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Toe walking study reveals best treatment and genetic links

NCT ID NCT06305689

Knowledge-focused Sponsor: Shriners Hospitals for Children Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at two treatments for children who walk on their toes (idiopathic toe walking): casting (non-surgical) and surgery. Researchers measured walking patterns, muscle function, and daily function in 65 children aged 6-18. They also searched for genes that might be linked to the condition. The goal was to find which treatment works best and understand the genetic causes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

65 people

The number who actually took part.

Started

Jan 2022

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 to 18 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Diagnosis of Idiopathic Toe Walking Persistent (ITWp) 2. Between the ages of 6-18 years 3. Passive dorsiflexion dorsiflexion with knee extension between -10 plantar flexion - + 5 degrees of dorsiflexion, DiGiovanni defined an isolated gastrocnemius contracture as maximum passive ankle dorsiflexion as \< 5 degrees with the knee in full extension Exclusion Criteria: 1. Diagnosis of Autism or autism spectrum disorder 2. Presence of any indicators of trauma, neuromuscular influence or neurogenic influence as identified by using the Toe Walking Tool

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Idiopathic toe walking

Contacts and locations

Locations

  • Shriners Children's Spokane

    Spokane, Washington, 99204, United States

  • Shriners Hospitals for Children

    Sacramento, California, 95817, United States

  • Shriners Hospitals for Children

    Chicago, Illinois, 60707, United States

  • Shriners Hospitals for Children

    Lexington, Kentucky, 40508, United States

  • Shriners Hospitals for Children

    Portland, Oregon, 97239, United States

  • Shriners Hospitals for Children

    Philadelphia, Pennsylvania, 19140, United States

  • Shriners Hospitals for Children

    Greenville, South Carolina, 29605, United States

  • Shriners Hospitals for Children

    Salt Lake City, Utah, 84103, United States

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