New combo therapy takes on hard-to-treat bile duct cancer

NCT ID NCT04238637

Ongoing Disease control Sponsor: Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest Source: ClinicalTrials.gov ↗

First seen Dec 10, 2025 · Last updated May 08, 2026 · Updated 16 times

Summary

This study tests whether adding immunotherapy drugs (durvalumab with or without tremelimumab) to a type of internal radiation therapy (Y-90 SIRT) can shrink tumors in people with advanced bile duct cancer that has not spread beyond the liver. About 50 adults whose cancer cannot be removed by surgery will receive the combination treatment. The goal is to see if the tumors respond and to monitor side effects.

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Contacts and locations

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Locations

Clinic Essen Center

Essen, Germany
Hannover Medical School

Hanover, Germany
Munich Clinic Bogenhausen

Munich, Germany
University Hospital Dresden

Dresden, Germany
University Hospital Essen

Essen, Germany
University Hospital Halle

Halle, Germany
University Hospital Jena

Jena, Germany
University Hospital Munich Grosshadern

Munich, Germany

Conditions

Explore the condition pages connected to this study.

INTRAHEPATIC CHOLANGIOCARCINOMA