Global registry tracks safety of growth drug in kids

NCT ID NCT00903110

Recruiting now Knowledge-focused Sponsor: Esteve Pharmaceuticals, S.A. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This global registry follows 500 children and teens with severe primary IGF-1 deficiency who are taking or will take Increlex® (mecasermin). The goal is to monitor long-term safety and side effects over at least 5 years after treatment ends. It is an observational study, meaning no new drug is being tested—just real-world data collection.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mecasermin (Increlex®)
What this could lead to: If successful, this registry will provide crucial safety data on long-term use of Increlex® in children, helping doctors better manage treatment.
What could go wrong: This is an observational registry, not a controlled trial, so it cannot prove cause and effect. Results depend on real-world reporting and may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

growth delay due to insulin-like growth factor type 1 deficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IGF1 DEFICIENCY

Contacts and locations

Locations

Azienda Ospedaliera Universitaria II
NOT_YET_RECRUITING

Naples, 80138, Italy
Azienda Ospedaliera-Universitaria di Parma
NOT_YET_RECRUITING

Parma, Italy
Azienda USL-IRCCS
RECRUITING

Reggio Emilia, Italy
Azienda ospedaliera universitaria Meyer
NOT_YET_RECRUITING

Florence, 50139, Italy
Birmingham Children's Hospital
TERMINATED

Birmingham, B4 6NH, United Kingdom
CHU Lenval
WITHDRAWN

Nice, 06200, France
Centre Hospitalier de Blois
RECRUITING

Blois, 41000, France
Children's Health Specialty Center West Plano
WITHDRAWN

Plano, Texas, 75093, United States
Children's Hospital of Orange County
RECRUITING

Orange, California, 92868, United States
Cincinnati Children's Hospital Medical Center
RECRUITING

Cincinnati, Ohio, 45229, United States
D&H National Research Centers
WITHDRAWN

Miami, Florida, 33155, United States
Diabetologia Pediatrica Azienda Ospedaliero-Universitaria
NOT_YET_RECRUITING

Ancona, Italy
GHR Mulhouse Sud-Alsace
TERMINATED

Mulhouse, France
Great Ormond Street Hospital
RECRUITING

London, WC1N 3JH, United Kingdom
Hospital Parc Taulí de Sabadell
RECRUITING

Barcelona, 08208, Spain
Hospital Sant Joan de Déu
RECRUITING

Barcelona, 08950, Spain
Hospital Univ Vall d'Hebrón
TERMINATED

Barcelona, 08035, Spain
Hospital Univ. de Cruces
RECRUITING

Bilbao, 48903, Spain
Hospital Universitari Sant Joan de Reus
RECRUITING

Reus, 43204, Spain
Hospital Universitario y Politécnico La Fe
RECRUITING

Valencia, 46026, Spain
Hôpital Amiens-Picardie
TERMINATED

Amiens, 80080, France
Hôpital Arnaud de Villeneuve
RECRUITING

Montpellier, 34090, France
Hôpital Estaing
RECRUITING

Clermont-Ferrand, 63100, France
Hôpital Femme Mère-Enfant
RECRUITING

Bron, 69500, France
Hôpital Jean Verdier
RECRUITING

Bondy, 93140, France
Hôpital Kremlin Bicetre
RECRUITING

Paris, 97270, France
Hôpital Necker Enfants Malades
RECRUITING

Paris, 75015, France
Hôpital Pierre Zobda Quitman
RECRUITING

Fort-de-France, 97200, Martinique
Hôpital Timone Enfants
RECRUITING

Marseille, 13005, France
Hôpital de Cayenne
WITHDRAWN

Cayenne, 97306, French Guiana
Hôpital des Enfants
RECRUITING

Toulouse, 31300, France
I.R.C.C.S. Giannina Gaslini
RECRUITING

Genova, 16147, Italy
Karolinska Universitetssjukhuset
RECRUITING

Stockholm, 17176, Sweden
Kliniczny Szpital Wojewódzki
RECRUITING

Rzeszów, 35-301, Poland
Klinikum Oldenburg
TERMINATED

Oldenburg, 26133, Germany
Klinikum der Otto von Guericke Universität
TERMINATED

Magdeburg, 39120, Germany
Leeds General Infirmary
RECRUITING

Leeds, LS1 3EX, United Kingdom
Linköping University Hospital
RECRUITING

Linköping, 57850, Sweden
Ospedale Pediatrico Bambino Gesù
RECRUITING

Roma, 00165, Italy
Ospedale di Bolzano
RECRUITING

Bolzano, 39100, Italy
Pole medical Bel'Air
RECRUITING

Mulhouse, France
Pomeranian Medical University
RECRUITING

Szczecin, Poland
Royal Belfast Hospital for Sick Children
RECRUITING

Belfast, BT12 6BA, United Kingdom
Royal Manchester Children's Hospital
TERMINATED

Manchester, M13 0JH, United Kingdom
Salzkammergut-Klinik Vöcklabruck
RECRUITING

Vöcklabruck, A-4840, Austria
Samodzielny Publiczny Dzieciecy Szpital Kliniczny
RECRUITING

Bialystok, 15-274, Poland
Spedali Civili di Brescia
TERMINATED

Brescia, 25100, Italy
Szpital kliniczny im. Karola Jonschnera
RECRUITING

Poznan, 60-572, Poland
The Royal London Hospital
RECRUITING

London, E1 1FR, United Kingdom
U.O. Pediatria e Neonatologia Ospedale di Macerata
TERMINATED

Province of Macerata, Italy
UT Southwestern Medical Center
NOT_YET_RECRUITING

Dallas, Texas, 75390, United States
University Of Miami Leonard M. Miller
RECRUITING

Miami, Florida, 33136, United States
University of Miami Leonard M Miller
RECRUITING

Miami, Florida, 33136, United States
Universitätskliniken des Saarlandes Kinderklinik
RECRUITING

Homburg, 66424, Germany
Universitätsklinikum Erlangen Kinder- und Jugendklinik
RECRUITING

Erlangen, 91054, Germany
Universitätsklinikum Heidelberg Kinderheilkunde
RECRUITING

Heidelberg, 69120, Germany
Uniwersytecki Szpital Dziecięcy w Lublinie
RECRUITING

Lublin, 20-093, Poland
Uniwersyteckie Centrum Kliniczne
RECRUITING

Gdansk, 80-294, Poland