Major trial tests new drug to protect kidneys from silent disease

NCT ID NCT06291376

Recruiting now Disease control Sponsor: Alexion Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

Summary

This study is testing whether the drug ravulizumab can slow the progression of IgA nephropathy (IgAN), a kidney disease that can lead to kidney failure. About 510 adults with IgAN who are at high risk of their disease getting worse will receive either the study drug or a placebo through an IV infusion. The main goals are to see if the drug reduces protein in the urine and helps preserve long-term kidney function over about two years.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

Research Site
RECRUITING

Alabaster, Alabama, 35007, United States
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Phoenix, Arizona, 85054, United States
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Loma Linda, California, 92354, United States
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Los Angeles, California, 90022, United States
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Los Angeles, California, 90027, United States
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Los Angeles, California, 90095, United States
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Orange, California, 92868, United States
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San Diego, California, 92120, United States
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San Francisco, California, 94143, United States
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Stanford, California, 94305, United States
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Torrance, California, 90502, United States
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Valencia, California, 91355, United States
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Aurora, Colorado, 80045, United States
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Bay Pines, Florida, 33744, United States
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Miami, Florida, 33136, United States
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Orlando, Florida, 32806, United States
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Acworth, Georgia, 30101, United States
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Atlanta, Georgia, 30322, United States
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Lawrenceville, Georgia, 30046, United States
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Iowa City, Iowa, 52242, United States
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New Orleans, Louisiana, 70121, United States
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Shreveport, Louisiana, 71103, United States
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Augusta, Maine, 04330, United States
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Boston, Massachusetts, 02111, United States
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Boston, Massachusetts, 02114, United States
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Boston, Massachusetts, 02115, United States
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Worcester, Massachusetts, 01655, United States
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Minneapolis, Minnesota, 55435, United States
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Minneapolis, Minnesota, 55455, United States
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Kansas City, Missouri, 64111, United States
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North Las Vegas, Nevada, 89086, United States
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Albany, New York, 12208, United States
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East Setauket, New York, 11733, United States
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New York, New York, 10016, United States
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The Bronx, New York, 10468, United States
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Columbus, Ohio, 43210, United States
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Charleston, South Carolina, 29425, United States
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Knoxville, Tennessee, 37920, United States
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Arlington, Texas, 76002, United States
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Houston, Texas, 77030, United States
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Houston, Texas, 77054, United States
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San Antonio, Texas, 78229, United States
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Shenandoah, Texas, 77384, United States
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Temple, Texas, 76508, United States
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Charlottesville, Virginia, 22908, United States
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Milwaukee, Wisconsin, 53226, United States
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Ciudad de Buenos Aires, C1015ABO, Argentina
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Ciudad de Buenos Aires, C1425AGC, Argentina
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Córdoba, X5016KET, Argentina
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La Plata, B1902COS, Argentina
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Rosario, 2000, Argentina
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WITHDRAWN

San Juan Bautista, 1888, Argentina
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WITHDRAWN

Camperdown, 2050, Australia
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Canberra, 2605, Australia
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Clayton, 3168, Australia
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Concord, 2139, Australia
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Herston, 4029, Australia
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Liverpool, 2170, Australia
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Parkville, 3050, Australia
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Perth, 6000, Australia
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Southport, 4222, Australia
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St Albans, 3021, Australia
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Graz, 8036, Austria
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Innsbruck, 6020, Austria
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Linz, 4020, Austria
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Brussels, 1090, Belgium
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TERMINATED

Edegem, 2650, Belgium
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Leuven, 3000, Belgium
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Belo Horizonte, 30110-934, Brazil
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Belo Horizonte, 30150-221, Brazil
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Botucatu, 18618-687, Brazil
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Curitiba, 80440-020, Brazil
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Fortaleza, 60430-270, Brazil
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Recife, 50670-901, Brazil
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Ribeirão Preto, 14051-140, Brazil
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São José do Rio Preto, 15090-000, Brazil
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São Paulo, 04038-002, Brazil
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São Paulo, 05403-000, Brazil
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Winnipeg, Manitoba, R2V 3M3, Canada
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Brampton, Ontario, L6T 5T6, Canada
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London, Ontario, N6A 5W9, Canada
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Toronto, Ontario, M5G 2C4, Canada
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Araucania, 4781151, Chile
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Providencia, 7500000, Chile
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Santiago, 7500922, Chile
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Santiago, 8330034, Chile
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Valdivia, 5090146, Chile
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Baotou, 14010, China
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Beijing, 100029, China
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Beijing, 100034, China
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Beijing, 100044, China
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Changsha, 410013, China
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Changzhou, 272100, China
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Chengdu, 610000, China
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Chengdu, 610072, China
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Chongqing, 400010, China
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Guangzhou, 510100, China
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Hangzhou, 310003, China
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Jinan, 250021, China
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Jinhua, 321000, China
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Lanzhou, 730000, China
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Luoyang, 471000, China
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Nanchang, 330006, China
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Nanchang, 330008, China
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Nanjing, 210009, China
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Nanjing, 210011, China
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Nanjing, 210029, China
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Ningbo, 315010, China
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Qingdao, 110016, China
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Shanghai, 200025, China
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Shanghai, 200040, China
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Shanghai, 200065, China
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Shenzhen, 518036, China
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Shenzhen, 518053, China
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Ürümqi, 831118, China
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Wuhan, 430060, China
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Wuxi, 214023, China
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Xi'an, 710061, China
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Yantai, 264000, China
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Yibin, 610500, China
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Yinchuan, 750004, China
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Zhengzhou, 450052, China
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WITHDRAWN

Zhongshan, 528401, China
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Nový Jičín, 741 01, Czechia
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Prague, 128 00, Czechia
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Prague, 140 00, Czechia
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Amiens, 80054, France
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Bayonne, 64100, France
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Brest, 29200, France
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Chambéry, 73011, France
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Le Kremlin-Bicêtre, 94270, France
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Marseille, 13385, France
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Nantes, 44093, France
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Paris, 75010, France
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Paris, 75015, France
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Saint-Priest-en-Jarez, 42270, France
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Strasbourg, 67091, France
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Toulouse, 31059, France
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Aachen, 52074, Germany
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Berlin, 10117, Germany
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Cologne, 50937, Germany
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Erlangen, 91054, Germany
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Essen, 45122, Germany
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Greifswald, 17475, Germany
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Hanover, 30625, Germany
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Konstanz, 78464, Germany
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Mainz, 55131, Germany
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München, 81377, Germany
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München, 81657, Germany
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Villingen-Schwenningen, 78052, Germany
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Athens, 11527, Greece
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Athens, 12462, Greece
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Heraklion, 71500, Greece
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Pátrai, 26504, Greece
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Thessaloniki, 57010, Greece
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Hong Kong, 999077, Hong Kong
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Hong Kong, Hong Kong
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Haifa, 3109601, Israel
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Jerusalem, 91120, Israel
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Nazareth, 16100, Israel
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Petah Tikva, 49372, Israel
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Tel Aviv, 6423906, Israel
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Agrigento, 92100, Italy
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Bologna, 40138, Italy
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Brescia, 25123, Italy
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Cagliari, 09121, Italy
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Florence, 50134, Italy
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Milan, 20122, Italy
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Milan, 20132, Italy
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Padua, 35128, Italy
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Parma, 43126, Italy
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Torino, 10154, Italy
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Torrette, 60126, Italy
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Verona, 37126, Italy
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Bunkyō City, 113-8431, Japan
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Chiba, 260-8677, Japan
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Chiba, 260-8712, Japan
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Fukuoka, 815-8555, Japan
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Kamakura, 247-8533, Japan
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Kasugai-shi, 486-8510, Japan
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Kitakyushu-shi, 802-8555, Japan
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Kobe, 650-0047, Japan
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Matsumoto-shi, 390-8621, Japan
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Matsuyama, 790-8524, Japan
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Nagoya, 466-8650, Japan
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Osaka, 534-0021, Japan
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Osaka, 545-8586, Japan
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Sapporo, 060-8604, Japan
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Urayasu-shi, 279-0021, Japan
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Ipoh, 30990, Malaysia
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Johor Bahru, 80100, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Seremban, 70300, Malaysia
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WITHDRAWN

Taiping, 34000, Malaysia
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Amsterdam, 1105 AZ, Netherlands
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Rotterdam, 3045 PM, Netherlands
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Bialystok, 15-276, Poland
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Bialystok, 15-540, Poland
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Krakow, 31-513, Poland
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Lodz, 92-213, Poland
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Lublin, 20-090, Poland
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Olsztyn, 10-561, Poland
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Poznan, 60-355, Poland
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Szczecin, 70-111, Poland
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Warsaw, 02-006, Poland
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Warsaw, 02-507, Poland
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Dammam, 31444, Saudi Arabia
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Jeddah, 21499, Saudi Arabia
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Riyadh, 11211, Saudi Arabia
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Riyadh, 12231, Saudi Arabia
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Banská Bystrica, 974 01, Slovakia
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Martin, 03659, Slovakia
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Anyang-si, 14068, South Korea
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Busan, 49241, South Korea
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Deagu, 41944, South Korea
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Gwangju, 61469, South Korea
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Gyeonggi-do, 13620, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05278, South Korea
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Suwon, 16499, South Korea
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A Coruña, 15006, Spain
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Alcalá de Henares, 28805, Spain
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COMPLETED

Lleida, 25198, Spain
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Madrid, 28031, Spain
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COMPLETED

Madrid, 28040, Spain
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WITHDRAWN

Madrid, 28046, Spain
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Málaga, 29010, Spain
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Murcia, 30120, Spain
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Oviedo, 33011, Spain
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Seville, 41013, Spain
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Tarragona, 09-43005, Spain
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Zaragoza, 50009, Spain
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Kaohsiung City, 80756, Taiwan
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Kaohsiung City, 81362, Taiwan
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Kaohsiung City, 833401, Taiwan
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New Taipei City, 220, Taiwan
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New Taipei City, 23561, Taiwan
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Taichung, 40705, Taiwan
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Taichung, Taiwan
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Tainan, 70403, Taiwan
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Taipei, 10002, Taiwan
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Taoyuan District, 333, Taiwan
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Bangkok, 10330, Thailand
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Bangkok, 10400, Thailand
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Bangkok, 10700, Thailand
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Chiang Mai, 50200, Thailand
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Khon Kaen, 40002, Thailand
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Ankara, 06560, Turkey (Türkiye)
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Bursa, 16059, Turkey (Türkiye)
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Istanbul, 34098, Turkey (Türkiye)
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Istanbul, 34452, Turkey (Türkiye)
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WITHDRAWN

Kahramanmaraş, 46100, Turkey (Türkiye)
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ACTIVE_NOT_RECRUITING

Kayseri, 38039, Turkey (Türkiye)
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Kocaeli, 41380, Turkey (Türkiye)
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Konya, 42080, Turkey (Türkiye)
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WITHDRAWN

Pamukkale, 20070, Turkey (Türkiye)
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Cambridge, CB2 0QQ, United Kingdom
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Doncaster, DN2 5LT, United Kingdom
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WITHDRAWN

Dundee, DD1 9SY, United Kingdom
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ACTIVE_NOT_RECRUITING

Leicester, Le5 4PW, United Kingdom
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ACTIVE_NOT_RECRUITING

London, E1 1BB, United Kingdom
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WITHDRAWN

London, SE1 9RT, United Kingdom
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ACTIVE_NOT_RECRUITING

Manchester, M13 9WL, United Kingdom
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Reading, RG1 5AN, United Kingdom
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WITHDRAWN

Salford, M6 8HD, United Kingdom
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Stevenage, SG1 4AB, United Kingdom

Conditions

Explore the condition pages connected to this study.

IGAN IMMUNOGLOBULIN A NEPHROPATHY