New hope for tough pancreatic cancer: targeted drug combo enters final testing phase
NCT ID NCT07232875
First seen Jun 27, 2026 · Last updated Jul 16, 2026 · Updated 2 times
Summary
This Phase 3 trial is testing whether adding the experimental drug HRS-4642 to standard chemotherapy can help people with advanced pancreatic cancer that has a specific genetic change (KRAS G12D). About 588 participants will be randomly assigned to receive either the drug combo or a placebo plus chemo. The study aims to see if the combination improves survival or delays cancer progression compared to chemo alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- HRS-4642 (a targeted drug) plus chemotherapy (AG regimen)
- What this could lead to
- If successful, this could provide a new first-line treatment option for people with advanced pancreatic cancer that has a specific KRAS G12D mutation, potentially improving how long they live or delaying cancer growth.
- What could go wrong
- This is an early-stage Phase 3 trial that hasn't started recruiting yet. The drug may not work better than chemotherapy alone, and side effects from combining treatments could be significant. Results may not apply to all pancreatic cancer patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Renji Hospital, Shanghai Jiao Tong University School of Medicine
RECRUITINGShanghai, Shanghai Municipality, 200127, China
Contact