BioNTech tests new cancer combo in major head & neck trial

NCT ID NCT04534205

Recruiting now Disease control Sponsor: BioNTech SE Source: ClinicalTrials.gov ↗

Summary

This trial is testing whether adding a new drug called BNT113 to a standard immunotherapy (pembrolizumab) works better than the standard treatment alone for people with advanced head and neck cancer linked to HPV16. It aims to see if the combination helps patients live longer and keeps the cancer from growing. The study will enroll about 350 adults whose cancer cannot be removed by surgery and who have not had prior treatment for their advanced disease.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

A.O.U. Maggiore della Carita
WITHDRAWN

Novara, 28100, Italy
ASST Spedali Civili Brescia
RECRUITING

Brescia, 25123, Italy
Aberdeen Royal Infirmary
RECRUITING

Aberdeen, AB25 2ZN, United Kingdom
Addenbrooke's Hospital - Cambridge University Hospitals
RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Ajou University Hospital
RECRUITING

Suwon, 16499, South Korea
Ankara Bilkent Sehir Hastanesi
WITHDRAWN

Ankara, 06800, Turkey (Türkiye)
Azienda Ospedaliera Universitaria Senese Policlinico Le Scotte
RECRUITING

Siena, 53100, Italy
Azienda Sanitaria Universitaria Integrata Friuli Centrale - Presidio ospedaliero di Udine
WITHDRAWN

Udine, 33100, Italy
Bankstown-Lidcombe Hospital
WITHDRAWN

Bankstown, 2200, Australia
Baskent University
WITHDRAWN

Yüreğir, 01250, Turkey (Türkiye)
Beatson West of Scotland Cancer Centre
RECRUITING

Glasgow, G12 0YN, United Kingdom
Belfast Health and Social Care Trust, Belfast City Hospital
RECRUITING

Belfast, BT9 7AB, United Kingdom
British Columbia Cancer Agency
RECRUITING

Kelowna, V1Y 5L3, Canada
CAIPO Centro para la Atencion Integral del Paciente Oncologico
RECRUITING

San Miguel de Tucumán, 4000, Argentina
CHR de la Citadelle
RECRUITING

Liège, 4000, Belgium
CHU de BORDEAUX, Hopital Saint Andre
RECRUITING

Bordeaux, 33075, France
CHU de Caen Normandie
RECRUITING

Caen, 14033, France
CHU de Tours Hopital Bretonneau
RECRUITING

Tours, 37044, France
California Research Institute
WITHDRAWN

Los Angeles, California, 90027, United States
Cancer Research SA
RECRUITING

Adelaide, 5000, Australia
Caritas Klinikum Saarbrucken St. Theresia
RECRUITING

Saarbrücken, 66113, Germany
Central Hospital of Northern Pest - Military Hospital
RECRUITING

Budapest, 1062, Hungary
Centre Georges Francois Leclerc
ACTIVE_NOT_RECRUITING

Dijon, 21079, France
Centro Clinico Academico
WITHDRAWN

Braga, 4710-243, Portugal
Centro Estatal de Cancerologia de Chihuahua
RECRUITING

Chihuahua City, 31000, Mexico
Centro Hospitalar Universitario Lisboa Norte
RECRUITING

Lisbon, 1649-028, Portugal
Centro Hospitalar de Vila Nova de Gaia/Espinho
WITHDRAWN

Gaia, 4434-502, Portugal
Centro Oncologico Riojano Integral
RECRUITING

La Rioja, 5300, Argentina
Centro de Atencion e Investigacion Clinica en Oncologia (CAICO)
RECRUITING

Yucatán, 97134, Mexico
Centro de Estudios Clinicos SAGA
RECRUITING

Santiago, 7500653, Chile
Centro de Estudios y Prevención del Cáncer (CEPREC)
RECRUITING

Tuxtla Gutiérrez, Region Chiapas, 29038, Mexico
Centro de Investigacion Pergamino SA - Clinica Pergamino
RECRUITING

Pergamino, 2700, Argentina
Centro de Oncología e Investigación Buenos Aires COIBA
RECRUITING

Berazategui, B1884BBF, Argentina
Centrum Medyczne Pratia Poznań
WITHDRAWN

Poznan, 60-185, Poland
Chang Bing Show Chwan Memorial Hospital
RECRUITING

Changhua, 50544, Taiwan
Chang Gung Memorial Hospital-Kaohsiung Branch
RECRUITING

Kaohsiung City, 833401, Taiwan
Changhua Christian Hospital
RECRUITING

Changhua, 50006, Taiwan
Charite Universitätsklinikum Berlin - Campus Benjamin Franklin
RECRUITING

Berlin, 13353, Germany
Chonnam National University Hwasun Hospital
RECRUITING

Hwasun, 58128, South Korea
Chungnam National University Hospital
WITHDRAWN

Daejeon, 35015, South Korea
Clinica Universidad de Navarra - Madrid (CUN-M)
RECRUITING

Madrid, 28027, Spain
Clinica Universidad de Navarra - Pamplona (CUN-P)
RECRUITING

Pamplona, 31008, Spain
Clinica Viedma
WITHDRAWN

Viedma, 8500, Argentina
Clinique Victor Hugo
WITHDRAWN

Le Mans, 72000, France
Coffs Harbour Hospital
WITHDRAWN

Coffs Harbour, 2450, Australia
Complejo Hospitalario de Jaen
RECRUITING

Jaén, 23007, Spain
Consultorio del Dr. Joaquín Gabriel Reinoso Toledo
RECRUITING

Monterrey, 64320, Mexico
Cross Cancer Institute
RECRUITING

Edmonton, T6G 1Z2, Canada
Cryptex Investigacion SA de CV
RECRUITING

Mexico City, 06100, Mexico
DEKK Onkologiai Klinika
WITHDRAWN

Debrecen, 4032, Hungary
Ege Universitesi Tip Fakultesi Hastanesi - Tulay Aktas Onkoloji Hastanesi
WITHDRAWN

Izmir, 35040, Turkey (Türkiye)
Fakultni Nemocnice Olomouc
RECRUITING

Olomouc, 779 00, Czechia
Flinders Medical Centre
RECRUITING

Bedford Park, 5042, Australia
Fundacao Universidade de Caxias do Sul - Instituto de Pesquisas em Saude IPS-UCS
RECRUITING

Caxias do Sul, 95070-560, Brazil
Fundación Arturo López Pérez
RECRUITING

Santiago, 7500921, Chile
Fundação PIO XII - Hospital de Amor Barretos
RECRUITING

Barretos, 14784-400, Brazil
Guy's Cancer Centre, Guy's Hospital
RECRUITING

London, SE1 9RT, United Kingdom
HNO, Kopf-und Halschirurgie Ordensklinikum Linz Barmherzigen Schwestern
RECRUITING

Linz, 4010, Austria
Hacettepe University Cancer Institute
ACTIVE_NOT_RECRUITING

Ankara, 06230, Turkey (Türkiye)
Hadassah Medical Center - Sharett Institute of Oncology
RECRUITING

Jerusalem, 49100, Israel
Hopital Prive du Confluent
WITHDRAWN

Nantes, 44277, France
Hopital de la Timone
RECRUITING

Marseille, 13005, France
Hospital Britanico de Buenos Aires
WITHDRAWN

Ciudad de Buenos Aires, 1280, Argentina
Hospital Civil de Guadalajara Fray Antonio Alcalde
RECRUITING

Guadalajara, 44280, Mexico
Hospital Clinic Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital Erasto Gaertner
RECRUITING

Curitiba, 81520-060, Brazil
Hospital Gustave Roussy
RECRUITING

Villejuif, 94800, France
Hospital La Fe
RECRUITING

Valencia, 46026, Spain
Hospital Mae de Deus
RECRUITING

Porto Alegre, 90110-270, Brazil
Hospital Marcio Cunha
RECRUITING

Ipatinga, 35162-189, Brazil
Hospital Miguel Servet
WITHDRAWN

Zaragoza, 50009, Spain
Hospital Na Bulovce (Nemocnice na Bulovce)
RECRUITING

Prague 8 - Liben, 180 00, Czechia
Hospital Regional de Malaga
RECRUITING

Málaga, 29010, Spain
Hospital Sao Lucas da PUCRS
RECRUITING

Porto Alegre, 90610-000, Brazil
Hospital Sao Rafael
RECRUITING

Salvador, 41253-190, Brazil
Hospital Univ. Dr. Josep Trueta
RECRUITING

Girona, 17007, Spain
Hospital Universitario "Dr Jose Eleuterio Gonzalez" Centro Universitario contra el Cáncer
RECRUITING

Monterrey, 64460, Mexico
Hospital Universitario Fundacion Jimenez Diaz
RECRUITING

Madrid, 28040, Spain
Hospital Universitario La Paz
WITHDRAWN

Madrid, 28046, Spain
Hospital Universitario Puerta de Hierro Majadahonda
RECRUITING

Majadahonda, 28222, Spain
Hospital Universitario Son Espases
RECRUITING

Palma de Mallorca, 07120, Spain
Hospital de Base de Sao Jose do Rio Preto
RECRUITING

São José do Rio Preto, 15090-000, Brazil
IBCC - Instituto Brasileiro de Controle do Cancer
RECRUITING

Vila Mariana, 04014-002, Brazil
IPO Lisboa Francisco Gentil
RECRUITING

Lisbon, 1099-023, Portugal
IRCCS Istituto Europeo di Oncologia
RECRUITING

Milan, 20141, Italy
IRCCS Ospedale San Raffaele
RECRUITING

Milan, 20132, Italy
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Inonu Universitesi - Turgut Ozal Tip Merkezi
WITHDRAWN

Malatya, 44280, Turkey (Türkiye)
Institut Curie
RECRUITING

Paris, 75005, France
Institut Curie, Groupe Hospitalier Paris Saint-Joseph (GHPSJ)
ACTIVE_NOT_RECRUITING

Paris, 75014, France
Institut de Radiothérapie Hartmann, GCS CCConcorde
WITHDRAWN

Levallois-Perret, 92300, France
Instituto Nacional de Cancer Jose de Alencar Gomes da Silva - INCA
RECRUITING

Rio de Janeiro, 20231-050, Brazil
Instituto Portugues de Oncologia do Porto Francisco Gentil, E.P.E
RECRUITING

Porto, 4200-072, Portugal
Instituto Português de Oncologia de Coimbra Francisco Gentil, E.P.E.
RECRUITING

Coimbra, 3000-075, Portugal
Instituto de Oncologia de Cordoba
RECRUITING

Córdoba, X500AA1, Argentina
Instituto de Oncologia de Rosario
RECRUITING

Rosario, 2000, Argentina
Instituto do Cancer do Estado de São Paulo
RECRUITING

São Paulo, 01246-000, Brazil
Irmandade Santa Casa de Misericordia de Porto Alegre Hospital Santa Rita
RECRUITING

Porto Alegre, 90050-170, Brazil
Istanbul Medeniyet University Medical Faculty
WITHDRAWN

Istanbul, 34722, Turkey (Türkiye)
Istanbul Universitesi Onkoloji Enstitusu
WITHDRAWN

Istanbul, 34093, Turkey (Türkiye)
Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty
WITHDRAWN

Istanbul, 34098, Turkey (Türkiye)
James Lind Centro de Investigación del Cáncer
WITHDRAWN

Temuco, 4800827, Chile
Jewish General Hospital
RECRUITING

Montreal, H3T 1E2, Canada
John Flynn Private Hospital
RECRUITING

Tugun, 4224, Australia
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, 80708, Taiwan
Kath. Marien Krankenhaus gGmbH
WITHDRAWN

Hamburg, 40878, Germany
Klinik für HNO-Heilkunde, Kopf- und Hals-Chirurgie
RECRUITING

Cologne, 50937, Germany
Klinikum rechts der Isar der TUM
RECRUITING

München, 81675, Germany
Konyang University Hospital
RECRUITING

Daejeon, 35365, South Korea
Korea University Anam Hospital
RECRUITING

Seoul, 02841, South Korea
Krankenhaus Nordwest GmbH
WITHDRAWN

Frankfurt am Main, 60488, Germany
LKH - Univ. Klinikum Graz
RECRUITING

Graz, 8036, Austria
Landeskrankenhaus/ Univ.-Kliniken Innsbruck
RECRUITING

Innsbruck, 6020, Austria
Leeds Teaching Hospitals NHS Trust (St James's University Hospital)
RECRUITING

Leeds, LS9 7TF, United Kingdom
MCM Pratia Krakow
WITHDRAWN

Krakow, 30-510, Poland
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mater Salutis Hospital AULSS 9 della Regione Veneto
RECRUITING

Legnago, 37045, Italy
McGill University Health Centre
RECRUITING

Montreal, H4A 3J1, Canada
Medical Park - Izmir Hastanesi
WITHDRAWN

Izmir, 35575, Turkey (Türkiye)
Medical Park Seyhan Hospital
WITHDRAWN

Adana, 01140, Turkey (Türkiye)
Medipol Mega Universite Hastanesi
WITHDRAWN

Istanbul, 34214, Turkey (Türkiye)
Medizinische Hochschule Hannover (MHH)
RECRUITING

Hanover, 30625, Germany
Medizinische Universitaetsklinik Tuebingen
RECRUITING

Tübingen, 72076, Germany
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10467, United States
Mount Vernon Cancer Centre, East and North Hertfordshire NHS Trust
RECRUITING

Stevenage, SG1 4AB, United Kingdom
MultiCare Regional Cancer Center
WITHDRAWN

Tacoma, Washington, 98405, United States
Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie
RECRUITING

Gliwice, 44-102, Poland
National Taiwan University Hospital
RECRUITING

Taipei, 100225, Taiwan
Norrlands University Hospital
WITHDRAWN

Umeå, 901 87, Sweden
Norton Cancer Institute
RECRUITING

Louisville, Kentucky, 40241, United States
Nottingham University Hospitals NHS Trust
RECRUITING

Nottingham, NG5 1PB, United Kingdom
Oaxaca Site Management Organization S. C.
RECRUITING

Oaxaca City, 68000, Mexico
Oncosite - Centro de Pesquisa Clinica em Oncologia
RECRUITING

Ijuí, 98700-000, Brazil
Ospedale del Mare
WITHDRAWN

Naples, 80147, Italy
Oxford Cancer Centre
RECRUITING

Oxford, OX3 7LE, United Kingdom
Princess Margaret Cancer Centre
WITHDRAWN

Toronto, M5G 2C1, Canada
Providence Cancer Institute
WITHDRAWN

Portland, Oregon, 97213, United States
Przychodnia Lekarska KOMED Roman Karaszewski
RECRUITING

Konin, 62-500, Poland
Rabin Medical Center
RECRUITING

Petah Tikva, 4941492, Israel
Rambam Health Clinical
RECRUITING

Haifa, 3109601, Israel
Royal North Shore Hospital
RECRUITING

Saint Leonards, 2065, Australia
Royal Preston Hospital Lancashire Teaching Hospitals NHS Foundation Trust
RECRUITING

Preston, PR2 9HT, United Kingdom
SRH Wald-Klinikum Gera GmbH
WITHDRAWN

Hamburg, 07548, Germany
Sahlgrenska University Hospital
WITHDRAWN

Gothenburg, 413 45, Sweden
Sanatorio Britanico
RECRUITING

Rosario, 2000, Argentina
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Skane University Hospital
WITHDRAWN

Lund, 221 85, Sweden
Sociedad de Metabolismo y Corazón S.C.
RECRUITING

Veracruz, 91900, Mexico
Southern Medical Day Care Centre
RECRUITING

Wollongong, 2500, Australia
St Vincent's Hospital
RECRUITING

Fitzroy, VIC 3065, Australia
Stanford Cancer Institute
COMPLETED

Palo Alto, California, 94304, United States
Szpitale Pomorskie Sp.zo.o
WITHDRAWN

Gdynia, 81-519, Poland
Taichung Veterans General Hospital
RECRUITING

Taichung, 407219, Taiwan
Taipei Veterans General Hospital
RECRUITING

Taipei, 11217, Taiwan
Tel Aviv Sourasky Medical Center
RECRUITING

Tel Aviv, 6423906, Israel
The Catholic University of Korea St. Vincent's Hospital
RECRUITING

Suwon, 16247, South Korea
The Catholic University of Korea, Seoul ST. Mary's Hospital
RECRUITING

Seoul, 06591, South Korea
The Christie NHS Foundation Trust
RECRUITING

Manchester, M20 4BX, United Kingdom
The Clatterbridge Cancer Centre
RECRUITING

Liverpool, L7 8YA, United Kingdom
The George Washington Cancer Center
RECRUITING

Washington D.C., District of Columbia, 20052, United States
The Royal Marsden Hospital - Sutton
RECRUITING

Sutton, SM2 5PT, United Kingdom
The Royal Marsden Hospital NHS Foundation Trust - Fulham Road
RECRUITING

London, SW3 6JJ, United Kingdom
The University of New Mexico Comprehensive Cancer Center
RECRUITING

Albuquerque, New Mexico, 87131, United States
Torbay Hospital - South Devon Healthcare NHS Foundation Trust
RECRUITING

Torquay, TQ2 7AA, United Kingdom
Trakya University
WITHDRAWN

Edirne, 22030, Turkey (Türkiye)
Tufts Medical Center
RECRUITING

Boston, Massachusetts, 02111, United States
UCLA Cancer Care
RECRUITING

Los Angeles, California, 90095, United States
UNIVERSITAETSMEDIZIN der Johannes Gutenberg-Universitaet Mainz
RECRUITING

Mainz, 55131, Germany
Uniklinikum Salzburg, Univ. Klinik fur Innere Medizin III
RECRUITING

Salzburg, 5020, Austria
Univeritätsklinikum Münster
RECRUITING

Münster, 48149, Germany
Universitaetsklinik Heidelberg
RECRUITING

Heidelberg, 69124, Germany
Universitaetsklinikum Wuerzburg
RECRUITING

Würzburg, 97080, Germany
Universitaetsmedizin Rostock - Medizinische Klink III (Hamatologie, Onkologie, Palliativmedizin)
RECRUITING

Rostock, 18057, Germany
Universitair Ziekenhuis Brussel
RECRUITING

Brussels, 1090, Belgium
Universitair Ziekenhuis Gent UZ Gent
RECRUITING

Ghent, 9000, Belgium
University Cancer and Blood Center
WITHDRAWN

Athens, Georgia, 30607, United States
University College London Hospitals
RECRUITING

London, NW 12 PG, United Kingdom
University Hospital Southampton NHS Foundation Trust
RECRUITING

Southampton, SO16 6YD, United Kingdom
University Hospitals Birmingham, Queen Elizabeth Hospital
RECRUITING

Birmingham, B15 2TH, United Kingdom
University of Cincinnati Cancer Center
RECRUITING

Cincinnati, Ohio, 45219, United States
University of Miami Miller School of Medicine
RECRUITING

Miami, Florida, 33136, United States
Universitätsklinikum Leipzig
RECRUITING

Leipzig, 04103, Germany
Uniwersyteckie Centrum Kliniczne
RECRUITING

Gdansk, 80-214, Poland
Uzsoki Utcai Korhaz Onkologiai Osztaly
WITHDRAWN

Budapest, 1145, Hungary
Velindre Cancer Centre
RECRUITING

Cardiff, CF14 2TL, United Kingdom
Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
Wojskowy Szpital Kliniczny z Poliklinika SP ZOZ
RECRUITING

Wroclaw, 50-981, Poland
Yale University
RECRUITING

New Haven, Connecticut, 06511, United States
Zala Megyei S. Rafael Korhaz
RECRUITING

Zalaegerszeg, 8900, Hungary

Conditions

Explore the condition pages connected to this study.

METASTATIC HEAD AND NECK CANCER RECURRENT HEAD AND NECK CANCER UNRESECTABLE HEAD AND NECK SQUAMOUS CELL CARCINOMA