New hope for rare kidney disease? trial tests imlifidase

NCT ID NCT05679401

Terminated Disease control Sponsor: Hansa Biopharma AB Source: ClinicalTrials.gov ↗

First seen Oct 01, 2025 · Last updated Jun 05, 2026 · Updated 33 times

Summary

This study tested a new drug called imlifidase for people with severe Goodpasture disease, a rare condition where the immune system attacks the kidneys and lungs. The trial compared imlifidase plus standard care to standard care alone in 50 adults with poor kidney function. The goal was to see if imlifidase could improve kidney function at 6 months. However, the study was terminated early.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

ASST degli Spedali Civili di Brescia - SC Nefrologia

Brescia, 25123, Italy
Aarhus University Hospital, Renal Medicine and Clinical Medicine

Aarhus N, Central Jutland, 8200, Denmark
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
CHU Bordeaux, Hôpital Pellegrin, Service nephrologie, transplantation, dialyse, aphereses

Bordeaux, New Aquitaine, 33076 cedex, France
CHU Grenoble Alpes - Michallon Hospital, Nephrology, Hemodialysis, Apheresis and Kidney Transplantation

Grenoble, Auvergne-Rhône-Alpes, 38043, France
CHU Lille. Nephrology, dialysis transplantation

Lille, Haus-de-France, 59037, France
CHU de Nantes, Hôtel-Dieu, Le service de néphrologie et immunologie clinique

Nantes, Pays de la Loire Region, 44000, France
CHU de Rouen, Department of Nephrology,Transplantation, and Hemodialysis

Bois-Guillaume, Normandy, 76130, France
Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Dept. of Vasculitis

Cambridge, Cambridgeshire, CB2 0QQ, United Kingdom
Carl-Gustav-Carus University Hospital, Medizinische Klinik III, Nephrologie

Dresden, Saxony, 01307, Germany
Charité Department of Nephrology and Intensive Care

Berlin, 10117, Germany
Department of Renal Medicine, Cork University Hospital

Cork, T12 DC4A, Ireland
Hammersmith Hospital, Renal medicine and centre for inflammatory diseases

London, W12 0HS, United Kingdom
Hospital Clinic de Barcelona

Barcelona, 08036, Spain
Hôpital Rangueil, CHU de Toulouse, Department of Nephrology and Organ transplantation

Toulouse, Occitanie, 31059, France
IRCCS Policlinico San Martino University Hospital, Department of Internal Medicine, Division of Nephrology

Genova, Genova-Liguria, 16132, Italy
IRCCS S. Orsola - Malpighi University Hospital - Nephrology, Dialysis and Transplantation Unit (pav 15)

Bologna, 40138, Italy
John Hopkins Medical Institution

Baltimore, Maryland, 21287, United States
Karolinska University Hospital

Huddinge, 14186, Sweden
LMU Klinikum, Medical Clinic IV / Department of Nephrology

Munich, Bavaria, 81377, Germany
Leiden University Medical Center, Department of Nephrology

Leiden, South Holland, 2333, Netherlands
Linköping University Hospital

Linköping, 58185, Sweden
Manchester University Hospitals NHS Foundation Trust

Manchester, M13 9WL, United Kingdom
Med Uni Graz / LKH-UNIV Klinikum Graz, Klinische Abteilung fuer Nephrologie

Graz, Stiermark, 8036, Austria
Medical University Innsbruck, Dept of Internal Medicine IV (Nephrology and Hypertension)

Innsbruck, Tyrol, 6020, Austria
Medical University of Vienna, Dept of Medicine III, Division of Nephrology and dialysis

Vienna, 1090, Austria
Nouvel Hôpital Civil (University Hospital of Strasbourg)

Strasbourg, Grand Est, 67091 Cedex, France
Odense University Hospital, Medical Nephrology, Department Y

Odense, Region Syddanmark, 5000, Denmark
Radboudumc

Nijmegen, 6525 GA, Netherlands
Rigshospitalet, Department of Nephrology

Copenhagen, 2100, Denmark
Royal Infirmary of Edinburgh, Department of Renal Medicine

Edinburgh, EH16 4SA, United Kingdom
Skåne University Hospital, Department of Nephrology

Lund, 22185, Sweden
Tenon Hospital, Renal intensive care unit

Paris, Île-de-France Region, 75020, France
The Ohio State University Wexner Medical Center

Columbus, Ohio, 43201, United States
UCLA Medical Center Plaza

Los Angeles, California, 90024, United States
UNC Kidney Center/Division of Nephrology & Hypertension

Chapel Hill, North Carolina, 27599-7155, United States
UZ Leuven

Leuven, 3000, Belgium
Uniklinik Koeln-Klinik II fuer Innere Medizin

Cologne, North Rhine-Westphalia, 50937, Germany
Uniklinik RWTH Aachen

Aachen, North Rhine-Westphalia, 52074, Germany
Universitaetsklinikum Erlangen - Medizinische Klinik 4

Erlangen, 91054, Germany
University College London, Royal Free Hospital, Department of Renal Medicine

London, NW3 2QG, United Kingdom
University Hospital Hamburg-Eppendorf, III Department of Medicine and Nephrology

Hamburg, 20246, Germany
University Hospital Vall d'Hebron

Barcelona, 08035, Spain
University Hospital of Marseille, Nephrology - Renal transplantation service

Marseille, Bouches-du-Rhône, 13385, France
University Medical Center Groningen, Division of Nephrology

Groningen, 9713GZ, Netherlands
University of Minnesota Health Clinical Research Unit

Minneapolis, Minnesota, 55455, United States
Uppsala University Hospital, Department of Medical Sciences, Renal Medicine

Uppsala, 751 85, Sweden
Všeobecná fakultní nemocnice v Praze

Prague, Prague, 12808, Czechia

Conditions

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ANTI-GLOMERULAR BASEMENT MEMBRANE ANTIBODY DISEASE ANTI-GLOMERULAR BASEMENT MEMBRANE ANTIBODY DISEASE ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE GOOD PASTURE SYNDROME GOODPASTURE SYNDROME