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Major trial pits new immune drugs against standard chemo for lung cancer

NCT ID NCT02477826

Completed Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

Summary

This large, completed Phase 3 trial tested whether immunotherapy drugs (nivolumab with or without ipilimumab), alone or combined with chemotherapy, worked better than standard chemotherapy for people with advanced lung cancer who hadn't had prior treatment. It aimed to see if these newer treatments could help patients live longer or keep the cancer from growing. The study involved over 2,700 participants with stage IV or recurrent non-small cell lung cancer.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Azienda Ospedaliera Moscati

    Avellino, 83024, Italy

  • Fondazione IRCCS Istituto Nazionale dei Tumori

    Milan, 20133, Italy

  • IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola

    Bologna, 40138, Italy

  • Ifo-Istituto Regina Elena

    Roma, 00144, Italy

  • Istituto Nazionale Tumori Fondazione Pascale

    Naples, 80131, Italy

  • Local Institution - 0001

    Atlanta, Georgia, 30322, United States

  • Local Institution - 0003

    Dallas, Texas, 75390, United States

  • Local Institution - 0004

    Lexington, Kentucky, 40503, United States

  • Local Institution - 0005

    Buffalo, New York, 14263, United States

  • Local Institution - 0007

    Allentown, Pennsylvania, 18103, United States

  • Local Institution - 0008

    Charleston, South Carolina, 29425, United States

  • Local Institution - 0009

    Columbus, Ohio, 43210, United States

  • Local Institution - 0010

    Greenville, South Carolina, 29607, United States

  • Local Institution - 0011

    Salt Lake City, Utah, 84108, United States

  • Local Institution - 0012

    Philadelphia, Pennsylvania, 19111-2412, United States

  • Local Institution - 0013

    Marietta, Georgia, 30060, United States

  • Local Institution - 0014

    Cleveland, Ohio, 44106, United States

  • Local Institution - 0015

    Sayre, Pennsylvania, 18840, United States

  • Local Institution - 0017

    San Francisco, California, 94115, United States

  • Local Institution - 0019

    New York, New York, 10065, United States

  • Local Institution - 0020

    Nashville, Tennessee, 37232, United States

  • Local Institution - 0021

    New Haven, Connecticut, 06520, United States

  • Local Institution - 0022

    Moscow, 115478, Russia

  • Local Institution - 0024

    Budapest, 1121, Hungary

  • Local Institution - 0025

    Budapest, 1083, Hungary

  • Local Institution - 0026

    Mátraháza, 3233, Hungary

  • Local Institution - 0027

    Saint Petersburg, 198255, Russia

  • Local Institution - 0028

    Saint Petersburg, 194291, Russia

  • Local Institution - 0030

    Edegem, 2650, Belgium

  • Local Institution - 0031

    Ghent, 9000, Belgium

  • Local Institution - 0033

    Sint-Niklaas, 9100, Belgium

  • Local Institution - 0034

    Charleroi, Hainaut, 6060, Belgium

  • Local Institution - 0036

    Amsterdam, 1066 CX, Netherlands

  • Local Institution - 0037

    Rotterdam, 3014 GD, Netherlands

  • Local Institution - 0039

    Veldhoven, 5504 DB, Netherlands

  • Local Institution - 0040

    Murdoch, 6150, Australia

  • Local Institution - 0042

    Fitzroy, Victoria, 3065, Australia

  • Local Institution - 0043

    Clayton, Victoria, 3168, Australia

  • Local Institution - 0045

    Brisbane, Queensland, 4102, Australia

  • Local Institution - 0046

    Elizabeth Vale, South Australia, 5112, Australia

  • Local Institution - 0049

    Saint Petersburg, 197758, Russia

  • Local Institution - 0050

    London, SE1 9RT, United Kingdom

  • Local Institution - 0051

    Cambridgeshire, CB2 2QQ, United Kingdom

  • Local Institution - 0053

    Beaumont, Dublin 9, Ireland

  • Local Institution - 0054

    Dublin, Dublin, Ireland

  • Local Institution - 0055

    Galway, 0, Ireland

  • Local Institution - 0057

    Lodz, 93-513, Poland

  • Local Institution - 0058

    Gdansk, 80-19, Poland

  • Local Institution - 0059

    Warsaw, 02-781, Poland

  • Local Institution - 0060

    Bydgoszcz, 85-796, Poland

  • Local Institution - 0063

    Gdynia, 81-519, Poland

  • Local Institution - 0064

    Majadahonda, Madrid, 28222, Spain

  • Local Institution - 0065

    Madrid, 28041, Spain

  • Local Institution - 0066

    Barcelona, 08035, Spain

  • Local Institution - 0067

    Barcelona, 08916, Spain

  • Local Institution - 0068

    Valencia, 46014, Spain

  • Local Institution - 0069

    Seville, 41013, Spain

  • Local Institution - 0070

    Wroclaw, 52-229, Poland

  • Local Institution - 0072

    Gliwice, 44-101, Poland

  • Local Institution - 0074

    Kennewick, Washington, 99336, United States

  • Local Institution - 0075

    Langhorne, Pennsylvania, 19047, United States

  • Local Institution - 0080

    Greenville, South Carolina, 29605, United States

  • Local Institution - 0083

    Milan, Lombardy, 20141, Italy

  • Local Institution - 0084

    Livorno, 57124, Italy

  • Local Institution - 0085

    Terni, 05100, Italy

  • Local Institution - 0087

    Perugia, 06132, Italy

  • Local Institution - 0089

    Roma, 00161, Italy

  • Local Institution - 0094

    Athens, Attikí, 115 27, Greece

  • Local Institution - 0095

    Heraklion, 711 10, Greece

  • Local Institution - 0097

    London, N18 1QX, United Kingdom

  • Local Institution - 0098

    London, Greater London, SW3 6JJ, United Kingdom

  • Local Institution - 0099

    Southampton, Hampshire, SO16 0YD, United Kingdom

  • Local Institution - 0100

    Limerick, 0, Ireland

  • Local Institution - 0101

    Thessaloniki, 54007, Greece

  • Local Institution - 0102

    Houston, Texas, 77030, United States

  • Local Institution - 0103

    Edmonton, Alberta, T6G 1Z2, Canada

  • Local Institution - 0104

    London, Ontario, N6A 5W9, Canada

  • Local Institution - 0106

    Québec, Quebec, G1J 1Z4, Canada

  • Local Institution - 0107

    Rimouski, Quebec, G5L 5T1, Canada

  • Local Institution - 0109

    Edinburgh, EH4 2XU, United Kingdom

  • Local Institution - 0111

    Prague, 140 59, Czechia

  • Local Institution - 0112

    Hradec Králové, 500 05, Czechia

  • Local Institution - 0113

    Olomouc, 779 00, Czechia

  • Local Institution - 0115

    St Louis, Missouri, 63110, United States

  • Local Institution - 0117

    Hasselt, 3500, Belgium

  • Local Institution - 0118

    Leicester, Leicestershire, LE1 5WW, United Kingdom

  • Local Institution - 0119

    Surrey, SM2 5PT, United Kingdom

  • Local Institution - 0121

    Roeselare, West-Vlaanderen, 8800, Belgium

  • Local Institution - 0122

    Montreal, Quebec, H3T 1E2, Canada

  • Local Institution - 0123

    Porto Alegre, Rio Grande do Sul, 90610-000, Brazil

  • Local Institution - 0124

    Ijuí, Rio Grande do Sul, 98700-000, Brazil

  • Local Institution - 0125

    Salvador, Estado de Bahia, 40170-110, Brazil

  • Local Institution - 0126

    São Paulo, 01509-010, Brazil

  • Local Institution - 0127

    Barretos, São Paulo, 14784-400, Brazil

  • Local Institution - 0128

    São Paulo, 05403-010, Brazil

  • Local Institution - 0129

    Rio de Janeiro, 20231-050, Brazil

  • Local Institution - 0130

    San Miguel de Tucumán, Tucumán Province, 4000, Argentina

  • Local Institution - 0131

    Santiago, Santiago Metropolitan, 8420383, Chile

  • Local Institution - 0132

    Seoul, 05505, South Korea

  • Local Institution - 0133

    Gangnam-gu, 06351, South Korea

  • Local Institution - 0135

    Seoul, 06591, South Korea

  • Local Institution - 0136

    Seongnam-si, Kyǒnggi-do, 436-707, South Korea

  • Local Institution - 0137

    Chelyabinsk, 454048, Russia

  • Local Institution - 0138

    Taipei, 100, Taiwan

  • Local Institution - 0139

    Taichung, 407, Taiwan

  • Local Institution - 0140

    Taipei, 112, Taiwan

  • Local Institution - 0141

    Taoyuan, 333, Taiwan

  • Local Institution - 0142

    Kazan', 420029, Russia

  • Local Institution - 0143

    Ufa, 450054, Russia

  • Local Institution - 0144

    São Paulo, 01321-001, Brazil

  • Local Institution - 0145

    Sendai, Miyagi, 9808574, Japan

  • Local Institution - 0146

    Kanazawa, Ishikawa-ken, 9208641, Japan

  • Local Institution - 0147

    Chuo-ku, Tokyo, 1040045, Japan

  • Local Institution - 0148

    Kashiwa-shi, Chiba, 2778577, Japan

  • Local Institution - 0149

    Koto-ku, Tokyo, 1358550, Japan

  • Local Institution - 0150

    Yokohama, Kanagawa, 2360051, Japan

  • Local Institution - 0151

    Sunto-gun, Shizuoka, 4118777, Japan

  • Local Institution - 0152

    Nagoya, Aichi-ken, 4648681, Japan

  • Local Institution - 0153

    Nagoya, Aichi-ken, 4600001, Japan

  • Local Institution - 0154

    Osaka, Osaka, 5340021, Japan

  • Local Institution - 0155

    Hirakata-shi, Osaka, 5731191, Japan

  • Local Institution - 0156

    Kobe, Hyōgo, 6500047, Japan

  • Local Institution - 0157

    Wakayama, Wakayama, 641-8510, Japan

  • Local Institution - 0158

    Kurashiki-shi, Okayama-ken, 7100052, Japan

  • Local Institution - 0159

    Matsuyama, Ehime, 791-0280, Japan

  • Local Institution - 0160

    Fukuoka, Fukuoka, 8120054, Japan

  • Local Institution - 0161

    Yokohama, Kanagawa, 2210855, Japan

  • Local Institution - 0162

    Tokyo, 113-8603, Japan

  • Local Institution - 0163

    Sapporo, Hokkaido, 0030804, Japan

  • Local Institution - 0164

    Niigata, Niigata, 9518566, Japan

  • Local Institution - 0165

    Okayama, 700-8558, Japan

  • Local Institution - 0166

    Romania, 400015, Romania

  • Local Institution - 0167

    Craiova, 200542, Romania

  • Local Institution - 0169

    Breda, 4818 CK, Netherlands

  • Local Institution - 0170

    Berazategui, Buenos Aires, 1880, Argentina

  • Local Institution - 0171

    Capital Federal, Buenos Aires, 1426, Argentina

  • Local Institution - 0172

    Ciudad Autonoma de Buenos Aire, Buenos Aires, 1181, Argentina

  • Local Institution - 0173

    Santiago, Santiago Metropolitan, 7500921, Chile

  • Local Institution - 0174

    Viña del Mar, Región de Valparaíso, 254 0364, Chile

  • Local Institution - 0176

    Ciudad de Buenos Aires, Buenos Aires, 1025, Argentina

  • Local Institution - 0177

    Viedma, 8500, Argentina

  • Local Institution - 0179

    Bergamo, 24127, Italy

  • Local Institution - 0180

    Perth, Western Australia, 6150, Australia

  • Local Institution - 0182

    Garran, Australian Capital Territory, 2605, Australia

  • Local Institution - 0183

    North Tamworth, 2340, Australia

  • Local Institution - 0184

    Tel Litwinsky, 52621, Israel

  • Local Institution - 0185

    Petah Tikva, 49100, Israel

  • Local Institution - 0186

    Kfar Saba, 44281, Israel

  • Local Institution - 0187

    Jerusalem, 91120, Israel

  • Local Institution - 0188

    Ẕerifin, 70300, Israel

  • Local Institution - 0189

    Amsterdam, 1081 HV, Netherlands

  • Local Institution - 0190

    Neo Faliro, 18547, Greece

  • Local Institution - 0191

    Zapopan, Jalisco, 44280, Mexico

  • Local Institution - 0192

    Chihuahua City, 31217, Mexico

  • Local Institution - 0193

    Mexico City, Mexico City, 14080, Mexico

  • Local Institution - 0194

    Toluca, 50180, Mexico

  • Local Institution - 0195

    San Luis Potosí City, 78200, Mexico

  • Local Institution - 0196

    Df, Mexico City, 06720, Mexico

  • Local Institution - 0197

    Guadalajara, Jalisco, 44270, Mexico

  • Local Institution - 0198

    Cuautitlán, State of Mexico, 54769, Mexico

  • Local Institution - 0201

    Stuttgart, 70376, Germany

  • Local Institution - 0202

    Heidelberg, 69126, Germany

  • Local Institution - 0203

    Großhansdorf, 22927, Germany

  • Local Institution - 0204

    München, 81925, Germany

  • Local Institution - 0205

    Essen, 45147, Germany

  • Local Institution - 0206

    Immenstadt im Allgäu, 87509, Germany

  • Local Institution - 0208

    Berlin, 13125, Germany

  • Local Institution - 0209

    Halle, 06120, Germany

  • Local Institution - 0210

    Frankfurt, 60590, Germany

  • Local Institution - 0211

    Gera, 07548, Germany

  • Local Institution - 0212

    Wiesbaden, 65199, Germany

  • Local Institution - 0213

    Bad Berka, 99437, Germany

  • Local Institution - 0214

    Hemer, 58675, Germany

  • Local Institution - 0215

    Marseille, 13915, France

  • Local Institution - 0216

    Angers, 49055, France

  • Local Institution - 0217

    Saint-Herblain, 44805, France

  • Local Institution - 0218

    Créteil, 94010, France

  • Local Institution - 0221

    Saint-Priest-en-Jarez, 42271, France

  • Local Institution - 0222

    Bron, Rhône, 69677, France

  • Local Institution - 0223

    Rennes, 350330, France

  • Local Institution - 0224

    Strasbourg, 67000, France

  • Local Institution - 0225

    Rouen, 76000, France

  • Local Institution - 0226

    Toulon, 83056, France

  • Local Institution - 0227

    Pessac, 33604, France

  • Local Institution - 0228

    Limoges, 87042, France

  • Local Institution - 0229

    Besançon, 0, France

  • Local Institution - 0230

    Paris, 75018, France

  • Local Institution - 0231

    Magdeburg, Saxony-Anhalt, 39120, Germany

  • Local Institution - 0232

    Příbram, 261 01, Czechia

  • Local Institution - 0233

    Saxonwold, Johannesburg, Gauteng, 2196, South Africa

  • Local Institution - 0234

    Sandton, Gauteng, 2196, South Africa

  • Local Institution - 0236

    San Luis Potosí City, 78213, Mexico

  • Local Institution - 0237

    Bogotá, 0, Colombia

  • Local Institution - 0238

    Bogotá, 0, Colombia

  • Local Institution - 0239

    Wels, 4600, Austria

  • Local Institution - 0240

    Vienna, 1090, Austria

  • Local Institution - 0241

    Graz, 8036, Austria

  • Local Institution - 0243

    Basel, 4031, Switzerland

  • Local Institution - 0244

    Lausanne, 1011, Switzerland

  • Local Institution - 0245

    Winterthur, 8401, Switzerland

  • Local Institution - 0246

    Chur, 7000, Switzerland

  • Local Institution - 0249

    Cheongju-si, 28644, South Korea

  • Local Institution - 0250

    Floreşti, 407280, Romania

  • Local Institution - 0251

    Osakasayama-shi, Osaka, 5890014, Japan

  • Local Institution - 0252

    Akashi-shi, Hyōgo, 6738558, Japan

  • Local Institution - 0253

    Sapporo, Hokkaido, 0608648, Japan

  • Local Institution - 0254

    Sendai, Miyagi, 9800873, Japan

  • Local Institution - 0255

    Ota-shi, Gunma, 3730828, Japan

  • Local Institution - 0256

    Kitaadachi-gun, Saitama, 3620806, Japan

  • Local Institution - 0257

    Takatsuki-shi, Osaka, 5698686, Japan

  • Local Institution - 0258

    Hiroshima, Hiroshima, 7308518, Japan

  • Local Institution - 0259

    Kurume-shi, Fukuoka, 8300011, Japan

  • Local Institution - 0260

    Chiba, Chiba, 260-8677, Japan

  • Local Institution - 0261

    Lima, 34, Peru

  • Local Institution - 0262

    Lima, 0, Peru

  • Local Institution - 0263

    Lima, 0, Peru

  • Local Institution - 0264

    Pretoria, Gauteng, 0002, South Africa

  • Local Institution - 0265

    Birmingham, B4 6DHH, United Kingdom

  • Local Institution - 0266

    Middlesbrough, Cleveland, TS4 3BW, United Kingdom

  • Local Institution - 0267

    Morelia, Michoacán, 58000, Mexico

  • Local Institution - 0268

    Córdoba, 5000, Argentina

  • Local Institution - 0270

    Oulu, 90029, Finland

  • Local Institution - 0271

    Turku, 20520, Finland

  • Local Institution - 0272

    Córdoba, 5016, Argentina

  • Local Institution - 0273

    Pereira, Risaralda Department, 0, Colombia

  • Local Institution - 0275

    Natori-shi, Miyagi, 9811293, Japan

  • Local Institution - 0277

    Monterrey, Nuevo León, 64060, Mexico

  • Local Institution - 0278

    Shinjuku-ku, Tokyo, 1600023, Japan

  • Local Institution - 0282

    Medellín, 050034, Colombia

  • Local Institution - 0283

    Caen, 14076, France

  • Local Institution - 0284

    Sector 2, 022328, Romania

  • Local Institution - 0286

    Beirut, 166830, Lebanon

  • Local Institution - 0287

    Beirut, 00961, Lebanon

  • Local Institution - 0290

    St. John's, Newfoundland and Labrador, A1B 3V6, Canada

  • Local Institution - 0291

    Sherbrooke, Quebec, J1H 5N4, Canada

  • Local Institution - 0292

    Trois-Rivières, Quebec, G8Z 3R9, Canada

  • Local Institution - 0296

    Mar del Plata, Buenos Aires, 7600, Argentina

  • Local Institution - 0297

    Córdoba, X50004FHP, Argentina

  • Local Institution - 0299

    Philadelphia, Pennsylvania, 19107, United States

  • Local Institution - 0300

    Gosford, New South Wales, 2250, Australia

  • Local Institution - 0301

    Blacktown, New South Wales, 2148, Australia

  • Local Institution - 0302

    Québec, Quebec, G1V 4G5, Canada

  • Local Institution - 0303

    Mérida, Yucatán, 97070, Mexico

  • Local Institution - 0305

    Vereeniging, 1936, South Africa

  • Local Institution - 0306

    Dallas, Texas, 75390-8852, United States

  • Local Institution - 0310

    Taipei, 235, Taiwan

  • Local Institution - 0313

    Beijing, Beijing Municipality, 100001, China

  • Local Institution - 0314

    Beijing, Beijing Municipality, 100032, China

  • Local Institution - 0315

    Beijing, Beijing Municipality, 100021, China

  • Local Institution - 0316

    Beijing, Beijing Municipality, 100021, China

  • Local Institution - 0319

    Guanzhou, Guangdong, 510080, China

  • Local Institution - 0322

    Guangzhou, Guangdong, 510060, China

  • Local Institution - 0323

    Haikou, Hainan, 570311, China

  • Local Institution - 0324

    Zhengzhou, Henan, 0, China

  • Local Institution - 0325

    Haerbin, Heilongjiang, 150081, China

  • Local Institution - 0328

    Changsha, 0, China

  • Local Institution - 0329

    Changchun, Jilin, 130012, China

  • Local Institution - 0333

    Xi'an, Shan3xi, 710038, China

  • Local Institution - 0334

    Shanghai, Shanghai Municipality, 200032, China

  • Local Institution - 0336

    Shanghai, Shanghai Municipality, 200030, China

  • Local Institution - 0337

    Shanghai, 200030, China

  • Local Institution - 0340

    Ürümqi, Xinjiang, 830011, China

  • Local Institution - 0341

    Hangzhou, 310016, China

  • Local Institution - 0342

    Hangzhou, Zhejiang, 310022, China

  • Local Institution - 0343

    Hangzhou, Zhejiang, 310003, China

  • Local Institution - 0345

    Kunming, 0, China

  • Local Institution - 0347

    Nanchang, Jiangxi, 0, China

  • Local Institution - 0350

    Lima, 27, Peru

  • Local Institution - 0351

    Lima, Lima 41, Peru

  • Local Institution - 0353

    Hidaka-shi, Saitama, 3501298, Japan

  • Local Institution - 0354

    Ube-shi, Yamaguchi, 7550241, Japan

  • Local Institution - 0359

    Shenyang, Liaoning, 110000, China

  • Local Institution - 0360

    Qingdao, Shandong, 266061, China

  • Local Institution - 0361

    Changchun, Jilin, 130021, China

  • Local Institution - 0362

    Changsha, Hunan, 410013, China

  • Local Institution - 0364

    Chongqing, Chongqing Municipality, 400038, China

  • Local Institution - 0365

    Chongqing, Chongqing Municipality, 400037, China

  • Local Institution - 0370

    Hangzhou, Zhejiang, 310009, China

  • Local Institution - 0371

    Xi'an, Shaanxi, 710061, China

  • Local Institution - 0372

    Guangzhou, Guangdong, 510095, China

  • Local Institution - 0373

    Tianjin, Tianjin Municipality, 300060, China

  • Local Institution - 0374

    Shantou, 0, China

  • Local Institution - 0375

    Wuhan, Hubei, 430024, China

  • Local Institution - 0376

    Chengdu, Sichuan, 610041, China

  • Local Institution - 0378

    Chongqing, Chongqing Municipality, 400042, China

  • Local Institution - 0379

    Zhengzhou, Henan, 450052, China

  • Local Institution - 0380

    Hefei, Anhui, 230001, China

  • Ospedale Santa Maria delle Croci

    Ravenna, 48121, Italy

  • Policlinico G. Martino

    Messina, 98125, Italy

  • Southern Cancer Center, Inc.

    Mobile, Alabama, 36608, United States

Conditions

Explore the condition pages connected to this study.

NON SMALL CELL LUNG CANCER