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Can brain scans reveal how we avoid mixing up similar memories?

NCT ID NCT05092100

Knowledge-focused Sponsor: University of Oregon Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 31, 2026 · Last updated Sep 01, 2026 · Updated 1 time

Summary

Researchers at the University of Oregon are studying how healthy adults form distinct memories for similar experiences. Participants aged 18 to 80 will study and try to remember images while researchers vary how similar the images are and how they are presented. The team will use behavioral tests, fMRI scans, and eye tracking to measure memory accuracy and brain activity. The goal is to understand the neural mechanisms that help the brain reduce interference between similar memories.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Behavioral learning protocol with varied visual stimulus similarity, fMRI scanning, and eye tracking
What this could lead to
If it works, this could reveal how the brain avoids confusing similar memories, which may inform strategies to improve memory in aging or memory disorders.
What could go wrong
This is an observational study, not a treatment trial. It measures brain activity and behavior, so it cannot directly change or improve memory. Results may not apply to people with memory problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 2,900 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2021

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Participants in behavioral studies must be: * healthy and between the ages of 18-35 years old * native English speakers * right-handed. Participants in fMRI studies must be: * healthy and between the ages of 18-80 years old * native English speakers * right-handed. Exclusion Criteria: For behavioral studies: \- Potential participants will be informed that use of psychoactive drugs, mental health disorders, and chronic or temporary sleep deficits (an average of less than 6 hours of sleep over the past month or less than 4 hours of sleep the night prior to the experimental session) are reasons for exclusion because of the potential influence on cognitive functioning. For fMRI studies: * For some sub-studies, individuals older than age 35 will be excluded because of potential differences in cognitive and brain function across age groups that are beyond the scope of the proposed studies. * Individuals will be informed that use of psychoactive drugs, mental health disorders, and chronic or temporary sleep deficits (an average of less than 6 hours of sleep over the past month or less than 4 hours of sleep the night prior to the experimental session) are reasons for exclusion because of the potential influence on cognitive functioning.

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Conditions

The condition(s) this trial relates to.

Behavior

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Behavior

How to take part

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  1. The places running it

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  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

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Contacts and locations

Locations

  • University of Oregon

    Eugene, Oregon, 97403, United States

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