New bone graft could improve spine surgery outcomes
NCT ID NCT03118505
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether a special bone graft (Infuse Bone Graft with Mastergraft Strip) helps fuse multiple spine bones better than a standard graft in people with degenerative lower back conditions. About 100 adults will be randomly assigned to receive either the new graft or a standard one during surgery. The main goal is to see if the new graft leads to successful bone fusion and improved pain and function.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Infuse Bone Graft (contains rhBMP-2 protein to stimulate bone growth)
What this could lead to
If successful, this could lead to a more effective way to fuse multiple spine levels, potentially reducing pain and disability for people with degenerative spinal conditions.
What could go wrong
This is an early pilot study with only 100 participants, so results may not apply to everyone. The treatment involves surgery and carries risks like infection, nerve damage, or bone overgrowth.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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American Neurospine Institute PLLC
Plano, Texas, 75075, United States
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Bronson Methodist Hospital
Kalamazoo, Michigan, 49007, United States
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Emory University
Atlanta, Georgia, 30329, United States
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Fort Wayne Orthopedics
Fort Wayne, Indiana, 46804, United States
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Foundation for Orthopedic Research and Education
Tampa, Florida, 33637, United States
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Indiana Spine Group
Carmel, Indiana, 46032, United States
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New York-Presbyterian Hospital/Columbia University
New York, New York, 10034, United States
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Seton Spine & Scoliosis Center
Austin, Texas, 78731, United States
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Spine Colorado
Durango, Colorado, 81301, United States
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The Ohio State University Wexner Medical Center
Columbus, Ohio, 43210, United States
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The Spine Health Institute
Altamonte Springs, Florida, 32701, United States
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The Steadman Clinic
Vail, Colorado, 81657, United States
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The University of Kansas (KUMC)
Kansas City, Kansas, 66160, United States
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University of California, Davis
Sacramento, California, 95816, United States
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University of Virginia
Charlottesville, Virginia, 22903, United States
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University of Virginia Health System
Charlottesville, Virginia, 22903, United States
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Upstate Orthopedics
East Syracuse, New York, 13057, United States