Metformin may stop severe pregnancy sickness before it starts

NCT ID NCT07129473

First seen Jan 07, 2026 · Last updated May 20, 2026 · Updated 20 times

Summary

This study tests whether taking metformin-XR daily before getting pregnant can lower the risk and severity of Hyperemesis Gravidarum (HG)—extreme nausea and vomiting during pregnancy—in women aged 18-49 who had HG before and are trying to conceive. Participants will either take the drug or join a survey-only group. Researchers will track side effects, pregnancy outcomes, and which women respond best.

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