Experimental combo therapy targets Hard-to-Treat skin cancer
NCT ID NCT06940440
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early study tests a new cancer vaccine called IFx-Hu2.0 given together with the immunotherapy drug pembrolizumab (Keytruda) in 9 adults with advanced or metastatic Merkel cell carcinoma. The vaccine is injected directly into a tumor, and pembrolizumab is given through an IV. The main goals are to see if the combination is safe and if it is possible to inject the vaccine into internal tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
IFx-Hu2.0 (a cancer vaccine injected into a tumor) and pembrolizumab (an immunotherapy drug given by IV)
What this could lead to
If it works, this could point toward a new combination treatment for advanced Merkel cell carcinoma that is hard to treat.
What could go wrong
This is a very early Phase 1 trial with only 9 people, so it is mainly checking safety and whether the injection is possible. It is too small and early to know if it will help patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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H. Lee Moffitt Cancer Center and Research Institute
RECRUITINGTampa, Florida, 33612, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Wisconsin Carbone Cancer Center
RECRUITINGMadison, Wisconsin, 53792, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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