Cure My Disease

Don't miss your cure!

 Log in / Sign up

Immunotherapy showdown: new drugs challenge standard chemo for advanced colon cancer

NCT ID NCT04008030

Ongoing Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

Summary

This large, late-stage trial is comparing two immunotherapy approaches against standard chemotherapy for people with advanced colorectal cancer that has spread and has specific genetic features (MSI-H/dMMR). The study aims to see if the immunotherapy drugs nivolumab alone or combined with ipilimumab can help patients live longer without their cancer getting worse compared to usual chemotherapy. It involved 839 participants who were randomly assigned to one of the three treatment groups.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for METASTATIC COLORECTAL CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Locations

  • Local Institution - 0001

    Milan, 20162, Italy

  • Local Institution - 0002

    Padua, 35128, Italy

  • Local Institution - 0003

    Genova, 16132, Italy

  • Local Institution - 0004

    Naples, 80131, Italy

  • Local Institution - 0005

    Madrid, 28041, Spain

  • Local Institution - 0006

    Barcelona, 08035, Spain

  • Local Institution - 0007

    Essen, 45122, Germany

  • Local Institution - 0008

    Hanover, 30625, Germany

  • Local Institution - 0009

    Heidelberg, 69120, Germany

  • Local Institution - 0010

    Munich, 81377, Germany

  • Local Institution - 0011

    Edmonton, Alberta, T6G 1Z2, Canada

  • Local Institution - 0013

    Toronto, Ontario, M5G 1X5, Canada

  • Local Institution - 0015

    Sherbrooke, Quebec, J1H 5N4, Canada

  • Local Institution - 0016

    Montreal, Quebec, H2X 3E4, Canada

  • Local Institution - 0017

    Heidelberg, Victoria, 3084, Australia

  • Local Institution - 0018

    Elizabeth Vale, South Australia, 5112, Australia

  • Local Institution - 0019

    Westmead, New South Wales, 2145, Australia

  • Local Institution - 0022

    Dublin, Ireland

  • Local Institution - 0024

    Leuven, 3000, Belgium

  • Local Institution - 0025

    Anderlecht, Bruxelles-Capitale, Région de, 1070, Belgium

  • Local Institution - 0026

    Limerick, V94 F858, Ireland

  • Local Institution - 0027

    Paris, 75012, France

  • Local Institution - 0028

    Besançon, 25030, France

  • Local Institution - 0029

    Lyon, 69373, France

  • Local Institution - 0030

    Montpellier, 34298, France

  • Local Institution - 0031

    Poitiers, 86000, France

  • Local Institution - 0032

    Nantes, 44093, France

  • Local Institution - 0033

    Bergen, 5021, Norway

  • Local Institution - 0034

    Lorenskog, 1478, Norway

  • Local Institution - 0035

    Oslo, 0450, Norway

  • Local Institution - 0036

    Vejle, 7100, Denmark

  • Local Institution - 0038

    Herlev, 2730, Denmark

  • Local Institution - 0039

    Vancouver, British Columbia, V5Z 4E6, Canada

  • Local Institution - 0040

    Toulouse, 31059, France

  • Local Institution - 0041

    Clayton, Victoria, 3168, Australia

  • Local Institution - 0042

    Dresden, 01307, Germany

  • Local Institution - 0043

    Hamburg, 20249, Germany

  • Local Institution - 0044

    Marburg, 35043, Germany

  • Local Institution - 0045

    Bonheiden, Antwerpen, 2820, Belgium

  • Local Institution - 0049

    Oxford, OX3 7LE, United Kingdom

  • Local Institution - 0050

    Utrecht, 3584 CX, Netherlands

  • Local Institution - 0051

    Amsterdam, North Holland, 1081 HV, Netherlands

  • Local Institution - 0052

    Amsterdam, North Holland, 1066 CX, Netherlands

  • Local Institution - 0053

    Woolloongabba, Queensland, 4102, Australia

  • Local Institution - 0054

    Roma, 00168, Italy

  • Local Institution - 0055

    Catania, 95122, Italy

  • Local Institution - 0056

    Badalona, Barcelona [Barcelona], 08916, Spain

  • Local Institution - 0058

    Rio Piedras, 00935, Puerto Rico

  • Local Institution - 0059

    Los Angeles, California, 90033, United States

  • Local Institution - 0060

    New York, New York, 10065, United States

  • Local Institution - 0061

    Pessac, 33604, France

  • Local Institution - 0063

    Seville, 41013, Spain

  • Local Institution - 0064

    Graz, 8036, Austria

  • Local Institution - 0065

    Vienna, 1090, Austria

  • Local Institution - 0066

    Marseille, 13005, France

  • Local Institution - 0067

    Wiener Neustadt, 2700, Austria

  • Local Institution - 0068

    Linz, 4010, Austria

  • Local Institution - 0069

    Santiago, Santiago Metropolitan, 8320000, Chile

  • Local Institution - 0070

    Independencia, Santiago Metropolitan, Chile

  • Local Institution - 0071

    Santiago, Santiago Metropolitan, 7500921, Chile

  • Local Institution - 0072

    CABA, 1426, Argentina

  • Local Institution - 0073

    Ciudad Autonoma Beunos Aires, Buenos Aires, 1431, Argentina

  • Local Institution - 0074

    Viedma, Río Negro Province, 8500, Argentina

  • Local Institution - 0076

    Cluj-Napoca, Cluj, 400015, Romania

  • Local Institution - 0080

    Bucharest, 022328, Romania

  • Local Institution - 0081

    Craiova, Dolj, 200542, Romania

  • Local Institution - 0084

    Buenos Aires, 1093, Argentina

  • Local Institution - 0085

    Hradec Králové, 500 05, Czechia

  • Local Institution - 0086

    Olomouc, 779 00, Czechia

  • Local Institution - 0087

    Brno, 656 53, Czechia

  • Local Institution - 0088

    Nový Jičín, 741 01, Czechia

  • Local Institution - 0089

    Suceava, 720237, Romania

  • Local Institution - 0091

    Dublin, Dublin, Ireland

  • Local Institution - 0092

    Adana, 01060, Turkey (Türkiye)

  • Local Institution - 0094

    São José do Rio Preto, São Paulo, 15090000, Brazil

  • Local Institution - 0095

    São Paulo, São Paulo, 01509-010, Brazil

  • Local Institution - 0096

    Ipatinga, Minas Gerais, 35160-158, Brazil

  • Local Institution - 0100

    CABA, 1199, Argentina

  • Local Institution - 0101

    Istanbul, 34300, Turkey (Türkiye)

  • Local Institution - 0102

    Barretos, São Paulo, 14780-070, Brazil

  • Local Institution - 0103

    Denver, Colorado, 80218, United States

  • Local Institution - 0104

    Roanoke, Virginia, 24014, United States

  • Local Institution - 0105

    Portland, Oregon, 97227, United States

  • Local Institution - 0106

    Dallas, Texas, 75246, United States

  • Local Institution - 0107

    Kashiwa-shi, Chiba, 2778577, Japan

  • Local Institution - 0108

    Sunto-gun, Shizuoka, 4118777, Japan

  • Local Institution - 0109

    Nagoya, Aichi-ken, 4648681, Japan

  • Local Institution - 0110

    Kitaadachigun, Saitama, 362-0806, Japan

  • Local Institution - 0111

    Kawasaki, Kanagawa, 216-8511, Japan

  • Local Institution - 0112

    Chiba, Chiba, 260-8717, Japan

  • Local Institution - 0113

    Koto-ku, Tokyo, 135-8550, Japan

  • Local Institution - 0114

    Osaka, 540-0006, Japan

  • Local Institution - 0115

    Suita-shi, Osaka, 565-0871, Japan

  • Local Institution - 0116

    Fukuoka, Fukuoka, 8111395, Japan

  • Local Institution - 0117

    Hamburg, 22763, Germany

  • Local Institution - 0118

    Chuo-ku, Tokyo, 1040045, Japan

  • Local Institution - 0119

    Arlington Heights, Illinois, 60005, United States

  • Local Institution - 0120

    Salzburg, 5020, Austria

  • Local Institution - 0121

    Pittsburgh, Pennsylvania, 15232, United States

  • Local Institution - 0123

    Athens, 11528, Greece

  • Local Institution - 0124

    Cholargós, 15562, Greece

  • Local Institution - 0125

    Heraklion, 71110, Greece

  • Local Institution - 0126

    Ioannina, 45500, Greece

  • Local Institution - 0127

    London, EC1A 7BE, United Kingdom

  • Local Institution - 0128

    Kanazawa, Ishikawa-ken, 9208641, Japan

  • Local Institution - 0129

    Minato-ku, Tokyo, 1058470, Japan

  • Local Institution - 0130

    Sacramento, California, 95817, United States

  • Local Institution - 0131

    Shanghai, Shanghai Municipality, 200120, China

  • Local Institution - 0132

    Matsuyama, Ehime, 791-0280, Japan

  • Local Institution - 0133

    Kumamoto, Kumamoto, 8608556, Japan

  • Local Institution - 0137

    Hangzhou, Zhejiang, 310009, China

  • Local Institution - 0138

    Lille, Nord, 59000, France

  • Local Institution - 0143

    Shanghai, Shanghai Municipality, 200080, China

  • Local Institution - 0145

    Changzhou, Jiangsu, 213003, China

  • Local Institution - 0146

    Hefei, Anhui, 230061, China

  • Local Institution - 0149

    Guangzhou, Guangdong, 510655, China

  • Local Institution - 0151

    Nanchang, Jiangxi, 330006, China

  • Local Institution - 0153

    Guangzhou, Guangdong, 510095, China

  • Local Institution - 0154

    Qingdao, Shandong, 266061, China

  • Local Institution - 0158

    Foshan, Guangdong, 528000, China

  • Local Institution - 0160

    Nanning, Guangxi, 530000, China

  • Local Institution - 0162

    Shenyang, Liaoning, 110042, China

  • Local Institution - 0163

    Xiamen, Fujian, 361003, China

  • Local Institution - 0164

    Changchun, Jilin, 130021, China

  • Local Institution - 0165

    Yantai, Shandong, 264000, China

  • Local Institution - 0167

    Guangzhou, Guangdong, 510080, China

  • Local Institution - 0168

    Brasov, 002200, Romania

  • Local Institution - 0171

    Valencia, 46014, Spain

  • Local Institution - 0172

    Málaga, 29010, Spain

  • Local Institution - 0173

    A Coruña, 15006, Spain

  • Local Institution - 0174

    Sapporo, Hokkaido, 0608648, Japan

  • Local Institution - 0175

    Yokohama, Kanagawa, 241-8515, Japan

  • Local Institution - 0176

    Limoges, Haute-Vienne, 87042, France

  • Local Institution - 0177

    Kurashiki, Okayama-ken, 7108602, Japan

  • Local Institution - 0180

    Harbin, Heilongjiang, 150040, China

  • Local Institution - 0181

    Zhengzhou, Henan, 450052, China

  • Local Institution - 0183

    Lyon, 69008, France

  • Local Institution - 0184

    Strasbourg, 67200, France

  • Local Institution - 0186

    Bayonne, 64109, France

  • Local Institution - 0187

    Hidaka, Saitama, 350-1298, Japan

  • Local Institution - 0188

    Xi'an, Shaanxi, 710126, China

  • Local Institution - 0189

    Ōsaki, Miyagi, 9896183, Japan

  • Local Institution - 0192

    Porto Alegre, Rio Grande do Sul, 91350-200, Brazil

  • Local Institution - 0193

    São Paulo, 01246-000, Brazil

  • Local Institution - 0195

    Kunming, Yunnan, 650106, China

  • Local Institution - 0196

    Nanning, Guangxi, 530021, China

  • Local Institution - 0197

    Changsha, Hunan, 410013, China

  • Local Institution - 0199

    Rio de Janeiro, 20231-050, Brazil

  • Local Institution - 0200

    Natal, Rio Grande do Norte, 59075-740, Brazil

  • Local Institution - 0205

    Iași, 700483, Romania

  • Local Institution - 0206

    Ningbo, Zhejiang, 315041, China

  • Local Institution - 0207

    Zhangzhou, Fujian, 363000, China

  • Local Institution - 0210

    Jinan, Shandong, 250117, China

  • Local Institution - 0211

    Lanzhou, Gansu, 730030, China

  • Local Institution - 0212

    Linyi, Shandong, 276001, China

  • Local Institution - 0221

    Shanghai, Shanghai Municipality, 200131, China

  • Local Institution - 0222

    Athens, 11525, Greece

Conditions

Explore the condition pages connected to this study.

METASTATIC COLORECTAL CANCER