring

NCT ID NCT06329401

Recruiting now Disease control Sponsor: Avalyn Pharma Inc. Source: ClinicalTrials.gov ↗

Summary

This study is testing whether an inhaled version of a medication called pirfenidone (AP01) can slow the progression of progressive pulmonary fibrosis (PPF), a serious lung scarring disease. About 375 participants will be randomly assigned to receive either a high dose, a low dose, or a placebo (inactive substance) for 52 weeks, in addition to their standard care. The main goal is to see if the inhaled treatment can better preserve lung function, measured by breathing tests, compared to the placebo.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

A.O.U. Policlinico G. Rodolico
RECRUITING

Catania, Sicily, 95123, Italy
A.O.U. delle Marche - Ospedale di Torrette
RECRUITING

Torrette, Ancona, 60126, Italy
APHP - Hopital Bicetre
RECRUITING

Le Kremlin-Bicêtre, 94270, France
Accellacare
RECRUITING

Wilmington, North Carolina, 28401, United States
Alfred Health
RECRUITING

Melbourne, Victoria, 3004, Australia
AppleTreeClinics Network
RECRUITING

Lodz, Łódź Voivodeship, 90-349, Poland
Azienda Ospedaliera dei Colli - Ospedale Monaldi
RECRUITING

Naples, Campania, 80131, Italy
Azienda Sanitaria Universitaria Giuliano Isontina
RECRUITING

Venezia, Giulia, 34149, Italy
Bay of Plenty Clinical School
RECRUITING

Tauranga, South Tauranga, 3112, New Zealand
Baylor College of Medicine
RECRUITING

Houston, Texas, 77030, United States
Baylor Scott & White Research Institute, Baylor University Medical Center
RECRUITING

Dallas, Texas, 75246, United States
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
Birmingham Heartlands Hospital
RECRUITING

Birmingham, Heartlands, B95SS, United Kingdom
C-TRIC Altnagelvin Hospital
RECRUITING

Londonderry, Northern Ireland, BT46, United Kingdom
CHU Angers
RECRUITING

Angers, 49933, France
CHU Tours
RECRUITING

Tours, Indre et Loire, 37000, France
CHU de Liège
RECRUITING

Liège, 4000, Belgium
CHU de Rennes
RECRUITING

Rennes, Cedex NA, 35033, France
CIC Mauricie
RECRUITING

Trois-Rivières, Quebec, G8T7A1, Canada
CIMER Centro Integral de Medicina Respiratoria
RECRUITING

San Miguel de Tucumán, Tucumán Province, 4000, Argentina
CINME
RECRUITING

Buenos Aires, Buenos Aires, C1056AB, Argentina
Canberra Hospital
RECRUITING

Canberra, 2605, Australia
Cedars-Sinai
RECRUITING

Los Angeles, California, 90048, United States
Centro Respiratorio Quilmes
RECRUITING

Quilmes, Buenos Aires, B1878, Argentina
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Clinica Monte Grande
RECRUITING

Monte Grande, Buenos Aires, 1842, Argentina
Clinical Site Partners
RECRUITING

Winter Park, Florida, 32789, United States
Clinical Site Partners, LCC
RECRUITING

Leesburg, Florida, 34748, United States
Clinical Trials Center of Middle Tennessee
RECRUITING

Franklin, Tennessee, 37067, United States
Columbia University
RECRUITING

New York, New York, 10032, United States
Cukurova University Medical Faculty
RECRUITING

Adana, 01240, Turkey (Türkiye)
Department of Pneumology of the University Hospital No 1
RECRUITING

Lodz, 90-153, Poland
Duke University
RECRUITING

Durham, North Carolina, 27710, United States
Dunedin Hospital
RECRUITING

Dunedin, Dunedine, 9016, New Zealand
Dynamic Drug Advancement
RECRUITING

Ajax, Ontario, L1S2J5, Canada
Ege University Medical Faculty Hospital
RECRUITING

Bornova, İzmir, 35100, Turkey (Türkiye)
El Paso Pulmonary Association
RECRUITING

El Paso, Texas, 79902, United States
Endeavor Health
RECRUITING

Evanston, Illinois, 60201, United States
Erasmus University Medical Center
RECRUITING

Rotterdam, 3015 GD, Netherlands
Fondazione IRCCS Policlinico San Matteo - UOC Pneumologia
RECRUITING

Pavia, Lombardy, 27100, Italy
Fundacion Respirar
RECRUITING

Buenos Aires, Buenos Aires, 1427, Argentina
Greenlane Clinical Centre
RECRUITING

Auckland, Auckland, 1051, New Zealand
HUMANITAS Research Hospital
RECRUITING

Rozzano, Milano, 20089, Italy
Hannibal Regional Healthcare System
RECRUITING

Hannibal, Missouri, 63401, United States
Health New Zealand
RECRUITING

Christchurch, Canterbury, 8011, New Zealand
Health Sciences University, Gulhane Faculty of Medicine
RECRUITING

Ankara, 06010, Turkey (Türkiye)
Hospital Gregorio Marañon
RECRUITING

Madrid, Madrid, 28007, Spain
Hospital Italiano de Buenos Aires
RECRUITING

Ciudad Autónoma de Buenos Aires, Buenos Aires, C1199ABH, Argentina
Hospital Universitario Central de Asturias
RECRUITING

Oviedo, Principality of Asturias, 33011, Spain
Hospital Universitario Marqués de Valdecilla
RECRUITING

Santander, Cantabria, 39008, Spain
Hospital Universitario Puerta del Mar - Leon-Jimenez
RECRUITING

Cadiz, 11009, Spain
Hospital Universitario Ramon y Cajal
RECRUITING

Madrid, Madrid, 28034, Spain
Hospital Universitario Virgen de la Victoria
RECRUITING

Málaga, Málaga, 29010, Spain
Hospital Universitario Virgen de las Nieves
RECRUITING

Granada, Andalusia, 18014, Spain
Hospital Universitario Virgen del Rocío
RECRUITING

Seville, Sevilla, 41013, Spain
Hospital Universitary de Bellvitge
RECRUITING

Barcelona, 08908, Spain
Hospital de Sant Pau y la Santa Creu
RECRUITING

Barcelona, Barcelona, 08025, Spain
Hull University Teaching Hospital NHS Trust
RECRUITING

Cottingham, East Yorkshire, HU16 5JQ, United Kingdom
Hôpital Haut-Lévêque
RECRUITING

Pessac, 33604, France
Hôpital Paris St Jozeph
RECRUITING

Paris, 75014, France
ILD Unit, University Hospitals Birmingham NHS Foundation Trust Theme
RECRUITING

Birmingham, Midlands, B15 2GW, United Kingdom
IRCCS AOU di Bologna - Policlinico Sant' Orsola
RECRUITING

Bologna, Emilia-Romagna, 40138, Italy
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Inova Healthcare
RECRUITING

Falls Church, Virginia, 22042, United States
Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval
RECRUITING

Québec, Quebec, G1V4G5, Canada
Institute for Respiratory Health
RECRUITING

Nedlands, Perth West Australia, 6009, Australia
Instituto Ave Pulmo, Fundacion Enfisema
RECRUITING

Mar del Plata, Buenos Aires, 7600, Argentina
Instituto de Medicina Respiratoria
RECRUITING

Córdoba, Córdoba Province, 5003, Argentina
Intermountain Medical Center
RECRUITING

Murray, Utah, 84157, United States
Investigaciones En Patologias Respiratorias
RECRUITING

San Miguel de Tucumán, Tucumán Province, 4000, Argentina
John Hunter Hospital
RECRUITING

New Lambton, New South Wales, 2305, Australia
Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21224, United States
Leicester Biomedical Research Centre - Respiratory Theme
RECRUITING

Glenfield, Leicester, LE3 9QP, United Kingdom
Louis Pradel Hospital
RECRUITING

Lyon, Lyon, 69677, France
Lowcountry Lung and Critical Care
RECRUITING

Charleston, South Carolina, 29406, United States
Loyola University Medical Center
RECRUITING

Maywood, Illinois, 60153, United States
Lung Research Victoria
RECRUITING

Footscray, Victoria, 3011, Australia
Macquarie University Clinical Trials Unit
RECRUITING

Sydney, New South Wales, 2109, Australia
Manchester University NHS Foundation Trust
RECRUITING

Manchester, M23 9LT, United Kingdom
Mayo Clinic Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic- Scottsdale
RECRUITING

Scottsdale, Arizona, 85259, United States

Contact Phone: •••-•••-••••

Contact
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Medizinische Hochschule Hannover
RECRUITING

Hanover, Lower Saxony, 30625, Germany
Metroplex Pulmonary and Sleep Center, PA
RECRUITING

McKinney, Texas, 75069, United States
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10467, United States
Muenchen Klinik Bogenhausen - Klinik für Pneumologie und Pneumologische Onkologie
RECRUITING

München, Bavaria, 81925, Germany
NYU Langone Health
RECRUITING

New York, New York, 10017, United States
National Jewish Health
RECRUITING

Denver, Colorado, 80206, United States
Nepean Lung & Sleep
RECRUITING

Kingswood, New South Wales, 2745, Australia
Newport Native MD, Inc.
RECRUITING

Newport Beach, California, 92663, United States
Northwell Health - Mount Kisco
RECRUITING

Mount Kisco, New York, 10549, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
Nottingham University NHS Trust
RECRUITING

Nottingham, NG5 1PB, United Kingdom
Ospedale San Giuseppe
RECRUITING

Milan, Milano, 20123, Italy
Oxford University Hospitals NHS Foundation Trust
RECRUITING

Oxford, Oxon, OX3 7LE, United Kingdom
PRYWATNY GABINET LEKARSKI GINEKOLOGIA I POŁOZNICTWO ULTRASONOGRAFIA Prof. Dr hab. Med. Jacek Suzin
RECRUITING

Lodz, 90-602, Poland
Paradigm Clinical Research - Redding
RECRUITING

Redding, California, 96001, United States
Piedmont HealthCare, PA
RECRUITING

Statesville, North Carolina, 28625, United States
Piedmont Healthcare, Inc.
RECRUITING

Atlanta, Georgia, 30309, United States
Pneumologisches Studienzentrum München-West
RECRUITING

Munich, Bavaria, 81241, Germany
Renstar Medical Research
RECRUITING

Ocala, Florida, 34470, United States
Research Institute McGill University Health Center
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
RoMed Klinikum Rosenheim
RECRUITING

Rosenheim, Bavaria, 83022, Germany
Robert Schuman Hospital UNEOS
RECRUITING

Metz, Lorraine, 57000, France
Royal Brompton Hospital
RECRUITING

London, SW3 6HP, United Kingdom
Royal Devon
RECRUITING

Exeter, South West, EX2 5DW, United Kingdom
Royal Papworth Hospital
RECRUITING

Cambridge, CB2 0BB, United Kingdom
Royal Prince Alfred Hospital
RECRUITING

Camperdown, New South Wales, 2050, Australia
Ruhrlandklinik Essen, Klinik fuer Pneumologie
RECRUITING

Essen, North Rhine-Westphalia, 45239, Germany
Southeastern Research Center
RECRUITING

Winston-Salem, North Carolina, 27103, United States
St Antoniusziekenhuis
RECRUITING

Nieuwegein, Utrecht, 3435, Netherlands
St George's University Hospitals NHS Foundation Trust
RECRUITING

London, London, sw17 0QT, United Kingdom
St James University Hospital - LTHT
RECRUITING

Leeds, West Yorkshire, LS9 7TF, United Kingdom
St. Joseph's Healthcare Hamilton
RECRUITING

Hamilton, Ontario, L8N 4A6, Canada
Studienzentrum Dr. Claus Keller
RECRUITING

Frankfurt, Main Hessia, 60389, Germany
Summit Health
RECRUITING

Bend, Oregon, 97701, United States
Temple University
RECRUITING

Philadelphia, Pennsylvania, 19140, United States
The Oregon Clinic Pulmonary East
RECRUITING

Portland, Oregon, 97220, United States
The Oregon Clinic Pulmonary West
RECRUITING

Portland, Oregon, 97225, United States
The Pennsylvania State University
RECRUITING

Hershey, Pennsylvania, 17033, United States
The Royal Wolverhampton NHS Trust, New Cross Hospital, Research and Development
RECRUITING

Wolverhampton, West Midlands, WV10 0QP, United Kingdom
The University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 66160, United States
The University of Texas Health Science Center
RECRUITING

Houston, Texas, 77030, United States
Thomas Jefferson University
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
UCLA
RECRUITING

Los Angeles, California, 90095, United States
UCONN Health
RECRUITING

Farmington, Connecticut, 06030, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States

Contact Phone: •••-•••-••••

Contact
UZ Leuven
RECRUITING

Leuven, 3000, Belgium
Uniklinikum Leipzig Medizinische Klinik II - Bereich
RECRUITING

Leipzig, Saxony, 04103, Germany
University Hospital in Krakow
RECRUITING

Krakow, Krakow, 30-688, Poland
University Hospitals of North Midlands NHS Trust, Royal Stoke University Hospital
RECRUITING

Stoke-on-Trent, ST4 6QG, United Kingdom
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35205, United States
University of California - San Francisco
RECRUITING

San Francisco, California, 94143, United States

Contact Phone: •••-•••-••••

Contact
University of Cincinnati
RECRUITING

Cincinnati, Ohio, 45267, United States
University of Colorado, Anschutz Medical Campus
RECRUITING

Aurora, Colorado, 80045, United States
University of Maryland
RECRUITING

Baltimore, Maryland, 21201, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55455, United States
University of Montpellier
RECRUITING

Montpellier, Montpellier, 34295, France
University of Southern California
RECRUITING

Los Angeles, California, 90033, United States
University of Utah Health
RECRUITING

Salt Lake City, Utah, 84108, United States
University of Washington
RECRUITING

Seattle, Washington, 98195, United States
Università degli Studi di Napoli Federico II - Ospedale Monaldi
RECRUITING

Naples, Campania, 80131, Italy
Universitätsmedizin Mainz - Zentrum für Thoraxerkrankungen
RECRUITING

Mainz, Rhineland-Palatinate, 55131, Germany
Vancouver General Hospital
RECRUITING

Vancouver, British Columbia, V5Z1M9, Canada
Vanderbilt Lung Institute
RECRUITING

Nashville, Tennessee, 37204, United States
Vitamed Galaj I Cichomski sp.j.
RECRUITING

Bydgoszcz, Bydgoszc, 85-079, Poland
Vivantes Klinikum Neukölln - Klinik für Innere Medizin - Pneumologie und Infektiologie
RECRUITING

Berlin, State of Berlin, 12351, Germany
Wallace Street Specialist Centre/Lung Research QLD Pty Ltd
RECRUITING

Brisbane, Queensland, 4032, Australia
Weill Cornell
RECRUITING

New York, New York, 10021, United States
Westmead Hospital
RECRUITING

Westmead, New South Wales, 2145, Australia
Yale University
RECRUITING

New Haven, Connecticut, 06519, United States

Conditions

Explore the condition pages connected to this study.

PROGRESSIVE PULMONARY FIBROSIS