New drug shows promise in slowing kidney disease progression

NCT ID NCT04578834

Completed Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This large, completed Phase 3 trial tested whether the drug iptacopan (LNP023) could help control IgA nephropathy, a serious kidney disease. It involved 518 adults with the condition who were already on standard care. The main goals were to see if the drug could reduce harmful protein in the urine and slow the long-term decline of kidney function over two years.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Locations

AKDHC Medical Research ServicesLLC

Phoenix, Arizona, 85016, United States
AZ Kidney Dise and Hypertension Ctr

Glendale, Arizona, 85306, United States
Boise Kidney and Hypertension

Boise, Idaho, 83706, United States
Brigham and Womens Hosp Harvard Med School

Boston, Massachusetts, 02115, United States
CaRe Research

Chubbuck, Idaho, 83202, United States
Clin Rsrch Consult a JCCT Company

Kansas City, Missouri, 64111, United States
Columbia University Irving Medical

New York, New York, 10032, United States
DaVita Clinical Research

Las Vegas, Nevada, 89146, United States
Dallas Renal Group

Dallas, Texas, 75230, United States
Johns Hopkins Hospital

Baltimore, Maryland, 21287, United States
Kaiser Permanente

San Diego, California, 92111, United States
Mayo Clinic Rochester

Rochester, Minnesota, 55905, United States
Nep Assoc of Northern Illinois

Hinsdale, Illinois, 60521, United States
Nephrology Associates PA

Newark, Delaware, 19713, United States
New Jersey Kidney Care

Jersey City, New Jersey, 07305, United States
North America Research Institute

San Dimas, California, 91773, United States
Novartis Investigative Site

Córdoba, Córdoba Province, X5016JDA, Argentina
Novartis Investigative Site

Córdoba, Córdoba Province, X5016KEH, Argentina
Novartis Investigative Site

CABA, C1181ACH, Argentina
Novartis Investigative Site

CABA, C1426ABP, Argentina
Novartis Investigative Site

Santa Fe, S3000EPV, Argentina
Novartis Investigative Site

Westmead, New South Wales, 2145, Australia
Novartis Investigative Site

Woolloongabba, Queensland, 4102, Australia
Novartis Investigative Site

Adelaide, South Australia, 5000, Australia
Novartis Investigative Site

Parkville, Victoria, 3065, Australia
Novartis Investigative Site

St Albans, Victoria, 3021, Australia
Novartis Investigative Site

Roeselare, West-Vlaanderen, 8800, Belgium
Novartis Investigative Site

Edegem, 2650, Belgium
Novartis Investigative Site

Leuven, 3000, Belgium
Novartis Investigative Site

Belo Horizonte, Minas Gerais, 30150-221, Brazil
Novartis Investigative Site

Curitiba, Paraná, 80440-020, Brazil
Novartis Investigative Site

Porto Alegre, Rio Grande do Sul, 90035-074, Brazil
Novartis Investigative Site

São Paulo, São Paulo, 04038-002, Brazil
Novartis Investigative Site

São Paulo, São Paulo, 05403 000, Brazil
Novartis Investigative Site

Sao Jose Rio Preto, 15090 000, Brazil
Novartis Investigative Site

Oshawa, Ontario, L1G 2B9, Canada
Novartis Investigative Site

Temuco, 4781151, Chile
Novartis Investigative Site

Beijing, Beijing Municipality, 100013, China
Novartis Investigative Site

Beijing, Beijing Municipality, 102218, China
Novartis Investigative Site

Guangzhou, Guangdong, 510030, China
Novartis Investigative Site

Guangzhou, Guangdong, 510630, China
Novartis Investigative Site

Shenzhen, Guangdong, 518000, China
Novartis Investigative Site

Luoyang, Henan, 471003, China
Novartis Investigative Site

Zhengzhou, Henan, 450003, China
Novartis Investigative Site

Changsha, Hunan, 410011, China
Novartis Investigative Site

Changchun, Jilin, 130041, China
Novartis Investigative Site

Yinchuan, Ningxia, 750004, China
Novartis Investigative Site

Taiyuan, Shanxi, 030001, China
Novartis Investigative Site

Xian, Shanxi, 710061, China
Novartis Investigative Site

Ürümqi, Xinjiang, 830001, China
Novartis Investigative Site

Hangzhou, Zhejiang, 310003, China
Novartis Investigative Site

Ningbo, Zhejiang, 315016, China
Novartis Investigative Site

Wenzhou, Zhejiang, 325000, China
Novartis Investigative Site

Beijing, 100029, China
Novartis Investigative Site

Beijing, 100034, China
Novartis Investigative Site

Guangzhou, 510080, China
Novartis Investigative Site

Ningbo, 315010, China
Novartis Investigative Site

Qingdao, 266000, China
Novartis Investigative Site

Shanghai, 200025, China
Novartis Investigative Site

Shanghai, 200040, China
Novartis Investigative Site

Shenzhen, 518036, China
Novartis Investigative Site

Medellín, Antioquia, 050001, Colombia
Novartis Investigative Site

Barranquilla, Atlántico, 080020, Colombia
Novartis Investigative Site

Prague, 128 08, Czechia
Novartis Investigative Site

Aalborg, 9000, Denmark
Novartis Investigative Site

Arhus N, DK-8200, Denmark
Novartis Investigative Site

Copenhagen, DK-2100, Denmark
Novartis Investigative Site

Odense C, 5000, Denmark
Novartis Investigative Site

Marseille, 13005, France
Novartis Investigative Site

Montpellier, 34295, France
Novartis Investigative Site

Paris, 75015, France
Novartis Investigative Site

Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
Novartis Investigative Site

Stuttgart, Baden-Wurttemberg, 70376, Germany
Novartis Investigative Site

Göttingen, Lower Saxony, 37075, Germany
Novartis Investigative Site

Dresden, Saxony, 01307, Germany
Novartis Investigative Site

Aachen, 52074, Germany
Novartis Investigative Site

Berlin, 13353, Germany
Novartis Investigative Site

Essen, 45147, Germany
Novartis Investigative Site

Hanover, 30625, Germany
Novartis Investigative Site

Kiel, 24105, Germany
Novartis Investigative Site

Magdeburg, 39120, Germany
Novartis Investigative Site

Mainz, 55131, Germany
Novartis Investigative Site

Tübingen, 72076, Germany
Novartis Investigative Site

Ulm, 89081, Germany
Novartis Investigative Site

Pécs, Baranya, 7623, Hungary
Novartis Investigative Site

Debrecen, Hajdu Bihar Megye, 4032, Hungary
Novartis Investigative Site

Szeged, 6725, Hungary
Novartis Investigative Site

Bangalore, Karnataka, 560004, India
Novartis Investigative Site

New Delhi, National Capital Territory of Delhi, 110017, India
Novartis Investigative Site

New Delhi, National Capital Territory of Delhi, 110029, India
Novartis Investigative Site

Hyderabad, Telangana, 500082, India
Novartis Investigative Site

Ashkelon, 7830604, Israel
Novartis Investigative Site

Jerusalem, 9112001, Israel
Novartis Investigative Site

Petah Tikva, 4941492, Israel
Novartis Investigative Site

Bologna, BO, 40138, Italy
Novartis Investigative Site

Naples, 80131, Italy
Novartis Investigative Site

Kasugai, Aichi-ken, 486-8510, Japan
Novartis Investigative Site

Toyoake, Aichi-ken, 470 1192, Japan
Novartis Investigative Site

Toyota, Aichi-ken, 471-8513, Japan
Novartis Investigative Site

Sapporo, Hokkaido, 060-8604, Japan
Novartis Investigative Site

Sapporo, Hokkaido, 68555, Japan
Novartis Investigative Site

Kawasaki, Kanagawa, 213-8587, Japan
Novartis Investigative Site

Yokohama, Kanagawa, 224-8503, Japan
Novartis Investigative Site

Yokohama, Kanagawa-ku, 236-0004, Japan
Novartis Investigative Site

Kyoto, Kyoto, 605-0981, Japan
Novartis Investigative Site

Matsumoto, Nagano, 3908621, Japan
Novartis Investigative Site

Osaka, Osaka, 5340021, Japan
Novartis Investigative Site

Ōmihachiman, Shiga, 523-0082, Japan
Novartis Investigative Site

Chiba, 2608712, Japan
Novartis Investigative Site

Niigata, 9518520, Japan
Novartis Investigative Site

Okayama, 7008558, Japan
Novartis Investigative Site

Osaka, 5300012, Japan
Novartis Investigative Site

Kuala Lumpur, Kuala Lumpur, 50586, Malaysia
Novartis Investigative Site

Kuala Lumpur, 59100, Malaysia
Novartis Investigative Site

Mexicali, Baja California Norte, 21200, Mexico
Novartis Investigative Site

Mexico City, 03100, Mexico
Novartis Investigative Site

Querétaro, 76000, Mexico
Novartis Investigative Site

Groningen, Provincie Groningen, 9713 GZ, Netherlands
Novartis Investigative Site

Nordbyhagen, Oslo County, 1478, Norway
Novartis Investigative Site

Bergen, NO-5021, Norway
Novartis Investigative Site

Omsk, 644112, Russia
Novartis Investigative Site

Rostov-on-Don, 344022, Russia
Novartis Investigative Site

Saint Petersburg, 197110, Russia
Novartis Investigative Site

Singapore, 119074, Singapore
Novartis Investigative Site

Singapore, 169608, Singapore
Novartis Investigative Site

Košice, Slovakia, 040 11, Slovakia
Novartis Investigative Site

Maribor, Slovenia, 2000, Slovenia
Novartis Investigative Site

Ljubljana, 1000, Slovenia
Novartis Investigative Site

Bloemfontein, Free State, 9301, South Africa
Novartis Investigative Site

Bundang Gu, Gyeonggi-do, 13620, South Korea
Novartis Investigative Site

Seoul, Korea, 02841, South Korea
Novartis Investigative Site

Seoul, Korea, 03080, South Korea
Novartis Investigative Site

Seoul, Korea, 03312, South Korea
Novartis Investigative Site

Cheongju-si, North Chungcheong, 28644, South Korea
Novartis Investigative Site

Busan, 47392, South Korea
Novartis Investigative Site

Seoul, 03722, South Korea
Novartis Investigative Site

Seoul, 06591, South Korea
Novartis Investigative Site

Seoul, 06973, South Korea
Novartis Investigative Site

Seoul, 134 727, South Korea
Novartis Investigative Site

Taegu, 41944, South Korea
Novartis Investigative Site

Pamplona, Navarre, 31008, Spain
Novartis Investigative Site

Barcelona, 08036, Spain
Novartis Investigative Site

Salamanca, 37007, Spain
Novartis Investigative Site

Seville, 41013, Spain
Novartis Investigative Site

Danderyd, 182 88, Sweden
Novartis Investigative Site

Stockholm, 141 86, Sweden
Novartis Investigative Site

Kaohsiung City, 83301, Taiwan
Novartis Investigative Site

New Taipei City, 22060, Taiwan
Novartis Investigative Site

New Taipei City, 23561, Taiwan
Novartis Investigative Site

Taichung, 40447, Taiwan
Novartis Investigative Site

Taipei, 10002, Taiwan
Novartis Investigative Site

Taoyuan District, 33305, Taiwan
Novartis Investigative Site

Bangkok, 10330, Thailand
Novartis Investigative Site

Bangkok, 10400, Thailand
Novartis Investigative Site

Bangkok, 10700, Thailand
Novartis Investigative Site

Istanbul, Fatih, 34093, Turkey (Türkiye)
Novartis Investigative Site

Istanbul, Fatih, 34098, Turkey (Türkiye)
Novartis Investigative Site

Köseköy, Kocaeli, 41380, Turkey (Türkiye)
Novartis Investigative Site

Antalya, Konyaalti, 07070, Turkey (Türkiye)
Novartis Investigative Site

Kayseri, Melikgazi, 38039, Turkey (Türkiye)
Novartis Investigative Site

Istanbul, Sariyer, 34396, Turkey (Türkiye)
Novartis Investigative Site

Istanbul, Sultangazi, 34265, Turkey (Türkiye)
Novartis Investigative Site

Ankara, Yenimahalle, 06500, Turkey (Türkiye)
Novartis Investigative Site

Mersin, Yenisehir, 33110, Turkey (Türkiye)
Novartis Investigative Site

Newcastle upon Tyne, Tyne and Wear, NE7 7DN, United Kingdom
Novartis Investigative Site

Leicester, LE5 4PW, United Kingdom
Novartis Investigative Site

London, SE5 9RS, United Kingdom
Novartis Investigative Site

London, SW17 0QT, United Kingdom
Novartis Investigative Site

Salford, M6 8HD, United Kingdom
Novartis Investigative Site

Ho Chi Minh City, VNM, 700000, Vietnam
Novartis Investigative Site

Ho Chi Minh City, 700000, Vietnam
Prolato Clinical Research Center

Houston, Texas, 77054, United States
Renal Associates of Baton Rouge

Baton Rouge, Louisiana, 80808, United States
UCLA Medical Center

Los Angeles, California, 90095, United States
Univ of Washington Medi Cen

Seattle, Washington, 98104, United States
University of Colorado Anschutz

Aurora, Colorado, 80045, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States

Conditions

Explore the condition pages connected to this study.

IGA NEPHROPATHY