Inhaled drug trial aims to clear stubborn lung bugs

NCT ID NCT06418711

Terminated Disease control Sponsor: Mannkind Corporation Source: ClinicalTrials.gov ↗

Summary

This study tested whether adding an inhaled antibiotic called clofazimine to standard treatment could help people with a persistent lung infection caused by nontuberculous mycobacteria (NTM). The main goals were to see if the inhaled drug could clear the bacteria from the lungs and improve breathing symptoms over six months. The trial was terminated and enrolled 132 adults who had not fully responded to standard antibiotic therapy.

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Contacts and locations

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Locations

Alfred Health

Melbourne, Victoria, 3004, Australia
AnMed Health

Anderson, South Carolina, 29621, United States
Asan Medical Center

Seoul, 05505, South Korea
Aso Iizuka Hospital

Fukuoka, 811-3195, Japan
Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States
Center Hospital of the National Center for Global Health and Medicine

Tokyo, 162-8655, Japan
Chonnam National University Hospital

Gwangju, 61469, South Korea
Cleveland Clinic

Weston, Florida, 33331, United States
Columbia University

New York, New York, 10032, United States
Concord Repatriation General Hospital

Concord, Australia
Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States
Emory University School Of Medicine

Atlanta, Georgia, 30342, United States
Flourish Research

Winter Park, Florida, 32789, United States
Fukuoka University Chikushi Hospital

Fukuoka, 818-8502, Japan
Fukuoka University Hospital

Fukuoka, 814-0180, Japan
Gallipoli Medical Research Foundation

Greenslopes, Queensland, 4064, Australia
Georgetown University Hospital

Washington D.C., District of Columbia, 20007, United States
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Himeji Medical Center

Hyōgo, 670-8520, Japan
Hoag Hospital

Newport Beach, California, 92663, United States
Ibarakihigashi National Hospital

Ibaraki, 319-1113, Japan
Infectious Disease Consultants Clinical Research

Wichita, Kansas, 67211, United States
Japan Anti-Tuberculosis Association Fukujuji Hospital

Tokyo, 204-8522, Japan
Japanese Red Cross Musashino Hospital

Tokyo, 180-8610, Japan
Johns Hopkins University School of Medicine

Baltimore, Maryland, 21287, United States
Kameda Clinic

Kamogawa-shi, 296-0041, Japan
Kaohsiung Medical University Hospital

Kaohsiung City, 807, Taiwan
Keio University Hospital

Shinjuku-ku, 160-8582, Japan
Low Country Infectious Diseases

Charleston, South Carolina, 29414, United States
Macquarie University Clinical Trials Unit

Sydney, New South Wales, 2109, Australia
Malcolm Randall Veterans Affairs Medical Center

Gainesville, Florida, 32608, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Matsusaka Municipal Hospital

Matsusaka, 515-8544, Japan
Mayo Clinic

Rochester, Minnesota, 55905, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Medster Research

Valdosta, Georgia, 31605, United States
Midway Specialty Care Center

West Palm Beach, Florida, 33401, United States
Minami Kyoto Hospital

Kyoto, 610-0113, Japan
Monash University Centre for Inflammatory Diseases

Cranbourne, Victoria, 3977, Australia
Montefiore Medical Center

The Bronx, New York, 10467, United States
Mount Sinai-National Jewish Respiratory Institute

New York, New York, 10029, United States
Mutual Aid Associations Toranomon Hospital

Tokyo, 105-8470, Japan
NYC Health and Hospitals-Elmhurst

Queens, New York, 11373, United States
NYU Langone Health

New York, New York, 10016, United States
National Hospital Organization - Osaka Toneyama Medical Center

Osaka, 560-8552, Japan
National Hospital Organization Fukuokahigashi Medical Center

Fukuoka, 811-3195, Japan
National Hospital Organization Kinki-Chuo Chest Medical Center

Sakai, 591-8555, Japan
National Hospital Organization Omuta National Hospital

Fukuoka, 837-0911, Japan
National Hospital Organization Shibukawa Medical Center

Gunma, 377-0280, Japan
National Hospital Organization Tenryu Hospital

Shizuoka, 434-8511, Japan
National Jewish Health

Denver, Colorado, 80206, United States
National Taiwan University Hospital

Hsinchu, 300, Taiwan
National Taiwan University Hospital

Taipei, Taiwan
Nishiniigata Chuo Hospital

Niigata, 945-8585, Japan
North Texas Infectious Diseases Consultants

Dallas, Texas, 75246, United States
Northwell Health

New Hyde Park, New York, 11042, United States
Ochsner Clinic Foundation

New Orleans, Louisiana, 70115, United States
Oregon Health & Science University

Portland, Oregon, 97239, United States
Reading Hospital

West Reading, Pennsylvania, 19611, United States
Royal Adelaide Hospital

Adelaide, 5000, Australia
Royal Perth Hospital Respiratory Clinic

Perth, Western Australia, 6000, Australia
Rutgers New Jersey Medical School

Newark, New Jersey, 07103, United States
SHOWA University Fujigaoka Hospital

Kanagawa, 227-8501, Japan
SHOWA University Northern Yokohama Hospital

Yokohama, 224-8503, Japan
Saitama Prefectural Cardiovascular and Respiratory Center

Saitama, 180-8610, Japan
Samsung Medical Center

Seoul, 06351, South Korea
Santa Barbara Cottage Hospital

Santa Barbara, California, 93105, United States
Sendai Kousei Hospital

Miyagi, 980-0873, Japan
Seoul National University Hospital

Seoul, 03080, South Korea
Severance Hospital

Seoul, 03722, South Korea
St. Francis Sleep, Allergy & Lung Institute

Clearwater, Florida, 33765, United States
Stanford University

Stanford, California, 94305, United States
Sunshine Coast University Hospital

Birtinya, Queensland, 4575, Australia
Taichung Veterans General Hospital

Taichung, 407219, Taiwan
Taipei Veterans General Hospital

Taipei, 112, Taiwan
Temple Lung Center

Philadelphia, Pennsylvania, 19140, United States
The Catholic University of Korea Seoul St.Mary's Hospital

Seoul, 06591, South Korea
The George Washington University Medical Faculty Associates

Washington D.C., District of Columbia, 20037, United States
The Prince Charles Hospital

Brisbane, Queensland, 4032, Australia
The University of Texas Health Science Center

Tyler, Texas, 75708, United States
Theia Clinical Research

St. Petersburg, Florida, 33707, United States
Toho University Omori Medical Center

Tokyo, 143-8541, Japan
UCONN Health

Farmington, Connecticut, 06030-1225, United States
UVA Health Infectious Diseases Clinic

Charlottesville, Virginia, 22903, United States
University of Alabama at Birmingham School of Medicine

Birmingham, Alabama, 35294, United States
University of California Davis Medical Center

Sacramento, California, 95817, United States
University of California San Francisco

San Francisco, California, 94143, United States
University of California San Francisco Fresno

Fresno, California, 93701, United States
University of Florida College of Medicine

Jacksonville, Florida, 32209, United States
University of Hawaii

Honolulu, Hawaii, 96813, United States
University of Iowa Hospital and Clinics

Iowa City, Iowa, 52242, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of Missouri

Columbia, Missouri, 65201, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States
University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27599-7248, United States
University of South Florida

Tampa, Florida, 33620, United States
VA Bay Pines

Bay Pines, Florida, 33744, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Yale University

New Haven, Connecticut, 06520-8057, United States

Conditions

Explore the condition pages connected to this study.

MAC LUNG DISEASE MYCOBACTERIUM INFECTIONS, NONTUBERCULOUS TREATMENT REFRACTORY MAC LUNG DISEASE