Could a malaria drug help kids with a rare kidney disease?

NCT ID NCT04937907

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tested whether hydroxychloroquine, a drug used for malaria and autoimmune conditions, can safely reduce blood and protein in the urine of children with X-linked Alport syndrome, a genetic kidney disease. Fifty children aged 3 to 18 with stable kidney function took the drug for 48 weeks. The goal was to see if it could help control kidney damage, not cure the disease.

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Conditions

The condition(s) this trial relates to.

Alport syndrome hereditary nephritis X-linked Alport syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Shanghai Children's Hospital

    Shanghai, Shanghai Municipality, 200062, China