New drug combo aims to stop Post-Surgery nausea in its tracks
NCT ID NCT07709897
First seen Jul 17, 2026 · Last updated Jul 17, 2026
Summary
This study tests an experimental drug called HRS5580, given together with a standard anti-nausea medication (palonosetron), to prevent nausea and vomiting after surgery. About 260 adults undergoing planned surgeries lasting at least 2 hours will receive one of three doses of HRS5580 or a placebo, alongside palonosetron. The main goal is to see if the combination helps patients avoid vomiting or needing rescue medication for up to 72 hours after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- an experimental drug called HRS5580 combined with palonosetron hydrochloride
- What this could lead to
- If successful, this could provide a more effective option for preventing nausea and vomiting after surgery, reducing patient discomfort and complications.
- What could go wrong
- This is an early phase 2 trial with a small number of participants, so results may not confirm effectiveness or safety. The best dose is still being explored.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Fudan University Zhongshan Hospital
Shanghai, Shanghai Municipality, 200032, China
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Tianjin Nankai Hospital
Tianjin, Tianjin Municipality, 300100, China