Experimental drug combo aims to tame bone marrow cancer

NCT ID NCT05371964

Recruiting now Disease control Sponsor: Geron Corporation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests two drugs—imetelstat and ruxolitinib—together in people with myelofibrosis, a type of bone marrow cancer. The study has two parts: first, finding a safe dose of the combination, and second, checking if it improves symptoms like fatigue and spleen discomfort. About 36 adults with intermediate or high-risk myelofibrosis are being recruited.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: imetelstat and ruxolitinib
What this could lead to: If it works, this combination could offer better symptom control and possibly slow disease progression for people with myelofibrosis.
What could go wrong: This is an early Phase 1 trial with only 36 participants, so safety and effectiveness are not yet proven. Side effects from the drug combination are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

myelofibrosis primary myelofibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYELOFIBROSIS

Contacts and locations

Locations

City of Hope
RECRUITING

Duarte, California, 91010, United States
City of Hope
RECRUITING

Irvine, California, 92618, United States
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
H. Lee Moffitt Cancer Center and Research Institute, Inc.
RECRUITING

Tampa, Florida, 33612, United States
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Texas Oncology
WITHDRAWN

Denison, Texas, 75020, United States
Texas Oncology
WITHDRAWN

Tyler, Texas, 75702, United States
University of Miami
RECRUITING

Coral Gables, Florida, 33146, United States

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