New combo therapy aims to supercharge immune system against HPV cancer
NCT ID NCT04260126
Summary
This study tested whether adding a new immunotherapy called PDS0101 to an existing drug (pembrolizumab) could better treat advanced head and neck cancer caused by HPV16. It involved 95 adults whose cancer had returned or spread. The goal was to see if the combination could help the patients' own immune systems fight the cancer more effectively.
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Contacts and locations
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Locations
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Atlantic Health
Morristown, New Jersey, 07962, United States
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Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
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Cleveland Clinic Florida
Weston, Florida, 33331, United States
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Edinburgh Cancer Centre
Edinburgh, UK EH4 2XU, United Kingdom
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FDI Clinical Research
San Juan, Puerto Rico, 00927, Puerto Rico
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Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111, United States
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Marin Cancer Center
Greenbrae, California, 94904, United States
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Mayo Clinic
Jacksonville, Florida, 32224, United States
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Mayo Clinic
Rochester, Minnesota, 55902, United States
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Medical University of South Carolina Hollings Cancer Center
Charleston, South Carolina, 29425, United States
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Ohio State University
Columbus, Ohio, 43210, United States
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St. James Hospital
Dublin, D08NHY1, Ireland
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Texas Oncology - Sammons Cancer Center
Dallas, Texas, 75246, United States
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The Royal Marsden NHS Foundation Trust (Chelsea)
Chelsea, London, SW3 6JJ, United Kingdom
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The Royal Marsden NHS Foundation Trust (Sutton)
Sutton, Surrey, SM2 5PT, United Kingdom
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The University of Virginia
Charlottesville, Virginia, 22908, United States
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University of California San Francisco
San Francisco, California, 94158, United States
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University of Kentucky Chandler Medical Center - Markey Cancer Center
Lexington, Kentucky, 40536, United States
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University of Maryland Greenebaum Comprehensive Cancer Center
Baltimore, Maryland, 21201, United States
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University of Michigan
Ann Arbor, Michigan, 48109, United States
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University of North Carolina
Chapel Hill, North Carolina, 27599, United States
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University of Tennessee
Knoxville, Tennessee, 37920, United States
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West Virginia University
Morgantown, West Virginia, 26506, United States
Conditions
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