Experimental drug shows promise for Tough-to-Treat melanoma

NCT ID NCT02581930

First seen Nov 01, 2025 · Last updated Apr 24, 2026 · Updated 21 times

Summary

This study tested a drug called ibrutinib in 18 people with stage IV melanoma that had not responded to previous treatments. The goal was to see if the drug could shrink tumors or slow the cancer's growth. Ibrutinib works by blocking certain enzymes that cancer cells need to grow.

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Contacts and locations

Locations

  • Case Western Reserve University

    Cleveland, Ohio, 44106, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Los Angeles General Medical Center

    Los Angeles, California, 90033, United States

  • Moffitt Cancer Center

    Tampa, Florida, 33612, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

  • UCHealth University of Colorado Hospital

    Aurora, Colorado, 80045, United States

  • UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina, 27599, United States

  • USC / Norris Comprehensive Cancer Center

    Los Angeles, California, 90033, United States

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California, 95817, United States

  • University of Kentucky/Markey Cancer Center

    Lexington, Kentucky, 40536, United States

  • University of Virginia Cancer Center

    Charlottesville, Virginia, 22908, United States

  • University of Wisconsin Carbone Cancer Center - University Hospital

    Madison, Wisconsin, 53792, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.