New drug combo shows promise for Tough-to-Treat lymphoma

NCT ID NCT01955499

First seen Nov 01, 2025 · Last updated Apr 24, 2026 · Updated 20 times

Summary

This early-stage study tests the safety and best dose of two drugs—ibrutinib and lenalidomide—given together to people with B-cell non-Hodgkin lymphoma that has come back or stopped responding to treatment. The goal is to find a dose that controls the cancer with manageable side effects. About 39 adults with certain lymphoma subtypes will take part.

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Contacts and locations

Locations

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

  • University Health Network-Princess Margaret Hospital

    Toronto, Ontario, M5G 2M9, Canada

  • University of Chicago Comprehensive Cancer Center

    Chicago, Illinois, 60637, United States

Conditions

Explore the condition pages connected to this study.