Light-Activated gel shows promise for rare skin cancer
NCT ID NCT06470451
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 3 trial tests a gel called HyBryte, which is activated by visible light, for treating cutaneous T-cell lymphoma (CTCL), a rare type of skin cancer. About 80 adults with early-stage CTCL will apply the gel or a placebo twice a week for 18 weeks, then receive light treatment. The goal is to see if the gel can significantly reduce the size and severity of skin lesions.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
HyBryte (hypericin sodium) gel plus visible light activation
What this could lead to
If successful, this could provide a new topical treatment option for early-stage cutaneous T-cell lymphoma, potentially reducing skin lesions without systemic side effects.
What could go wrong
This is a relatively small Phase 3 trial (80 participants), and the treatment may not work better than placebo. Skin sensitivity and local reactions are possible risks.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CUTANEOUS T CELL LYMPHOMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Accellacare (PMG)
COMPLETEDWilmington, North Carolina, 28411, United States
-
Austin Institute for Clinical Research
RECRUITINGPflugerville, Texas, 78660, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Columbia University Medical Center
COMPLETEDNew York, New York, 10032, United States
-
Dawes Fretzin Dermatology Group
RECRUITINGIndianapolis, Indiana, 46256, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Hospital of the University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Inova Schar Cancer Institute
RECRUITINGFairfax, Virginia, 22031, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
MD Anderson
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
Contact
-
Mayo Clinic
RECRUITINGScottsdale, Arizona, 85259, United States
Contact
Contact Phone: •••-•••-••••
-
Medical Dermatology Specialists
COMPLETEDPhoenix, Arizona, 85006, United States
-
Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
Contact Email: •••••@•••••
-
Penn State Health Hershey Medical Center
RECRUITINGHershey, Pennsylvania, 17033, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Rochester Skin Lymphoma Medical Group
RECRUITINGFairport, New York, 14450, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Therapeutics Clinical Research
COMPLETEDSan Diego, California, 92123, United States
-
University of Pittsburgh Medical Center
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
University of South Florida
RECRUITINGTampa, Florida, 33612, United States
-
Vanderbilt University
COMPLETEDNashville, Tennessee, 37212, United States
-
Washington University
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••